Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt


  • Fulltext

    Forlagets udgivne version, 2,58 MB, PDF-dokument

  • Sobuj Mia
  • Ravi Sonkar
  • Lamario Williams
  • Mary N. Latimer
  • David R. Rawnsley
  • Samir Rana
  • Jin He
  • Pieterjan Dierickx
  • Teayoun Kim
  • Min Xie
  • Kirk M. Habegger
  • Masato Kubo
  • Lufang Zhou
  • Thomsen, Morten Bækgaard
  • Sumanth D. Prabhu
  • Stuart J. Frank
  • Paul S. Brookes
  • Mitchell A. Lazar
  • Abhinav Diwan
  • Martin E. Young

Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that, disruption of the clock leads to age-onset cardiomyopathy (through unknown mechanisms). Here, we report that genetic disruption of the cardiomyocyte clock results in chronic induction of the transcriptional repressor E4BP4. Importantly, E4BP4 deletion prevents age-onset cardiomyopathy following clock disruption. These studies also indicate that E4BP4 regulates both cardiac metabolism (eg, fatty acid oxidation) and electrophysiology (eg, QT interval). Collectively, these studies reveal that E4BP4 is a novel regulator of both cardiac physiology and pathophysiology.

TidsskriftJACC: Basic to Translational Science
Udgave nummer9
Sider (fra-til)1141-1156
Antal sider16
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
The authors would like to thank Maximiliano Grenett and Jun Cheng for technical assistance.

Publisher Copyright:
© 2023 The Authors

ID: 369136941