The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty

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Standard

The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn F; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendahl, Claus; Vilsboll, Tina; Knop, Filip K; Holst, Jens Juul.

I: American Journal of Physiology: Gastrointestinal and Liver Physiology, Bind 304, 18.04.2013, s. G1117-G1127.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Plamboeck, A, Veedfald, S, Deacon, CF, Hartmann, B, Wettergren, A, Svendsen, LB, Meisner, S, Hovendahl, C, Vilsboll, T, Knop, FK & Holst, JJ 2013, 'The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty', American Journal of Physiology: Gastrointestinal and Liver Physiology, bind 304, s. G1117-G1127. https://doi.org/10.1152/ajpgi.00035.2013

APA

Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., ... Holst, J. J. (2013). The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. American Journal of Physiology: Gastrointestinal and Liver Physiology, 304, G1117-G1127. https://doi.org/10.1152/ajpgi.00035.2013

Vancouver

Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Wettergren A, Svendsen LB o.a. The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2013 apr 18;304:G1117-G1127. https://doi.org/10.1152/ajpgi.00035.2013

Author

Plamboeck, Astrid ; Veedfald, Simon ; Deacon, Carolyn F ; Hartmann, Bolette ; Wettergren, Andre ; Svendsen, Lars Bo ; Meisner, Søren ; Hovendahl, Claus ; Vilsboll, Tina ; Knop, Filip K ; Holst, Jens Juul. / The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. I: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2013 ; Bind 304. s. G1117-G1127.

Bibtex

@article{aeeccc85dec44ad5a3356e9b441d54bf,
title = "The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty",
abstract = "Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 (DPP-4) suggests that endogenous GLP-1 may act locally before being degraded. Signalling via the vagus nerve was investigated in 20 truncally vagotomized subjects with pyloroplasty and 10 matched healthy controls. Subjects received GLP-1 (7-36 amide) or saline infusions during and after a standardized liquid mixed meal and a subsequent ad libitum meal. Despite no effect on appetite sensations, GLP-1 significantly reduced ad libitum food intake in the control group, but had no effect in the vagotomized group. Gastric emptying was accelerated in vagotomized subjects and was decreased by GLP-1 in controls but not in vagotomized subjects. Postprandial glucose levels were reduced by the same percentage by GLP-1 in both groups. Peak postprandial GLP-1 levels were ~5-fold higher in the vagotomized subjects. Insulin secretion was unaffected by exogenous GLP-1 in vagotomized subjects, but was suppressed in controls. GLP-1 significantly reduced glucagon secretion in both groups, but levels were ~2-fold higher, and non-suppressible in the early phase of the meal in vagotomized subjects. Our results demonstrate that vagotomy with pyloroplasty impairs the effects of exogenous GLP-1 on food intake, gastric emptying, insulin and glucagon secretion, suggesting that intact vagal innervation may be important for GLP-1's actions.",
author = "Astrid Plamboeck and Simon Veedfald and Deacon, {Carolyn F} and Bolette Hartmann and Andre Wettergren and Svendsen, {Lars Bo} and S{\o}ren Meisner and Claus Hovendahl and Tina Vilsboll and Knop, {Filip K} and Holst, {Jens Juul}",
year = "2013",
month = "4",
day = "18",
doi = "10.1152/ajpgi.00035.2013",
language = "English",
volume = "304",
pages = "G1117--G1127",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",

}

RIS

TY - JOUR

T1 - The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty

AU - Plamboeck, Astrid

AU - Veedfald, Simon

AU - Deacon, Carolyn F

AU - Hartmann, Bolette

AU - Wettergren, Andre

AU - Svendsen, Lars Bo

AU - Meisner, Søren

AU - Hovendahl, Claus

AU - Vilsboll, Tina

AU - Knop, Filip K

AU - Holst, Jens Juul

PY - 2013/4/18

Y1 - 2013/4/18

N2 - Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 (DPP-4) suggests that endogenous GLP-1 may act locally before being degraded. Signalling via the vagus nerve was investigated in 20 truncally vagotomized subjects with pyloroplasty and 10 matched healthy controls. Subjects received GLP-1 (7-36 amide) or saline infusions during and after a standardized liquid mixed meal and a subsequent ad libitum meal. Despite no effect on appetite sensations, GLP-1 significantly reduced ad libitum food intake in the control group, but had no effect in the vagotomized group. Gastric emptying was accelerated in vagotomized subjects and was decreased by GLP-1 in controls but not in vagotomized subjects. Postprandial glucose levels were reduced by the same percentage by GLP-1 in both groups. Peak postprandial GLP-1 levels were ~5-fold higher in the vagotomized subjects. Insulin secretion was unaffected by exogenous GLP-1 in vagotomized subjects, but was suppressed in controls. GLP-1 significantly reduced glucagon secretion in both groups, but levels were ~2-fold higher, and non-suppressible in the early phase of the meal in vagotomized subjects. Our results demonstrate that vagotomy with pyloroplasty impairs the effects of exogenous GLP-1 on food intake, gastric emptying, insulin and glucagon secretion, suggesting that intact vagal innervation may be important for GLP-1's actions.

AB - Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 (DPP-4) suggests that endogenous GLP-1 may act locally before being degraded. Signalling via the vagus nerve was investigated in 20 truncally vagotomized subjects with pyloroplasty and 10 matched healthy controls. Subjects received GLP-1 (7-36 amide) or saline infusions during and after a standardized liquid mixed meal and a subsequent ad libitum meal. Despite no effect on appetite sensations, GLP-1 significantly reduced ad libitum food intake in the control group, but had no effect in the vagotomized group. Gastric emptying was accelerated in vagotomized subjects and was decreased by GLP-1 in controls but not in vagotomized subjects. Postprandial glucose levels were reduced by the same percentage by GLP-1 in both groups. Peak postprandial GLP-1 levels were ~5-fold higher in the vagotomized subjects. Insulin secretion was unaffected by exogenous GLP-1 in vagotomized subjects, but was suppressed in controls. GLP-1 significantly reduced glucagon secretion in both groups, but levels were ~2-fold higher, and non-suppressible in the early phase of the meal in vagotomized subjects. Our results demonstrate that vagotomy with pyloroplasty impairs the effects of exogenous GLP-1 on food intake, gastric emptying, insulin and glucagon secretion, suggesting that intact vagal innervation may be important for GLP-1's actions.

U2 - 10.1152/ajpgi.00035.2013

DO - 10.1152/ajpgi.00035.2013

M3 - Journal article

C2 - 23599045

VL - 304

SP - G1117-G1127

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

ER -

ID: 45840065