The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging

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Standard

The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging. / Lee, Blaire; Postnov, Dmitry D; Sørensen, Charlotte M; Sosnovtseva, Olga.

I: Physiological Reports, Bind 11, Nr. 6, e15648, 03.2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, B, Postnov, DD, Sørensen, CM & Sosnovtseva, O 2023, 'The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging', Physiological Reports, bind 11, nr. 6, e15648. https://doi.org/10.14814/phy2.15648

APA

Lee, B., Postnov, D. D., Sørensen, C. M., & Sosnovtseva, O. (2023). The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging. Physiological Reports, 11(6), [e15648]. https://doi.org/10.14814/phy2.15648

Vancouver

Lee B, Postnov DD, Sørensen CM, Sosnovtseva O. The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging. Physiological Reports. 2023 mar.;11(6). e15648. https://doi.org/10.14814/phy2.15648

Author

Lee, Blaire ; Postnov, Dmitry D ; Sørensen, Charlotte M ; Sosnovtseva, Olga. / The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging. I: Physiological Reports. 2023 ; Bind 11, Nr. 6.

Bibtex

@article{fb752075498d495f9bd18a247583c8bf,
title = "The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging",
abstract = "The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.",
keywords = "Rats, Animals, Rats, Sprague-Dawley, Neurovascular Coupling, Feedback, Microcirculation, Glomerular Filtration Rate/physiology, Sodium/metabolism, Symporters, Glucose, Kidney Tubules/metabolism",
author = "Blaire Lee and Postnov, {Dmitry D} and S{\o}rensen, {Charlotte M} and Olga Sosnovtseva",
note = "{\textcopyright} 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.",
year = "2023",
month = mar,
doi = "10.14814/phy2.15648",
language = "English",
volume = "11",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging

AU - Lee, Blaire

AU - Postnov, Dmitry D

AU - Sørensen, Charlotte M

AU - Sosnovtseva, Olga

N1 - © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

PY - 2023/3

Y1 - 2023/3

N2 - The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.

AB - The tubuloglomerular feedback (TGF) mechanism modulates renal hemodynamics and glomerular filtration rate in individual nephrons. Our study aimed to evaluate the TGF-induced vascular responses by inhibiting Na-K-2Cl co-transporters and sodium-glucose co-transporters in rats. We assessed cortical hemodynamics with high-resolution laser speckle contrast imaging, which enabled the evaluation of blood flow in individual microvessels and analysis of their dynamical patterns in the time-frequency domain. We demonstrated that a systemic administration of furosemide abolishes TGF-mediated hemodynamic responses. Furthermore, we showed that the local microcirculatory blood flow decreased, and the TGF-induced hemodynamic oscillations were sustained but weakened after inhibiting sodium-glucose co-transporters in Sprague-Dawley rats.

KW - Rats

KW - Animals

KW - Rats, Sprague-Dawley

KW - Neurovascular Coupling

KW - Feedback

KW - Microcirculation

KW - Glomerular Filtration Rate/physiology

KW - Sodium/metabolism

KW - Symporters

KW - Glucose

KW - Kidney Tubules/metabolism

U2 - 10.14814/phy2.15648

DO - 10.14814/phy2.15648

M3 - Journal article

C2 - 36949667

VL - 11

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 6

M1 - e15648

ER -

ID: 340528543