Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe a novel piperidine-based compound with structural similarity to previously described CCR8-specific agonists, but containing a unique phenyl-tetrazol moiety which, in addition to activity at CCR8 was also active at CCR1.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 166 |
Udgave nummer | 1 |
Sider (fra-til) | 258-75 |
Antal sider | 18 |
ISSN | 0007-1188 |
DOI | |
Status | Udgivet - maj 2012 |
ID: 48972161