Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects. / Prahm, August Pilegaard; Hvistendahl, Mark Krogh; Brandt, Christopher Filtenborg; Blanche, Paul; Hartmann, Bolette; Holst, Jens Juul; Jeppesen, Palle Bekker.

I: Peptides, Bind 169, 171091, 2023.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Prahm, AP, Hvistendahl, MK, Brandt, CF, Blanche, P, Hartmann, B, Holst, JJ & Jeppesen, PB 2023, 'Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects', Peptides, bind 169, 171091. https://doi.org/10.1016/j.peptides.2023.171091

APA

Prahm, A. P., Hvistendahl, M. K., Brandt, C. F., Blanche, P., Hartmann, B., Holst, J. J., & Jeppesen, P. B. (2023). Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects. Peptides, 169, [171091]. https://doi.org/10.1016/j.peptides.2023.171091

Vancouver

Prahm AP, Hvistendahl MK, Brandt CF, Blanche P, Hartmann B, Holst JJ o.a. Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects. Peptides. 2023;169. 171091. https://doi.org/10.1016/j.peptides.2023.171091

Author

Prahm, August Pilegaard ; Hvistendahl, Mark Krogh ; Brandt, Christopher Filtenborg ; Blanche, Paul ; Hartmann, Bolette ; Holst, Jens Juul ; Jeppesen, Palle Bekker. / Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects. I: Peptides. 2023 ; Bind 169.

Bibtex

@article{1e63651fe6b64d74adc8878bde10f120,
title = "Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects",
abstract = "Glucagon-like peptide 2 (GLP-2) is an important regulator of intestinal growth and function. In adherable mixed meals the macronutrient composition with the best potential for stimulating GLP-2 secretion is not known. We compared the effect of 3 iso-energetic meals, where approximately 60 % of the energy ratio was provided as either carbohydrate, fat, or protein, respectively, on the post-prandial endogenous GLP-2 secretion. The responses were compared to secretion profiles of peptide YY (PYY), and glucose-dependent insulinotropic peptide (GIP). Ten healthy subjects were admitted on three occasions, at least a week apart, after a night of fasting. In an open-label, crossover design, they were randomized to receive a high carbohydrate (HC), high fat (HF) or high protein (HP) meal. The meals were approximately ∼3.9 MJ. Venous blood was collected for 240 min, and plasma concentrations of GLP-2, GIP and PYY were measured with specific radioimmunoassays. Mean GLP-2 levels peaked already at 30 min for the HC meal, however the HP meal induced the highest mean GLP-2 peaking levels, resulting in significantly higher mean GLP-2 area under the curve (AUC) from baseline of 7279 pmol*min/L, 95 %-CI [6081;8477] compared to the HC meal: 4764 pmol*min/L, 95 %-CI [3498;6029], p = 0.020 and the HF meal: 4796 pmol*min/L, [3385;6207], p = 0.011. Findings were similar for the PYY. The HC meal provided a greater AUC for GIP compared to the HP- and HF meals. The HP meal was most effective with respect to stimulation of the postprandial GLP-2 and PYY secretion, whereas the HC meal was more effective for GIP.",
keywords = "Glucagon-like peptide 2, Glucose-dependent insulinotropic polypeptide, Peptide YY, Post-prandial secretion",
author = "Prahm, {August Pilegaard} and Hvistendahl, {Mark Krogh} and Brandt, {Christopher Filtenborg} and Paul Blanche and Bolette Hartmann and Holst, {Jens Juul} and Jeppesen, {Palle Bekker}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.peptides.2023.171091",
language = "English",
volume = "169",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects

AU - Prahm, August Pilegaard

AU - Hvistendahl, Mark Krogh

AU - Brandt, Christopher Filtenborg

AU - Blanche, Paul

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Jeppesen, Palle Bekker

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Glucagon-like peptide 2 (GLP-2) is an important regulator of intestinal growth and function. In adherable mixed meals the macronutrient composition with the best potential for stimulating GLP-2 secretion is not known. We compared the effect of 3 iso-energetic meals, where approximately 60 % of the energy ratio was provided as either carbohydrate, fat, or protein, respectively, on the post-prandial endogenous GLP-2 secretion. The responses were compared to secretion profiles of peptide YY (PYY), and glucose-dependent insulinotropic peptide (GIP). Ten healthy subjects were admitted on three occasions, at least a week apart, after a night of fasting. In an open-label, crossover design, they were randomized to receive a high carbohydrate (HC), high fat (HF) or high protein (HP) meal. The meals were approximately ∼3.9 MJ. Venous blood was collected for 240 min, and plasma concentrations of GLP-2, GIP and PYY were measured with specific radioimmunoassays. Mean GLP-2 levels peaked already at 30 min for the HC meal, however the HP meal induced the highest mean GLP-2 peaking levels, resulting in significantly higher mean GLP-2 area under the curve (AUC) from baseline of 7279 pmol*min/L, 95 %-CI [6081;8477] compared to the HC meal: 4764 pmol*min/L, 95 %-CI [3498;6029], p = 0.020 and the HF meal: 4796 pmol*min/L, [3385;6207], p = 0.011. Findings were similar for the PYY. The HC meal provided a greater AUC for GIP compared to the HP- and HF meals. The HP meal was most effective with respect to stimulation of the postprandial GLP-2 and PYY secretion, whereas the HC meal was more effective for GIP.

AB - Glucagon-like peptide 2 (GLP-2) is an important regulator of intestinal growth and function. In adherable mixed meals the macronutrient composition with the best potential for stimulating GLP-2 secretion is not known. We compared the effect of 3 iso-energetic meals, where approximately 60 % of the energy ratio was provided as either carbohydrate, fat, or protein, respectively, on the post-prandial endogenous GLP-2 secretion. The responses were compared to secretion profiles of peptide YY (PYY), and glucose-dependent insulinotropic peptide (GIP). Ten healthy subjects were admitted on three occasions, at least a week apart, after a night of fasting. In an open-label, crossover design, they were randomized to receive a high carbohydrate (HC), high fat (HF) or high protein (HP) meal. The meals were approximately ∼3.9 MJ. Venous blood was collected for 240 min, and plasma concentrations of GLP-2, GIP and PYY were measured with specific radioimmunoassays. Mean GLP-2 levels peaked already at 30 min for the HC meal, however the HP meal induced the highest mean GLP-2 peaking levels, resulting in significantly higher mean GLP-2 area under the curve (AUC) from baseline of 7279 pmol*min/L, 95 %-CI [6081;8477] compared to the HC meal: 4764 pmol*min/L, 95 %-CI [3498;6029], p = 0.020 and the HF meal: 4796 pmol*min/L, [3385;6207], p = 0.011. Findings were similar for the PYY. The HC meal provided a greater AUC for GIP compared to the HP- and HF meals. The HP meal was most effective with respect to stimulation of the postprandial GLP-2 and PYY secretion, whereas the HC meal was more effective for GIP.

KW - Glucagon-like peptide 2

KW - Glucose-dependent insulinotropic polypeptide

KW - Peptide YY

KW - Post-prandial secretion

UR - http://www.scopus.com/inward/record.url?scp=85171649598&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2023.171091

DO - 10.1016/j.peptides.2023.171091

M3 - Journal article

C2 - 37640265

AN - SCOPUS:85171649598

VL - 169

JO - Peptides

JF - Peptides

SN - 0196-9781

M1 - 171091

ER -

ID: 369123484