The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Bas W C Arkensteijn, Jimmy F P Berbée, Patrick C N Rensen, Lars B Nielsen, Christina Christoffersen

Apolipoprotein M (apoM) is a plasma apolipoprotein that mainly associates with high-density lipoproteins. Hence, most studies on apoM so far have investigated its effect on and association with lipid metabolism and atherosclerosis. The insight into apoM biology recently took a major turn. ApoM was identified as a carrier of the bioactive lipid sphingosine-1-phosphate (S1P). S1P activates five different G-protein-coupled receptors, known as the S1P-receptors 1-5 and, hence, affects a wide range of biological processes, such as lymphocyte trafficking, angiogenesis, wound repair and even virus suppression and cancer. The ability of apoM to bind S1P is due to a lipophilic binding pocket within the lipocalin structure of the apoM molecule. Mice overexpressing apoM have increased plasma S1P concentrations, whereas apoM-deficient mice have decreased S1P levels. ApoM-S1P is able to activate the S1P-receptor-1, affecting the function of endothelial cells, and apoM-deficient mice display impaired endothelial permeability in the lung. This review will focus on the putative biological roles of the new apoM-S1P axis in relation to lipoprotein metabolism, lipid disorders and atherosclerosis.
OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences (Online)
Vol/bind14
Udgave nummer3
Sider (fra-til)4419-31
Antal sider13
ISSN1661-6596
DOI
StatusUdgivet - 25 feb. 2013

ID: 100888219