Ansatte ved Biomedicinsk Institut – Københavns Universitet

Rat retinal vasomotion assessed by laser speckle imaging

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Dokumenter

Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

OriginalsprogEngelsk
Artikelnummere0173805
TidsskriftPloS one
Vol/bind12
Tidsskriftsnummer3
Antal sider13
ISSN1932-6203
DOI
StatusUdgivet - 2017

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