Potassium channels in the heart

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Standard

Potassium channels in the heart. / Thomsen, Morten Bækgaard.

Channelopathies in Heart Disease. red. / Dierk Thomas ; Carol Ann Remme. Springer, 2018. s. 47-75 (Cardiac and Vascular Biology).

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Harvard

Thomsen, MB 2018, Potassium channels in the heart. i D Thomas & CA Remme (red), Channelopathies in Heart Disease. Springer, Cardiac and Vascular Biology, s. 47-75 . https://doi.org/10.1007/978-3-319-77812-9_3

APA

Thomsen, M. B. (2018). Potassium channels in the heart. I D. Thomas , & C. A. Remme (red.), Channelopathies in Heart Disease (s. 47-75 ). Springer. Cardiac and Vascular Biology https://doi.org/10.1007/978-3-319-77812-9_3

Vancouver

Thomsen MB. Potassium channels in the heart. I Thomas D, Remme CA, red., Channelopathies in Heart Disease. Springer. 2018. s. 47-75 . (Cardiac and Vascular Biology). https://doi.org/10.1007/978-3-319-77812-9_3

Author

Thomsen, Morten Bækgaard. / Potassium channels in the heart. Channelopathies in Heart Disease. red. / Dierk Thomas ; Carol Ann Remme. Springer, 2018. s. 47-75 (Cardiac and Vascular Biology).

Bibtex

@inbook{70535519f44046c5a421f2d44d262eee,
title = "Potassium channels in the heart",
abstract = "Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or K-Ca(2)), inwardly rectifying potassium channels (K-ir), two-pore-domain potassium channels (K-2P), and voltage-gated potassium channels (K-V). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.",
author = "Thomsen, {Morten B{\ae}kgaard}",
year = "2018",
doi = "10.1007/978-3-319-77812-9_3",
language = "English",
isbn = "978-3-319-77811-2",
series = "Cardiac and Vascular Biology",
publisher = "Springer",
pages = "47--75",
editor = "{Thomas }, {Dierk } and Remme, {Carol Ann }",
booktitle = "Channelopathies in Heart Disease",

}

RIS

TY - CHAP

T1 - Potassium channels in the heart

AU - Thomsen, Morten Bækgaard

PY - 2018

Y1 - 2018

N2 - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or K-Ca(2)), inwardly rectifying potassium channels (K-ir), two-pore-domain potassium channels (K-2P), and voltage-gated potassium channels (K-V). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

AB - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or K-Ca(2)), inwardly rectifying potassium channels (K-ir), two-pore-domain potassium channels (K-2P), and voltage-gated potassium channels (K-V). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

U2 - 10.1007/978-3-319-77812-9_3

DO - 10.1007/978-3-319-77812-9_3

M3 - Book chapter

SN - 978-3-319-77811-2

T3 - Cardiac and Vascular Biology

SP - 47

EP - 75

BT - Channelopathies in Heart Disease

A2 - Thomas , Dierk

A2 - Remme, Carol Ann

PB - Springer

ER -

ID: 210151234