Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
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Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside. / Midtkandal, Rebecca R.; Redpath, Philip; Trammell, Samuel A J; MacDonald, Simon J F; Brenner, Charles; Migaud, Marie E.
I: Bioorganic and Medicinal Chemistry Letters, Bind 22, Nr. 16, 15.08.2012, s. 5204-5207.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
AU - Midtkandal, Rebecca R.
AU - Redpath, Philip
AU - Trammell, Samuel A J
AU - MacDonald, Simon J F
AU - Brenner, Charles
AU - Migaud, Marie E.
PY - 2012/8/15
Y1 - 2012/8/15
N2 - 2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed.
AB - 2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed.
KW - Benzamide riboside
KW - C-Nucleoside
KW - Inosine monophosphate dehydrogenase
KW - Intramolecular cyclisation
KW - Nicotinamide adenine dinucleotide
UR - http://www.scopus.com/inward/record.url?scp=84864411406&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2012.06.069
DO - 10.1016/j.bmcl.2012.06.069
M3 - Journal article
C2 - 22795628
AN - SCOPUS:84864411406
VL - 22
SP - 5204
EP - 5207
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
SN - 0960-894X
IS - 16
ER -
ID: 220855816