Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease

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Standard

Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease. / Tran, Cao Thach; Atanasovska, Tania; Graff, Claus; Melgaard, Jacob; Kanters, Jørgen K.; Smith, Robert; Petersen, Aaron C.; Kjeldsen, Keld P.; McKenna, Michael J.

I: European Journal of Applied Physiology, Bind 122, 2022, s. 691–702.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tran, CT, Atanasovska, T, Graff, C, Melgaard, J, Kanters, JK, Smith, R, Petersen, AC, Kjeldsen, KP & McKenna, MJ 2022, 'Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease', European Journal of Applied Physiology, bind 122, s. 691–702. https://doi.org/10.1007/s00421-021-04870-7

APA

Tran, C. T., Atanasovska, T., Graff, C., Melgaard, J., Kanters, J. K., Smith, R., Petersen, A. C., Kjeldsen, K. P., & McKenna, M. J. (2022). Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease. European Journal of Applied Physiology, 122, 691–702. https://doi.org/10.1007/s00421-021-04870-7

Vancouver

Tran CT, Atanasovska T, Graff C, Melgaard J, Kanters JK, Smith R o.a. Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease. European Journal of Applied Physiology. 2022;122:691–702. https://doi.org/10.1007/s00421-021-04870-7

Author

Tran, Cao Thach ; Atanasovska, Tania ; Graff, Claus ; Melgaard, Jacob ; Kanters, Jørgen K. ; Smith, Robert ; Petersen, Aaron C. ; Kjeldsen, Keld P. ; McKenna, Michael J. / Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease. I: European Journal of Applied Physiology. 2022 ; Bind 122. s. 691–702.

Bibtex

@article{98a88677a392498f955c73352a1c14e9,
title = "Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease",
abstract = "Purpose: The cardiac T-wave peak-to-end interval (Tpe) is thought to reflect dispersion in ventricular repolarisation, with abnormalities in Tpe associated with increased risk of arrhythmia. Extracellular K+ modulates cardiac repolarisation, and since arterial plasma K+ concentration ([K+]) rapidly increases during and declines following exercise, we investigated the relationship between [K+] and Tpe with exercise. Methods: Serial ECGs (Tpe, Tpe/QT ratio) and [K+] were obtained from 8 healthy, normokalaemic volunteers and 22 patients with end-stage renal disease (ESRD), at rest, during, and after exhaustive exercise. Results: Post-exercise [K+] nadir was 3.1 ± 0.1, 5.0 ± 0.2 and 4.0 ± 0.1 mmol.L−1 (mean ± SEM) for healthy participants and ESRD patients before and after haemodialysis, respectively. In healthy participants, compared to pre-exercise, recovery-induced low [K+] was associated with a prolongation of Tpe (110 ± 8 vs. 87 ± 5 ms, respectively, p = 0.03) and an increase in Tpe/QT ratio (0.28 ± 0.01 vs. 0.23 ± 0.01, respectively, p = 0.01). Analyses of serial data revealed [K+] as a predictor of Tpe in healthy participants (β = -0.54 ±0.05, p < 0.0001), in ESRD patients (β = -0.75 ± 0.06, p < 0.0001) and for all data pooled (β = -0.61 ± 0.04, p < 0.0001). The [K+] was also a predictor of Tpe/QT ratio in healthy participants and ESRD patients. Conclusions: Tpe and Tpe/QT ratio are predicted by [K+] during exercise. Low [K+] during recovery from exercise was associated with increased Tpe and Tpe/QT, indicating accentuated dispersion of ventricular repolarisation. The findings suggest that variations in [K+] with physical exertion may unmask electrophysiological vulnerabilities to arrhythmia.",
keywords = "Arrhythmia, ECG, Exercise, Hyperkalaemia, Hypokalaemia, Potassium, QT, Sudden cardiac death, Tpeak–Tend",
author = "Tran, {Cao Thach} and Tania Atanasovska and Claus Graff and Jacob Melgaard and Kanters, {J{\o}rgen K.} and Robert Smith and Petersen, {Aaron C.} and Kjeldsen, {Keld P.} and McKenna, {Michael J.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2022",
doi = "10.1007/s00421-021-04870-7",
language = "English",
volume = "122",
pages = "691–702",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Plasma potassium concentration and cardiac repolarisation markers, Tpeak–Tend and Tpeak–Tend/QT, during and after exercise in healthy participants and in end-stage renal disease

AU - Tran, Cao Thach

AU - Atanasovska, Tania

AU - Graff, Claus

AU - Melgaard, Jacob

AU - Kanters, Jørgen K.

