The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease. / Winther-Sørensen, Marie; Holst, Jens J; Wewer Albrechtsen, Nicolai J.

I: Current Opinion in Lipidology, Bind 34, Nr. 1, 2023, s. 27-31.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Winther-Sørensen, M, Holst, JJ & Wewer Albrechtsen, NJ 2023, 'The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease', Current Opinion in Lipidology, bind 34, nr. 1, s. 27-31. https://doi.org/10.1097/MOL.0000000000000857

APA

Winther-Sørensen, M., Holst, J. J., & Wewer Albrechtsen, N. J. (2023). The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease. Current Opinion in Lipidology, 34(1), 27-31. https://doi.org/10.1097/MOL.0000000000000857

Vancouver

Winther-Sørensen M, Holst JJ, Wewer Albrechtsen NJ. The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease. Current Opinion in Lipidology. 2023;34(1):27-31. https://doi.org/10.1097/MOL.0000000000000857

Author

Winther-Sørensen, Marie ; Holst, Jens J ; Wewer Albrechtsen, Nicolai J. / The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease. I: Current Opinion in Lipidology. 2023 ; Bind 34, Nr. 1. s. 27-31.

Bibtex

@article{938b323731e14f7e84af74089e103d46,

title = "The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease",

abstract = "PURPOSE OF REVIEW: Glucagon increases hepatic glucose production and in patients with metabolic diseases, glucagon secretion is increased contributing to diabetic hyperglycemia. This review explores the role of amino acids and lipids in the regulation of glucagon secretion and how it may be disturbed in metabolic diseases such as obesity and metabolic associated fatty liver disease (MAFLD).RECENT FINDINGS: Human and animal studies have shown that MAFLD is associated with glucagon resistance towards amino acid catabolism, resulting in elevated plasma levels of amino acids. A recent clinical study showed that MAFLD is also associated with glucagon resistance towards lipid metabolism. In contrast, MAFLD may not decrease hepatic sensitivity to the stimulatory effects of glucagon on glucose production.SUMMARY: Elevated plasma levels of amino acids and lipids associated with MAFLD may cause diabetogenic hyperglucagonemia. MAFLD and glucagon resistance may therefore be causally linked to hyperglycemia and the development of type 2 diabetes.",

author = "Marie Winther-S{\o}rensen and Holst, {Jens J} and {Wewer Albrechtsen}, {Nicolai J}",

year = "2023",

doi = "10.1097/MOL.0000000000000857",

language = "English",

volume = "34",

pages = "27--31",

journal = "Current Opinion in Lipidology",

issn = "0957-9672",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease

AU - Winther-Sørensen, Marie

AU - Holst, Jens J

AU - Wewer Albrechtsen, Nicolai J

PY - 2023

Y1 - 2023

N2 - PURPOSE OF REVIEW: Glucagon increases hepatic glucose production and in patients with metabolic diseases, glucagon secretion is increased contributing to diabetic hyperglycemia. This review explores the role of amino acids and lipids in the regulation of glucagon secretion and how it may be disturbed in metabolic diseases such as obesity and metabolic associated fatty liver disease (MAFLD).RECENT FINDINGS: Human and animal studies have shown that MAFLD is associated with glucagon resistance towards amino acid catabolism, resulting in elevated plasma levels of amino acids. A recent clinical study showed that MAFLD is also associated with glucagon resistance towards lipid metabolism. In contrast, MAFLD may not decrease hepatic sensitivity to the stimulatory effects of glucagon on glucose production.SUMMARY: Elevated plasma levels of amino acids and lipids associated with MAFLD may cause diabetogenic hyperglucagonemia. MAFLD and glucagon resistance may therefore be causally linked to hyperglycemia and the development of type 2 diabetes.

AB - PURPOSE OF REVIEW: Glucagon increases hepatic glucose production and in patients with metabolic diseases, glucagon secretion is increased contributing to diabetic hyperglycemia. This review explores the role of amino acids and lipids in the regulation of glucagon secretion and how it may be disturbed in metabolic diseases such as obesity and metabolic associated fatty liver disease (MAFLD).RECENT FINDINGS: Human and animal studies have shown that MAFLD is associated with glucagon resistance towards amino acid catabolism, resulting in elevated plasma levels of amino acids. A recent clinical study showed that MAFLD is also associated with glucagon resistance towards lipid metabolism. In contrast, MAFLD may not decrease hepatic sensitivity to the stimulatory effects of glucagon on glucose production.SUMMARY: Elevated plasma levels of amino acids and lipids associated with MAFLD may cause diabetogenic hyperglucagonemia. MAFLD and glucagon resistance may therefore be causally linked to hyperglycemia and the development of type 2 diabetes.

U2 - 10.1097/MOL.0000000000000857

DO - 10.1097/MOL.0000000000000857

M3 - Review

C2 - 36373738

VL - 34

SP - 27

EP - 31

JO - Current Opinion in Lipidology

JF - Current Opinion in Lipidology

SN - 0957-9672

IS - 1

ER -

ID: 331585469

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