Standard
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study. / Johnson, Emma C.; Bjelland, Douglas W.; Howrigan, Daniel P; Abdellaoui, Abdel; Breen, Gerome; Borglum, Anders D.; Cichon, Sven; Degenhardt, Franziska; Forstner, Andreas J; Frank, Josef; Genovese, Giulio; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffman, Per; Maier, Wolfgang; Mattheisen, Manuel; Morris, Derek W; Mowry, Bryan J; Müller-Mhysok, Betram; Neale, Benjamin M; Nenadic, Igor; Nöthen, Markus M; O’Dushlaine, Colm; Rietschel, Marcella; Ruderfer, Douglas M; Rujescu, Dan; Schulze, Thomas G; Simonson, Matthew A; Stahl, Eli A; Strohmaier, Jana; Witt, Stephanie H.; Ripke, Stephan; Neale, Benjamin M; Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A; Lee, Phil H; Bulik-Sullivan, Brendan; Collier, David A; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu-Alin; Begemann, Martin; Belliveau, Richard A.; Bene, Judit; Bergen, Sarah E; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W; Bruggeman, Richard; Buccola, Nancy G; Buckner, Randy L.; Byerley, William F; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M; Carr, Vaughan J; Carrera, Noa; Catts, Stanley V; Chambert, Kimberly D.; Chan, Raymond C.K.; Chen, Ronald Y.L.; Chen, Eric Y H; Cheng, Wei; Cheung, Eric F.C.; Chong, Siow Ann; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Del-Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H; Farrell, Martilias S.; Franke, Lude; Freedman, Robert; Freimer, Nelson B; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M; Henskens, Frans A; Hirschhorn, Joel N; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Kucinskiene, Zita Ausrele; Kuzelova-Ptackova, Hana; Kähler, Anna K; Laurent, Claudine; Chee Keong, Jimmy Lee; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M; Lubinski, Jan; Lönnqvist, Jouko; Macek, Milan; Magnusson, Patrik K E; Maher, Brion S; Mallet, Jacques; Marsal, Sara; Mattingsdal, Morten; McCarley, Robert W; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra M; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W; Mors, Ole; Murphy, Kieran C; Murray, Robin M; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nertney, Deborah A; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm T; Anthony O'Neill, F.; Oh, Sang Yun; Olincy, Ann; Olsen, Line; van Os, Jim; Pantelis, Christos; Papadimitriou, George N; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes L; Pulver, Ann E; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L; Roussos, Panos; Salomaa, Veikko; Sanders, Alan R; Schall, Ulrich; Schubert, Christian R.; Schwab, Sibylle G; Scolnick, Edward M.; Scott, Rodney J; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon Cheong; Spencer, Chris C A; Stahl, Eli A; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B; Williams, Nigel M; Watts-Williams, Stephanie J.; Wolen, Aaron R.; Wong, Emily H.M.; Wormley, Brandon K.; Xi, Hualin Simon; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R; Stefansson, Kari; Visscher, Peter M; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H R; Bramon, Elvira; Buxbaum, Joseph D; Børglum, Anders D; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V; Gill, Michael; Gurling, Hugh; Hultman, Christina M; Iwata, Nakao; Jablensky, Assen V; Jönsson, Erik G; Kendler, Kenneth S; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K; McCarroll, Steven A; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B; Mowry, Bryan J; Nöthen, Markus M; Ophoff, Roel A; Owen, Michael J; Palotie, Aarno; Pato, Carlos N; Petryshen, Tracey L.; Posthuma, Danielle; Riley, Brien P; Sham, Pak-Chung; Sklar, Pamela; St Clair, David; Weinberger, Daniel R; Wendland, Jens R.; Werge, Thomas; Daly, Mark J; O'Donovan, Michael C; Sullivan, Patrick F; Keller, Matthew C.
