Serial troponin-T and long-term outcomes in suspected acute coronary syndrome

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Serial troponin-T and long-term outcomes in suspected acute coronary syndrome. / Pareek, Manan; Kragholm, Kristian H.; Kristensen, Anna Meta Dyrvig; Vaduganathan, Muthiah; Pallisgaard, Jannik L.; Byrne, Christina; Biering-Sorensen, Tor; Lee, Christina Ji-Young; Bonde, Anders Nissen; Mortensen, Martin Bodtker; Maeng, Michael; Fosbol, Emil L.; Kober, Lars; Olsen, Niels Thue; Gislason, Gunnar H.; Bhatt, Deepak L.; Torp-Pedersen, Christian.

I: European Heart Journal, Bind 44, Nr. 6, 2023, s. 502–512.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pareek, M, Kragholm, KH, Kristensen, AMD, Vaduganathan, M, Pallisgaard, JL, Byrne, C, Biering-Sorensen, T, Lee, CJ-Y, Bonde, AN, Mortensen, MB, Maeng, M, Fosbol, EL, Kober, L, Olsen, NT, Gislason, GH, Bhatt, DL & Torp-Pedersen, C 2023, 'Serial troponin-T and long-term outcomes in suspected acute coronary syndrome', European Heart Journal, bind 44, nr. 6, s. 502–512. https://doi.org/10.1093/eurheartj/ehac629

APA

Pareek, M., Kragholm, K. H., Kristensen, A. M. D., Vaduganathan, M., Pallisgaard, J. L., Byrne, C., Biering-Sorensen, T., Lee, C. J-Y., Bonde, A. N., Mortensen, M. B., Maeng, M., Fosbol, E. L., Kober, L., Olsen, N. T., Gislason, G. H., Bhatt, D. L., & Torp-Pedersen, C. (2023). Serial troponin-T and long-term outcomes in suspected acute coronary syndrome. European Heart Journal, 44(6), 502–512. https://doi.org/10.1093/eurheartj/ehac629

Vancouver

Pareek M, Kragholm KH, Kristensen AMD, Vaduganathan M, Pallisgaard JL, Byrne C o.a. Serial troponin-T and long-term outcomes in suspected acute coronary syndrome. European Heart Journal. 2023;44(6):502–512. https://doi.org/10.1093/eurheartj/ehac629

Author

Pareek, Manan ; Kragholm, Kristian H. ; Kristensen, Anna Meta Dyrvig ; Vaduganathan, Muthiah ; Pallisgaard, Jannik L. ; Byrne, Christina ; Biering-Sorensen, Tor ; Lee, Christina Ji-Young ; Bonde, Anders Nissen ; Mortensen, Martin Bodtker ; Maeng, Michael ; Fosbol, Emil L. ; Kober, Lars ; Olsen, Niels Thue ; Gislason, Gunnar H. ; Bhatt, Deepak L. ; Torp-Pedersen, Christian. / Serial troponin-T and long-term outcomes in suspected acute coronary syndrome. I: European Heart Journal. 2023 ; Bind 44, Nr. 6. s. 502–512.

Bibtex

@article{47305e19598d4debaee941bb7cd44b7c,
title = "Serial troponin-T and long-term outcomes in suspected acute coronary syndrome",
abstract = "Background Long-term prognostic implications of serial high-sensitivity troponin concentrations in subjects with suspected acute coronary syndrome are unknown. Methods and results Individuals with a first diagnosis of myocardial infarction, unstable angina, observation for suspected myocardial infarction, or chest pain from 2012 through 2019 who underwent two high-sensitivity troponin-T (hsTnT) measurements 1-7 h apart were identified through Danish national registries. Absolute and relative risks for death at days 0-30 and 31-365, stratified for whether subjects had normal or elevated hsTnT concentrations, and whether these concentrations changed by 20 to 50%, or >50% in either direction from first to second measurement, were calculated through multivariable logistic regression with average treatment effect modeling. Of the 28 902 individuals included, 2.8% had died at 30 days, whereas 4.9% of those who had survived the first 30 days died between days 31-365. The standardized risk of death was highest among subjects with two elevated hsTnT concentrations (0-30 days: 4.3%, 31-365 days: 7.2%). In this group, mortality was significantly higher in those with a > 20 to 50% or >50% rise from first to second measurement, though only at 30 days. The risk of death was very low in subjects with two normal hsTnT concentrations (0-30 days: 0.1%, 31-365 days: 0.9%) and did not depend on relative or absolute changes between measurements. Conclusions Individuals with suspected acute coronary syndrome and two consecutively elevated hsTnT concentrations consistently had the highest risk of death. Mortality was very low in subjects with two normal hsTnT concentrations, irrespective of changes between measurements.",
keywords = "Acute coronary syndrome, Biomarkers, Mortality, Myocardial infarction, Troponin-T, ACUTE MYOCARDIAL-INFARCTION, HIGH-SENSITIVITY TROPONIN, RULE-OUT, EUROPEAN-SOCIETY, CARDIAC TROPONINS, CT ANGIOGRAPHY, TASK-FORCE, ELEVATION, DIAGNOSES, ASSOCIATION",
author = "Manan Pareek and Kragholm, {Kristian H.} and Kristensen, {Anna Meta Dyrvig} and Muthiah Vaduganathan and Pallisgaard, {Jannik L.} and Christina Byrne and Tor Biering-Sorensen and Lee, {Christina Ji-Young} and Bonde, {Anders Nissen} and Mortensen, {Martin Bodtker} and Michael Maeng and Fosbol, {Emil L.} and Lars Kober and Olsen, {Niels Thue} and Gislason, {Gunnar H.} and Bhatt, {Deepak L.} and Christian Torp-Pedersen",
year = "2023",
doi = "10.1093/eurheartj/ehac629",
language = "English",
volume = "44",
pages = "502–512",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Serial troponin-T and long-term outcomes in suspected acute coronary syndrome

