The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation
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The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation. / Ziegler, A.K.; Jensen, S.M.; Schjerling, P.; Mackey, A.L.; Andersen, J.L.; Kjaer, M.
I: Experimental Gerontology, Bind 121, 2019, s. 19-32 .Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation
AU - Ziegler, A.K.
AU - Jensen, S.M.
AU - Schjerling, P.
AU - Mackey, A.L.
AU - Andersen, J.L.
AU - Kjaer, M.
PY - 2019
Y1 - 2019
N2 - Aim Chronic inflammation increases with age and is correlated positively to visceral fat mass, but inversely to muscle mass. We investigated the hypothesis that resistance training would increase muscle mass and strength together with a concomitant drop in local and systemic inflammation level independent of any changes in visceral fat tissue in elderly. Methods 25 subjects (mean 67, range 62–70 years) were randomized to 1 year of heavy resistance training (HRT) or control (CON), and tested at 0, 4 and 12 months for physical performance, body composition (DXA), vastus lateralis muscle area (MRI) local and systemic inflammation (blood and muscle). In addition, systemic and local muscle immunological responses to acute exercise was determined before and after the training period. Results Increases in muscle mass (≈2%, p 0.05). Blood C-Reactive Protein declined over time in both groups (p
AB - Aim Chronic inflammation increases with age and is correlated positively to visceral fat mass, but inversely to muscle mass. We investigated the hypothesis that resistance training would increase muscle mass and strength together with a concomitant drop in local and systemic inflammation level independent of any changes in visceral fat tissue in elderly. Methods 25 subjects (mean 67, range 62–70 years) were randomized to 1 year of heavy resistance training (HRT) or control (CON), and tested at 0, 4 and 12 months for physical performance, body composition (DXA), vastus lateralis muscle area (MRI) local and systemic inflammation (blood and muscle). In addition, systemic and local muscle immunological responses to acute exercise was determined before and after the training period. Results Increases in muscle mass (≈2%, p 0.05). Blood C-Reactive Protein declined over time in both groups (p
KW - Strength training
KW - Skeletal muscle
KW - Chronic inflammation
KW - Elderly
KW - Visceral fat
KW - Physical training
U2 - 10.1016/j.exger.2019.03.007
DO - 10.1016/j.exger.2019.03.007
M3 - Journal article
C2 - 30905721
VL - 121
SP - 19
EP - 32
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -
ID: 215324701