Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study

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Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women : A preliminary study. / Skov-Jeppesen, Kirsa; Veedfald, Simon; Madsbad, Sten; Holst, Jens Juul; Rosenkilde, Mette Marie; Hartmann, Bolette.

I: Bone, Bind 152, 116065, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Skov-Jeppesen, K, Veedfald, S, Madsbad, S, Holst, JJ, Rosenkilde, MM & Hartmann, B 2021, 'Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study', Bone, bind 152, 116065. https://doi.org/10.1016/j.bone.2021.116065

APA

Skov-Jeppesen, K., Veedfald, S., Madsbad, S., Holst, J. J., Rosenkilde, M. M., & Hartmann, B. (2021). Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study. Bone, 152, [116065]. https://doi.org/10.1016/j.bone.2021.116065

Vancouver

Skov-Jeppesen K, Veedfald S, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B. Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study. Bone. 2021;152. 116065. https://doi.org/10.1016/j.bone.2021.116065

Author

Skov-Jeppesen, Kirsa ; Veedfald, Simon ; Madsbad, Sten ; Holst, Jens Juul ; Rosenkilde, Mette Marie ; Hartmann, Bolette. / Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women : A preliminary study. I: Bone. 2021 ; Bind 152.

Bibtex

@article{fc7ad12ffee945bf8dee2bc1958eac09,
title = "Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study",
abstract = "BACKGROUND: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted in response to food ingestion, and they have been suggested to regulate bone turnover. In humans, exogenous GIP and GLP-2 acutely inhibit bone resorption as measured by circulating levels of carboxy-terminal type 1 collagen crosslinks (CTX).OBJECTIVE: The objective was to study the individual and combined acute effects of GIP and GLP-2 on bone turnover in postmenopausal women during nighttime - a period of increased bone resorption.METHODS: Using a randomized, placebo-controlled, double-blinded, crossover design, each participant (n = 9) received on four separate study days: GIP, GLP-2, GIP + GLP-2, and placebo (saline) as subcutaneous injections at bedtime. Main outcomes were levels of CTX and procollagen type 1 N-terminal propeptide (P1NP).RESULTS: Compared with placebo, GIP and GLP-2 alone significantly inhibited bone resorption (measured by CTX). GIP rapidly reduced CTX levels in the period from 45 to 120 min after injection, while GLP-2 had a more delayed effect with reduced CTX levels in the period from 120 to 240 min after injection. Combining GIP and GLP-2 showed complementary effects resulting in a sustained inhibition of CTX with reduced levels from 45 to 240 min after injection. Furthermore, GIP acutely increased bone formation (measured by P1NP).CONCLUSION: Both GIP and GLP-2 reduced CTX during the night and had complementary effects when combined.",
author = "Kirsa Skov-Jeppesen and Simon Veedfald and Sten Madsbad and Holst, {Jens Juul} and Rosenkilde, {Mette Marie} and Bolette Hartmann",
note = "Copyright {\textcopyright} 2021 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2021",
doi = "10.1016/j.bone.2021.116065",
language = "English",
volume = "152",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women

T2 - A preliminary study

AU - Skov-Jeppesen, Kirsa

AU - Veedfald, Simon

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Rosenkilde, Mette Marie

AU - Hartmann, Bolette

N1 - Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted in response to food ingestion, and they have been suggested to regulate bone turnover. In humans, exogenous GIP and GLP-2 acutely inhibit bone resorption as measured by circulating levels of carboxy-terminal type 1 collagen crosslinks (CTX).OBJECTIVE: The objective was to study the individual and combined acute effects of GIP and GLP-2 on bone turnover in postmenopausal women during nighttime - a period of increased bone resorption.METHODS: Using a randomized, placebo-controlled, double-blinded, crossover design, each participant (n = 9) received on four separate study days: GIP, GLP-2, GIP + GLP-2, and placebo (saline) as subcutaneous injections at bedtime. Main outcomes were levels of CTX and procollagen type 1 N-terminal propeptide (P1NP).RESULTS: Compared with placebo, GIP and GLP-2 alone significantly inhibited bone resorption (measured by CTX). GIP rapidly reduced CTX levels in the period from 45 to 120 min after injection, while GLP-2 had a more delayed effect with reduced CTX levels in the period from 120 to 240 min after injection. Combining GIP and GLP-2 showed complementary effects resulting in a sustained inhibition of CTX with reduced levels from 45 to 240 min after injection. Furthermore, GIP acutely increased bone formation (measured by P1NP).CONCLUSION: Both GIP and GLP-2 reduced CTX during the night and had complementary effects when combined.

AB - BACKGROUND: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted in response to food ingestion, and they have been suggested to regulate bone turnover. In humans, exogenous GIP and GLP-2 acutely inhibit bone resorption as measured by circulating levels of carboxy-terminal type 1 collagen crosslinks (CTX).OBJECTIVE: The objective was to study the individual and combined acute effects of GIP and GLP-2 on bone turnover in postmenopausal women during nighttime - a period of increased bone resorption.METHODS: Using a randomized, placebo-controlled, double-blinded, crossover design, each participant (n = 9) received on four separate study days: GIP, GLP-2, GIP + GLP-2, and placebo (saline) as subcutaneous injections at bedtime. Main outcomes were levels of CTX and procollagen type 1 N-terminal propeptide (P1NP).RESULTS: Compared with placebo, GIP and GLP-2 alone significantly inhibited bone resorption (measured by CTX). GIP rapidly reduced CTX levels in the period from 45 to 120 min after injection, while GLP-2 had a more delayed effect with reduced CTX levels in the period from 120 to 240 min after injection. Combining GIP and GLP-2 showed complementary effects resulting in a sustained inhibition of CTX with reduced levels from 45 to 240 min after injection. Furthermore, GIP acutely increased bone formation (measured by P1NP).CONCLUSION: Both GIP and GLP-2 reduced CTX during the night and had complementary effects when combined.

U2 - 10.1016/j.bone.2021.116065

DO - 10.1016/j.bone.2021.116065

M3 - Journal article

C2 - 34153529

VL - 152

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 116065

ER -

ID: 275886501