Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
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Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. / Indo, Hiroko P.; Hawkins, Clare L; Nakanishi, Ikuo; Matsumoto, Ken-Ichiro; Matsui, Hirofumi; Suenaga, Shigeaki; Davies, Michael J; St Clair, Daret K; Ozawa, Toshihiko; Majima, Hideyuki J.
Pharmacology of Mitochondria. Bind 240 Springer, 2017. s. 439-456 (Handbook of Experimental Pharmacology, Bind 240).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
AU - Indo, Hiroko P.
AU - Hawkins, Clare L
AU - Nakanishi, Ikuo
AU - Matsumoto, Ken-Ichiro
AU - Matsui, Hirofumi
AU - Suenaga, Shigeaki
AU - Davies, Michael J
AU - St Clair, Daret K
AU - Ozawa, Toshihiko
AU - Majima, Hideyuki J.
PY - 2017
Y1 - 2017
N2 - Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.
AB - Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.
KW - Journal Article
U2 - 10.1007/164_2016_117
DO - 10.1007/164_2016_117
M3 - Book chapter
C2 - 28176043
SN - 978-3-319-57311-3
VL - 240
T3 - Handbook of Experimental Pharmacology
SP - 439
EP - 456
BT - Pharmacology of Mitochondria
PB - Springer
ER -
ID: 182331246