AU - Smith, Robert

AU - Petersen, Aaron C.

AU - Kjeldsen, Keld P.

AU - McKenna, Michael J.

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022

Y1 - 2022

N2 - Purpose: The cardiac T-wave peak-to-end interval (Tpe) is thought to reflect dispersion in ventricular repolarisation, with abnormalities in Tpe associated with increased risk of arrhythmia. Extracellular K+ modulates cardiac repolarisation, and since arterial plasma K+ concentration ([K+]) rapidly increases during and declines following exercise, we investigated the relationship between [K+] and Tpe with exercise. Methods: Serial ECGs (Tpe, Tpe/QT ratio) and [K+] were obtained from 8 healthy, normokalaemic volunteers and 22 patients with end-stage renal disease (ESRD), at rest, during, and after exhaustive exercise. Results: Post-exercise [K+] nadir was 3.1 ± 0.1, 5.0 ± 0.2 and 4.0 ± 0.1 mmol.L−1 (mean ± SEM) for healthy participants and ESRD patients before and after haemodialysis, respectively. In healthy participants, compared to pre-exercise, recovery-induced low [K+] was associated with a prolongation of Tpe (110 ± 8 vs. 87 ± 5 ms, respectively, p = 0.03) and an increase in Tpe/QT ratio (0.28 ± 0.01 vs. 0.23 ± 0.01, respectively, p = 0.01). Analyses of serial data revealed [K+] as a predictor of Tpe in healthy participants (β = -0.54 ±0.05, p < 0.0001), in ESRD patients (β = -0.75 ± 0.06, p < 0.0001) and for all data pooled (β = -0.61 ± 0.04, p < 0.0001). The [K+] was also a predictor of Tpe/QT ratio in healthy participants and ESRD patients. Conclusions: Tpe and Tpe/QT ratio are predicted by [K+] during exercise. Low [K+] during recovery from exercise was associated with increased Tpe and Tpe/QT, indicating accentuated dispersion of ventricular repolarisation. The findings suggest that variations in [K+] with physical exertion may unmask electrophysiological vulnerabilities to arrhythmia.

AB - Purpose: The cardiac T-wave peak-to-end interval (Tpe) is thought to reflect dispersion in ventricular repolarisation, with abnormalities in Tpe associated with increased risk of arrhythmia. Extracellular K+ modulates cardiac repolarisation, and since arterial plasma K+ concentration ([K+]) rapidly increases during and declines following exercise, we investigated the relationship between [K+] and Tpe with exercise. Methods: Serial ECGs (Tpe, Tpe/QT ratio) and [K+] were obtained from 8 healthy, normokalaemic volunteers and 22 patients with end-stage renal disease (ESRD), at rest, during, and after exhaustive exercise. Results: Post-exercise [K+] nadir was 3.1 ± 0.1, 5.0 ± 0.2 and 4.0 ± 0.1 mmol.L−1 (mean ± SEM) for healthy participants and ESRD patients before and after haemodialysis, respectively. In healthy participants, compared to pre-exercise, recovery-induced low [K+] was associated with a prolongation of Tpe (110 ± 8 vs. 87 ± 5 ms, respectively, p = 0.03) and an increase in Tpe/QT ratio (0.28 ± 0.01 vs. 0.23 ± 0.01, respectively, p = 0.01). Analyses of serial data revealed [K+] as a predictor of Tpe in healthy participants (β = -0.54 ±0.05, p < 0.0001), in ESRD patients (β = -0.75 ± 0.06, p < 0.0001) and for all data pooled (β = -0.61 ± 0.04, p < 0.0001). The [K+] was also a predictor of Tpe/QT ratio in healthy participants and ESRD patients. Conclusions: Tpe and Tpe/QT ratio are predicted by [K+] during exercise. Low [K+] during recovery from exercise was associated with increased Tpe and Tpe/QT, indicating accentuated dispersion of ventricular repolarisation. The findings suggest that variations in [K+] with physical exertion may unmask electrophysiological vulnerabilities to arrhythmia.

KW - Arrhythmia

KW - ECG

KW - Exercise

KW - Hyperkalaemia

KW - Hypokalaemia

KW - Potassium

KW - QT

KW - Sudden cardiac death

KW - Tpeak–Tend

U2 - 10.1007/s00421-021-04870-7

DO - 10.1007/s00421-021-04870-7

M3 - Journal article

C2 - 35048183

AN - SCOPUS:85122997455

VL - 122

SP - 691

EP - 702

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

ER -

ID: 291226635