PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

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PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. / Blond, Martin Baeek; Schnurr, Theresia Maria; Rasenkilde, Mads; Quist, Jonas Sailing; Gram, Anne Sofie; Reichkendler, Michala Holm; Auerbach, Pernille Landrock; Nordby, Pernille; Skovgaard, Lene Theil; Ribel-Madsen, Rasmus; Justesen, Johann Marie; Kilpelainen, Tuomas Oskari; Ploug, Thorkil; Stallknecht, Bente Merete; Hansen, Torben.

I: Physiological Genomics, Bind 51, Nr. 6, 2019, s. 254-260.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Blond, MB, Schnurr, TM, Rasenkilde, M, Quist, JS, Gram, AS, Reichkendler, MH, Auerbach, PL, Nordby, P, Skovgaard, LT, Ribel-Madsen, R, Justesen, JM, Kilpelainen, TO, Ploug, T, Stallknecht, BM & Hansen, T 2019, 'PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training', Physiological Genomics, bind 51, nr. 6, s. 254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

APA

Blond, M. B., Schnurr, T. M., Rasenkilde, M., Quist, J. S., Gram, A. S., Reichkendler, M. H., ... Hansen, T. (2019). PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. Physiological Genomics, 51(6), 254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

Vancouver

Blond MB, Schnurr TM, Rasenkilde M, Quist JS, Gram AS, Reichkendler MH o.a. PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. Physiological Genomics. 2019;51(6):254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

Author

Blond, Martin Baeek ; Schnurr, Theresia Maria ; Rasenkilde, Mads ; Quist, Jonas Sailing ; Gram, Anne Sofie ; Reichkendler, Michala Holm ; Auerbach, Pernille Landrock ; Nordby, Pernille ; Skovgaard, Lene Theil ; Ribel-Madsen, Rasmus ; Justesen, Johann Marie ; Kilpelainen, Tuomas Oskari ; Ploug, Thorkil ; Stallknecht, Bente Merete ; Hansen, Torben. / PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. I: Physiological Genomics. 2019 ; Bind 51, Nr. 6. s. 254-260.

Bibtex

@article{f0d43dc7bb8e41f0a80ebdf42c068d32,
title = "PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training",
abstract = "The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95{\%} confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.",
keywords = "exercise, insulin sensitivity, intervention, PPARG, Pro12Ala",
author = "Blond, {Martin Baeek} and Schnurr, {Theresia Maria} and Mads Rasenkilde and Quist, {Jonas Sailing} and Gram, {Anne Sofie} and Reichkendler, {Michala Holm} and Auerbach, {Pernille Landrock} and Pernille Nordby and Skovgaard, {Lene Theil} and Rasmus Ribel-Madsen and Justesen, {Johann Marie} and Kilpelainen, {Tuomas Oskari} and Thorkil Ploug and Stallknecht, {Bente Merete} and Torben Hansen",
year = "2019",
doi = "10.1152/physiolgenomics.00101.2018",
language = "English",
volume = "51",
pages = "254--260",
journal = "Physiological Genomics",
issn = "1094-8341",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

AU - Blond, Martin Baeek

AU - Schnurr, Theresia Maria

AU - Rasenkilde, Mads

AU - Quist, Jonas Sailing

AU - Gram, Anne Sofie

AU - Reichkendler, Michala Holm

AU - Auerbach, Pernille Landrock

AU - Nordby, Pernille

AU - Skovgaard, Lene Theil

AU - Ribel-Madsen, Rasmus

AU - Justesen, Johann Marie

AU - Kilpelainen, Tuomas Oskari

AU - Ploug, Thorkil

AU - Stallknecht, Bente Merete

AU - Hansen, Torben

PY - 2019

Y1 - 2019

N2 - The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.

AB - The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.

KW - exercise

KW - insulin sensitivity

KW - intervention

KW - PPARG

KW - Pro12Ala

U2 - 10.1152/physiolgenomics.00101.2018

DO - 10.1152/physiolgenomics.00101.2018

M3 - Journal article

C2 - 31074700

VL - 51

SP - 254

EP - 260

JO - Physiological Genomics

JF - Physiological Genomics

SN - 1094-8341

IS - 6

ER -

ID: 223871442