AU - Pareek, Manan

AU - Kragholm, Kristian H.

AU - Kristensen, Anna Meta Dyrvig

AU - Vaduganathan, Muthiah

AU - Pallisgaard, Jannik L.

AU - Byrne, Christina

AU - Biering-Sorensen, Tor

AU - Lee, Christina Ji-Young

AU - Bonde, Anders Nissen

AU - Mortensen, Martin Bodtker

AU - Maeng, Michael

AU - Fosbol, Emil L.

AU - Kober, Lars

AU - Olsen, Niels Thue

AU - Gislason, Gunnar H.

AU - Bhatt, Deepak L.

AU - Torp-Pedersen, Christian

PY - 2023

Y1 - 2023

N2 - Background Long-term prognostic implications of serial high-sensitivity troponin concentrations in subjects with suspected acute coronary syndrome are unknown. Methods and results Individuals with a first diagnosis of myocardial infarction, unstable angina, observation for suspected myocardial infarction, or chest pain from 2012 through 2019 who underwent two high-sensitivity troponin-T (hsTnT) measurements 1-7 h apart were identified through Danish national registries. Absolute and relative risks for death at days 0-30 and 31-365, stratified for whether subjects had normal or elevated hsTnT concentrations, and whether these concentrations changed by 20 to 50%, or >50% in either direction from first to second measurement, were calculated through multivariable logistic regression with average treatment effect modeling. Of the 28 902 individuals included, 2.8% had died at 30 days, whereas 4.9% of those who had survived the first 30 days died between days 31-365. The standardized risk of death was highest among subjects with two elevated hsTnT concentrations (0-30 days: 4.3%, 31-365 days: 7.2%). In this group, mortality was significantly higher in those with a > 20 to 50% or >50% rise from first to second measurement, though only at 30 days. The risk of death was very low in subjects with two normal hsTnT concentrations (0-30 days: 0.1%, 31-365 days: 0.9%) and did not depend on relative or absolute changes between measurements. Conclusions Individuals with suspected acute coronary syndrome and two consecutively elevated hsTnT concentrations consistently had the highest risk of death. Mortality was very low in subjects with two normal hsTnT concentrations, irrespective of changes between measurements.

AB - Background Long-term prognostic implications of serial high-sensitivity troponin concentrations in subjects with suspected acute coronary syndrome are unknown. Methods and results Individuals with a first diagnosis of myocardial infarction, unstable angina, observation for suspected myocardial infarction, or chest pain from 2012 through 2019 who underwent two high-sensitivity troponin-T (hsTnT) measurements 1-7 h apart were identified through Danish national registries. Absolute and relative risks for death at days 0-30 and 31-365, stratified for whether subjects had normal or elevated hsTnT concentrations, and whether these concentrations changed by 20 to 50%, or >50% in either direction from first to second measurement, were calculated through multivariable logistic regression with average treatment effect modeling. Of the 28 902 individuals included, 2.8% had died at 30 days, whereas 4.9% of those who had survived the first 30 days died between days 31-365. The standardized risk of death was highest among subjects with two elevated hsTnT concentrations (0-30 days: 4.3%, 31-365 days: 7.2%). In this group, mortality was significantly higher in those with a > 20 to 50% or >50% rise from first to second measurement, though only at 30 days. The risk of death was very low in subjects with two normal hsTnT concentrations (0-30 days: 0.1%, 31-365 days: 0.9%) and did not depend on relative or absolute changes between measurements. Conclusions Individuals with suspected acute coronary syndrome and two consecutively elevated hsTnT concentrations consistently had the highest risk of death. Mortality was very low in subjects with two normal hsTnT concentrations, irrespective of changes between measurements.

KW - Acute coronary syndrome

KW - Biomarkers

KW - Mortality

KW - Myocardial infarction

KW - Troponin-T

KW - ACUTE MYOCARDIAL-INFARCTION

KW - HIGH-SENSITIVITY TROPONIN

KW - RULE-OUT

KW - EUROPEAN-SOCIETY

KW - CARDIAC TROPONINS

KW - CT ANGIOGRAPHY

KW - TASK-FORCE

KW - ELEVATION

KW - DIAGNOSES

KW - ASSOCIATION

U2 - 10.1093/eurheartj/ehac629

DO - 10.1093/eurheartj/ehac629

M3 - Journal article

C2 - 36329643

VL - 44

SP - 502

EP - 512

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 6

ER -

ID: 326631797