Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial
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Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial. / Sjúrðarson, Tórur; Bejder, Jacob; Breenfeldt Andersen, Andreas; Bonne, Thomas Christian; Kyhl, Kasper; Thomassen, Martin; Prats, Júlia; Oddmarsdóttir Gregersen, Noomi; Skoradal, May-Britt; Weihe, Pál; Nordsborg, Nikolai Baastrup; Mohr, Magni.
I: European Journal of Applied Physiology, Bind 123, Nr. 2, 2023, s. 325-337.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial
AU - Sjúrðarson, Tórur
AU - Bejder, Jacob
AU - Breenfeldt Andersen, Andreas
AU - Bonne, Thomas Christian
AU - Kyhl, Kasper
AU - Thomassen, Martin
AU - Prats, Júlia
AU - Oddmarsdóttir Gregersen, Noomi
AU - Skoradal, May-Britt
AU - Weihe, Pál
AU - Nordsborg, Nikolai Baastrup
AU - Mohr, Magni
N1 - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Purpose: Angiotensin-converting enzyme (ACE) inhibitor treatment is widely applied, but the fact that plasma ACE activity is a potential determinant of training-induced local muscular adaptability is often neglected. Thus, we investigated the hypothesis that ACE inhibition modulates the response to systematic aerobic exercise training on leg and arm muscular adaptations.Methods: Healthy, untrained, middle-aged participants (40 ± 7 yrs) completed a randomized, double-blinded, placebo-controlled trial. Participants were randomized to placebo (PLA: CaCO3) or ACE inhibitor (ACEi: enalapril) for 8 weeks and completed a supervised, high-intensity exercise training program. Muscular characteristics in the leg and arm were extensively evaluated pre and post-intervention. Results: Forty-eight participants (nACEi = 23, nPLA = 25) completed the trial. Exercise training compliance was above 99%. After training, citrate synthase, 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity were increased in m. vastus lateralis in both groups (all P < 0.05) without statistical differences between them (all time × treatment P > 0.05). In m. deltoideus, citrate synthase maximal activity was upregulated to a greater extent (time × treatment P < 0.05) in PLA (51 [33;69] %) than in ACEi (28 [13;43] %), but the change in 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity was similar between groups. Finally, the training-induced changes in the platelet endothelial cell adhesion molecule-1 protein abundance, a marker of capillary density, were similar in both groups in m. vastus lateralis and m. deltoideus. Conclusion: Eight weeks of high-intensity whole-body exercise training improves markers of skeletal muscle mitochondrial oxidative capacity, glycolytic capacity and angiogenesis, with no overall effect of pharmacological ACE inhibition in healthy adults.
AB - Purpose: Angiotensin-converting enzyme (ACE) inhibitor treatment is widely applied, but the fact that plasma ACE activity is a potential determinant of training-induced local muscular adaptability is often neglected. Thus, we investigated the hypothesis that ACE inhibition modulates the response to systematic aerobic exercise training on leg and arm muscular adaptations.Methods: Healthy, untrained, middle-aged participants (40 ± 7 yrs) completed a randomized, double-blinded, placebo-controlled trial. Participants were randomized to placebo (PLA: CaCO3) or ACE inhibitor (ACEi: enalapril) for 8 weeks and completed a supervised, high-intensity exercise training program. Muscular characteristics in the leg and arm were extensively evaluated pre and post-intervention. Results: Forty-eight participants (nACEi = 23, nPLA = 25) completed the trial. Exercise training compliance was above 99%. After training, citrate synthase, 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity were increased in m. vastus lateralis in both groups (all P < 0.05) without statistical differences between them (all time × treatment P > 0.05). In m. deltoideus, citrate synthase maximal activity was upregulated to a greater extent (time × treatment P < 0.05) in PLA (51 [33;69] %) than in ACEi (28 [13;43] %), but the change in 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity was similar between groups. Finally, the training-induced changes in the platelet endothelial cell adhesion molecule-1 protein abundance, a marker of capillary density, were similar in both groups in m. vastus lateralis and m. deltoideus. Conclusion: Eight weeks of high-intensity whole-body exercise training improves markers of skeletal muscle mitochondrial oxidative capacity, glycolytic capacity and angiogenesis, with no overall effect of pharmacological ACE inhibition in healthy adults.
KW - Faculty of Science
KW - Angiotensin-converting enzyme inhibitors
KW - Muscle oxidative capacity
KW - High-intensity interval training
KW - Muscle-specific adaptations
KW - Angiogenesis
U2 - 10.1007/s00421-022-05072-5
DO - 10.1007/s00421-022-05072-5
M3 - Journal article
C2 - 36271942
VL - 123
SP - 325
EP - 337
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
SN - 1439-6319
IS - 2
ER -
ID: 323614448