The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue

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Standard

The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. / Larsen, Steen; Danielsen, J H; Søndergård, Stine Dam; Søgaard, D; Vigelsoe, A; Dybboe, R; Skaaby, S; Dela, F; Helge, J W.

I: Scandinavian Journal of Medicine & Science in Sports, Bind 25, Nr. 1, 02.2015, s. e59-e69.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Larsen, S, Danielsen, JH, Søndergård, SD, Søgaard, D, Vigelsoe, A, Dybboe, R, Skaaby, S, Dela, F & Helge, JW 2015, 'The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue', Scandinavian Journal of Medicine & Science in Sports, bind 25, nr. 1, s. e59-e69. https://doi.org/10.1111/sms.12252

APA

Larsen, S., Danielsen, J. H., Søndergård, S. D., Søgaard, D., Vigelsoe, A., Dybboe, R., Skaaby, S., Dela, F., & Helge, J. W. (2015). The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scandinavian Journal of Medicine & Science in Sports, 25(1), e59-e69. https://doi.org/10.1111/sms.12252

Vancouver

Larsen S, Danielsen JH, Søndergård SD, Søgaard D, Vigelsoe A, Dybboe R o.a. The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scandinavian Journal of Medicine & Science in Sports. 2015 feb.;25(1):e59-e69. https://doi.org/10.1111/sms.12252

Author

Larsen, Steen ; Danielsen, J H ; Søndergård, Stine Dam ; Søgaard, D ; Vigelsoe, A ; Dybboe, R ; Skaaby, S ; Dela, F ; Helge, J W. / The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. I: Scandinavian Journal of Medicine & Science in Sports. 2015 ; Bind 25, Nr. 1. s. e59-e69.

Bibtex

@article{542504aac7684868b6c4e0980305c18e,
title = "The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue",
abstract = "High-intensity interval training (HIT) is known to increase mitochondrial content in a similar way as endurance training [60-90% of maximal oxygen uptake (VO2peak )]. Whether HIT increases the mitochondria's ability to oxidize lipids is currently debated. We investigated the effect of HIT on mitochondrial fat oxidation in skeletal muscle and adipose tissue. Mitochondrial oxidative phosphorylation (OXPHOS) capacity, mitochondrial substrate sensitivity (Km (app) ), and mitochondrial content were measured in skeletal muscle and adipose tissue in healthy overweight subjects before and after 6 weeks of HIT (three times per week at 298 ± 21 W). HIT significantly increased VO2peak from 2.9 ± 0.2 to 3.1 ± 0.2 L/min. No differences were seen in maximal fat oxidation in either skeletal muscle or adipose tissue. Km (app) for octanoyl carnitine or palmitoyl carnitine were similar after training in skeletal muscle and adipose tissue. Maximal OXPHOS capacity with complex I- and II-linked substrates was increased after training in skeletal muscle but not in adipose tissue. In conclusion, 6 weeks of HIT increased VO2peak . Mitochondrial content and mitochondrial OXPHOS capacity were increased in skeletal muscle, but not in adipose tissue. Furthermore, mitochondrial fat oxidation was not improved in either skeletal muscle or adipose tissue.",
author = "Steen Larsen and Danielsen, {J H} and S{\o}nderg{\aa}rd, {Stine Dam} and D S{\o}gaard and A Vigelsoe and R Dybboe and S Skaaby and F Dela and Helge, {J W}",
note = "{\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2015",
month = feb,
doi = "10.1111/sms.12252",
language = "English",
volume = "25",
pages = "e59--e69",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue

AU - Larsen, Steen

AU - Danielsen, J H

AU - Søndergård, Stine Dam

AU - Søgaard, D

AU - Vigelsoe, A

AU - Dybboe, R

AU - Skaaby, S

AU - Dela, F

AU - Helge, J W

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2015/2

Y1 - 2015/2

N2 - High-intensity interval training (HIT) is known to increase mitochondrial content in a similar way as endurance training [60-90% of maximal oxygen uptake (VO2peak )]. Whether HIT increases the mitochondria's ability to oxidize lipids is currently debated. We investigated the effect of HIT on mitochondrial fat oxidation in skeletal muscle and adipose tissue. Mitochondrial oxidative phosphorylation (OXPHOS) capacity, mitochondrial substrate sensitivity (Km (app) ), and mitochondrial content were measured in skeletal muscle and adipose tissue in healthy overweight subjects before and after 6 weeks of HIT (three times per week at 298 ± 21 W). HIT significantly increased VO2peak from 2.9 ± 0.2 to 3.1 ± 0.2 L/min. No differences were seen in maximal fat oxidation in either skeletal muscle or adipose tissue. Km (app) for octanoyl carnitine or palmitoyl carnitine were similar after training in skeletal muscle and adipose tissue. Maximal OXPHOS capacity with complex I- and II-linked substrates was increased after training in skeletal muscle but not in adipose tissue. In conclusion, 6 weeks of HIT increased VO2peak . Mitochondrial content and mitochondrial OXPHOS capacity were increased in skeletal muscle, but not in adipose tissue. Furthermore, mitochondrial fat oxidation was not improved in either skeletal muscle or adipose tissue.

AB - High-intensity interval training (HIT) is known to increase mitochondrial content in a similar way as endurance training [60-90% of maximal oxygen uptake (VO2peak )]. Whether HIT increases the mitochondria's ability to oxidize lipids is currently debated. We investigated the effect of HIT on mitochondrial fat oxidation in skeletal muscle and adipose tissue. Mitochondrial oxidative phosphorylation (OXPHOS) capacity, mitochondrial substrate sensitivity (Km (app) ), and mitochondrial content were measured in skeletal muscle and adipose tissue in healthy overweight subjects before and after 6 weeks of HIT (three times per week at 298 ± 21 W). HIT significantly increased VO2peak from 2.9 ± 0.2 to 3.1 ± 0.2 L/min. No differences were seen in maximal fat oxidation in either skeletal muscle or adipose tissue. Km (app) for octanoyl carnitine or palmitoyl carnitine were similar after training in skeletal muscle and adipose tissue. Maximal OXPHOS capacity with complex I- and II-linked substrates was increased after training in skeletal muscle but not in adipose tissue. In conclusion, 6 weeks of HIT increased VO2peak . Mitochondrial content and mitochondrial OXPHOS capacity were increased in skeletal muscle, but not in adipose tissue. Furthermore, mitochondrial fat oxidation was not improved in either skeletal muscle or adipose tissue.

U2 - 10.1111/sms.12252

DO - 10.1111/sms.12252

M3 - Journal article

C2 - 24845952

VL - 25

SP - e59-e69

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 1

ER -

ID: 113988370