Reference values for leptin/adiponectin ratio in healthy children and adolescents
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Reference values for leptin/adiponectin ratio in healthy children and adolescents. / Lausten-Thomsen, Ulrik; Lund, Morten Asp Vonsild; Frithioff-Bojsoe, Christine; Hedley, Paula Louise; Pedersen, Oluf; Hansen, Torben; Christiansen, Michael; Holm, Jens-Christian.
I: Clinica Chimica Acta, Bind 493, 2019, s. 123-128.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Reference values for leptin/adiponectin ratio in healthy children and adolescents
AU - Lausten-Thomsen, Ulrik
AU - Lund, Morten Asp Vonsild
AU - Frithioff-Bojsoe, Christine
AU - Hedley, Paula Louise
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Christiansen, Michael
AU - Holm, Jens-Christian
PY - 2019
Y1 - 2019
N2 - Background: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios. Methods: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits. Results: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p <.001). Conclusion: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents
AB - Background: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios. Methods: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits. Results: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p <.001). Conclusion: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents
KW - Adipokines
KW - Adiponectin
KW - Biomarkers
KW - Children
KW - Leptin
KW - Reference values
U2 - 10.1016/j.cca.2019.03.004
DO - 10.1016/j.cca.2019.03.004
M3 - Journal article
C2 - 30849308
VL - 493
SP - 123
EP - 128
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -
ID: 228533951