Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children

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Standard

Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children. / Halling, Anne Sofie; Fritz, Blaine Gabriel; Gerner, Trine; Rinnov, Maria Rasmussen; Bay, Lene; Knudgaard, Mette Hjorslev; Ravn, Nina Haarup; Trautner, Simon; Ruge, Iben Frier; Olesen, Caroline; Díiaz-Pinées Cort, Isabel; Skov, Lone; Sørensen, Nikolaj; Møller Rønnstad, Amalie Thorsti; Thomsen, Simon F.; Egeberg, Alexander; Jakasa, Ivone; Kezic, Sanja; Bjarnsholt, Thomas; Thyssen, Jacob P.

I: Journal of Investigative Dermatology, Bind 143, Nr. 10, 2023, s. 2030-2038.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Halling, AS, Fritz, BG, Gerner, T, Rinnov, MR, Bay, L, Knudgaard, MH, Ravn, NH, Trautner, S, Ruge, IF, Olesen, C, Díiaz-Pinées Cort, I, Skov, L, Sørensen, N, Møller Rønnstad, AT, Thomsen, SF, Egeberg, A, Jakasa, I, Kezic, S, Bjarnsholt, T & Thyssen, JP 2023, 'Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children', Journal of Investigative Dermatology, bind 143, nr. 10, s. 2030-2038. https://doi.org/10.1016/j.jid.2023.03.1682

APA

Halling, A. S., Fritz, B. G., Gerner, T., Rinnov, M. R., Bay, L., Knudgaard, M. H., Ravn, N. H., Trautner, S., Ruge, I. F., Olesen, C., Díiaz-Pinées Cort, I., Skov, L., Sørensen, N., Møller Rønnstad, A. T., Thomsen, S. F., Egeberg, A., Jakasa, I., Kezic, S., Bjarnsholt, T., & Thyssen, J. P. (2023). Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children. Journal of Investigative Dermatology, 143(10), 2030-2038. https://doi.org/10.1016/j.jid.2023.03.1682

Vancouver

Halling AS, Fritz BG, Gerner T, Rinnov MR, Bay L, Knudgaard MH o.a. Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children. Journal of Investigative Dermatology. 2023;143(10):2030-2038. https://doi.org/10.1016/j.jid.2023.03.1682

Author

Halling, Anne Sofie ; Fritz, Blaine Gabriel ; Gerner, Trine ; Rinnov, Maria Rasmussen ; Bay, Lene ; Knudgaard, Mette Hjorslev ; Ravn, Nina Haarup ; Trautner, Simon ; Ruge, Iben Frier ; Olesen, Caroline ; Díiaz-Pinées Cort, Isabel ; Skov, Lone ; Sørensen, Nikolaj ; Møller Rønnstad, Amalie Thorsti ; Thomsen, Simon F. ; Egeberg, Alexander ; Jakasa, Ivone ; Kezic, Sanja ; Bjarnsholt, Thomas ; Thyssen, Jacob P. / Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children. I: Journal of Investigative Dermatology. 2023 ; Bind 143, Nr. 10. s. 2030-2038.

Bibtex

@article{8c6ca2277b524d6ca7b86d205466273c,

title = "Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children",

abstract = "It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we examined whether skin microbiome alterations during the first 2 months of life were associated with an increased risk of AD in the first 2 years and its severity after adjustment for environmental factors and selected skin chemokine and natural moisturizing factor levels. We found no overall association between the skin microbiome at birth and age 2 months and AD during the first 2 years of life. However, when restricting the analysis to children with at least one parent with atopy, a lower alpha diversity at age 2 months was associated with an increased risk of AD (adjusted hazard ratio = 1.7, 95% confidence interval = 1.1–2.6). We observed a stronger association in children where both parents had atopy (adjusted hazard ratio = 4.4, 95% confidence interval = 1.1–18.2). The putative pathogenic role of changes in the skin microbiome on AD risk remains uncertain but may play a role in those with an atopic predisposition.",

author = "Halling, {Anne Sofie} and Fritz, {Blaine Gabriel} and Trine Gerner and Rinnov, {Maria Rasmussen} and Lene Bay and Knudgaard, {Mette Hjorslev} and Ravn, {Nina Haarup} and Simon Trautner and Ruge, {Iben Frier} and Caroline Olesen and {D{\'i}iaz-Pin{\'e}es Cort}, Isabel and Lone Skov and Nikolaj S{\o}rensen and {M{\o}ller R{\o}nnstad}, {Amalie Thorsti} and Thomsen, {Simon F.} and Alexander Egeberg and Ivone Jakasa and Sanja Kezic and Thomas Bjarnsholt and Thyssen, {Jacob P.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

doi = "10.1016/j.jid.2023.03.1682",

language = "English",

volume = "143",

pages = "2030--2038",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "nature publishing group",

number = "10",

}

RIS

TY - JOUR

T1 - Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children

AU - Halling, Anne Sofie

AU - Fritz, Blaine Gabriel

AU - Gerner, Trine

AU - Rinnov, Maria Rasmussen

AU - Bay, Lene

AU - Knudgaard, Mette Hjorslev

AU - Ravn, Nina Haarup

AU - Trautner, Simon

AU - Ruge, Iben Frier

AU - Olesen, Caroline

AU - Díiaz-Pinées Cort, Isabel

AU - Skov, Lone

AU - Sørensen, Nikolaj

AU - Møller Rønnstad, Amalie Thorsti

AU - Thomsen, Simon F.

AU - Egeberg, Alexander

AU - Jakasa, Ivone

AU - Kezic, Sanja

AU - Bjarnsholt, Thomas

AU - Thyssen, Jacob P.

PY - 2023

Y1 - 2023

N2 - It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we examined whether skin microbiome alterations during the first 2 months of life were associated with an increased risk of AD in the first 2 years and its severity after adjustment for environmental factors and selected skin chemokine and natural moisturizing factor levels. We found no overall association between the skin microbiome at birth and age 2 months and AD during the first 2 years of life. However, when restricting the analysis to children with at least one parent with atopy, a lower alpha diversity at age 2 months was associated with an increased risk of AD (adjusted hazard ratio = 1.7, 95% confidence interval = 1.1–2.6). We observed a stronger association in children where both parents had atopy (adjusted hazard ratio = 4.4, 95% confidence interval = 1.1–18.2). The putative pathogenic role of changes in the skin microbiome on AD risk remains uncertain but may play a role in those with an atopic predisposition.

AB - It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we examined whether skin microbiome alterations during the first 2 months of life were associated with an increased risk of AD in the first 2 years and its severity after adjustment for environmental factors and selected skin chemokine and natural moisturizing factor levels. We found no overall association between the skin microbiome at birth and age 2 months and AD during the first 2 years of life. However, when restricting the analysis to children with at least one parent with atopy, a lower alpha diversity at age 2 months was associated with an increased risk of AD (adjusted hazard ratio = 1.7, 95% confidence interval = 1.1–2.6). We observed a stronger association in children where both parents had atopy (adjusted hazard ratio = 4.4, 95% confidence interval = 1.1–18.2). The putative pathogenic role of changes in the skin microbiome on AD risk remains uncertain but may play a role in those with an atopic predisposition.

U2 - 10.1016/j.jid.2023.03.1682

DO - 10.1016/j.jid.2023.03.1682

M3 - Journal article

C2 - 37085040

AN - SCOPUS:85162890838

VL - 143

SP - 2030

EP - 2038

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 10

ER -

ID: 359240353

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