I:
PLOS Genetics, Bind 12, Nr. 10, e1006343, 10.2016.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Johnson, EC, Bjelland, DW, Howrigan, DP, Abdellaoui, A, Breen, G, Borglum, AD, Cichon, S, Degenhardt, F, Forstner, AJ, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, DW, Mowry, BJ, Müller-Mhysok, B, Neale, BM, Nenadic, I, Nöthen, MM, O’Dushlaine, C, Rietschel, M, Ruderfer, DM, Rujescu, D, Schulze, TG, Simonson, MA, Stahl, EA, Strohmaier, J, Witt, SH, Ripke, S, Neale, BM, Corvin, A, Walters, JTR, Farh, K-H, Holmans, PA, Lee, PH, Bulik-Sullivan, B, Collier, DA, Huang, H
, Pers, TH, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S-A, Begemann, M, Belliveau, RA, Bene, J, Bergen, SE, Bevilacqua, E, Bigdeli, TB, Black, DW, Bruggeman, R, Buccola, NG, Buckner, RL, Byerley, WF, Cahn, W, Cai, G, Campion, D, Cantor, RM, Carr, VJ, Carrera, N, Catts, SV, Chambert, KD, Chan, RCK, Chen, RYL, Chen, EYH, Cheng, W, Cheung, EFC, Chong, SA, Robert Cloninger, C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, JJ, Curtis, D, Davidson, M, Davis, KL, Del-Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, AH, Farrell, MS, Franke, L, Freedman, R, Freimer, NB, Friedl, M, Friedman, JI, Fromer, M, Georgieva, L, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, JI, Golimbet, V, Gopal, S, Gratten, J, de Haan, L, Hammer, C, Hamshere, ML, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, AM, Henskens, FA, Hirschhorn, JN, Hoffmann, P, Hofman, A, Hollegaard, MV, Hougaard, DM, Ikeda, M, Joa, I, Julià, A, Kahn, RS, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Kennedy, JL, Khrunin, A, Kim, Y, Klovins, J, Knowles, JA, Konte, B, Kucinskas, V, Kucinskiene, ZA, Kuzelova-Ptackova, H, Kähler, AK, Laurent, C, Chee Keong, JL, Hong Lee, S, Legge, SE, Lerer, B, Li, M, Li, T, Liang, K-Y, Lieberman, J, Limborska, S, Loughland, CM, Lubinski, J, Lönnqvist, J, Macek, M, Magnusson, PKE, Maher, BS, Mallet, J, Marsal, S, Mattingsdal, M, McCarley, RW, McDonald, C, McIntosh, AM, Meier, SM, Meijer, CJ, Melegh, B, Melle, I, Mesholam-Gately, RI, Metspalu, A, Michie, PT, Milani, L, Milanova, V, Mokrab, Y, Morris, DW, Mors, O, Murphy, KC, Murray, RM, Myin-Germeys, I, Müller-Myhsok, B, Nelis, M, Nertney, DA, Nestadt, G, Nicodemus, KK, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, CT, Anthony O'Neill, F, Oh, SY, Olincy, A, Olsen, L, van Os, J, Pantelis, C, Papadimitriou, GN, Papiol, S, Parkhomenko, E, Pato, MT, Paunio, T, Pejovic-Milovancevic, M, Perkins, DO, Pietiläinen, O, Pimm, J, Pocklington, AJ, Powell, J, Price, AL, Pulver, AE, Purcell, SM, Quested, D
, Rasmussen, HB, Reichenberg, A, Reimers, MA, Richards, AL, Roffman, JL, Roussos, P, Salomaa, V, Sanders, AR, Schall, U, Schubert, CR, Schwab, SG, Scolnick, EM, Scott, RJ, Seidman, LJ, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, JM, Sim, K, Slominsky, P, Smoller, JW, So, HC, Spencer, CCA, Stahl, EA, Stefansson, H, Steinberg, S, Stogmann, E, Straub, RE, Strengman, E, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, DM, Szatkiewicz, JP, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, BT, Weiser, M, Wildenauer, DB, Williams, NM, Watts-Williams, SJ, Wolen, AR, Wong, EHM, Wormley, BK, Xi, HS, Zai, CC, Zheng, X, Zimprich, F, Wray, NR, Stefansson, K, Visscher, PM, Adolfsson, R, Andreassen, OA, Blackwood, DHR, Bramon, E, Buxbaum, JD, Børglum, AD, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, PV, Gill, M, Gurling, H, Hultman, CM, Iwata, N, Jablensky, AV, Jönsson, EG, Kendler, KS, Kirov, G, Knight, J, Lencz, T, Levinson, DF, Li, QS, Liu, J, Malhotra, AK, McCarroll, SA, McQuillin, A, Moran, JL, Mortensen, PB, Mowry, BJ, Nöthen, MM, Ophoff, RA, Owen, MJ, Palotie, A, Pato, CN, Petryshen, TL, Posthuma, D, Riley, BP, Sham, P-C, Sklar, P, St Clair, D, Weinberger, DR, Wendland, JR
, Werge, T, Daly, MJ, O'Donovan, MC, Sullivan, PF & Keller, MC 2016, '
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study',
PLOS Genetics, bind 12, nr. 10, e1006343.
https://doi.org/10.1371/journal.pgen.1006343APA
Johnson, E. C., Bjelland, D. W., Howrigan, D. P., Abdellaoui, A., Breen, G., Borglum, A. D., Cichon, S., Degenhardt, F., Forstner, A. J., Frank, J., Genovese, G., Heilmann-Heimbach, S., Herms, S., Hoffman, P., Maier, W., Mattheisen, M., Morris, D. W., Mowry, B. J., Müller-Mhysok, B., ... Keller, M. C. (2016).
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
PLOS Genetics,
12(10), [e1006343].
https://doi.org/10.1371/journal.pgen.1006343Vancouver
Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Breen G, Borglum AD o.a.
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
PLOS Genetics. 2016 okt.;12(10). e1006343.
https://doi.org/10.1371/journal.pgen.1006343Author
Johnson, Emma C. ; Bjelland, Douglas W. ; Howrigan, Daniel P ; Abdellaoui, Abdel ; Breen, Gerome ; Borglum, Anders D. ; Cichon, Sven ; Degenhardt, Franziska ; Forstner, Andreas J ; Frank, Josef ; Genovese, Giulio ; Heilmann-Heimbach, Stefanie ; Herms, Stefan ; Hoffman, Per ; Maier, Wolfgang ; Mattheisen, Manuel ; Morris, Derek W ; Mowry, Bryan J ; Müller-Mhysok, Betram ; Neale, Benjamin M ; Nenadic, Igor ; Nöthen, Markus M ; O’Dushlaine, Colm ; Rietschel, Marcella ; Ruderfer, Douglas M ; Rujescu, Dan ; Schulze, Thomas G ; Simonson, Matthew A ; Stahl, Eli A ; Strohmaier, Jana ; Witt, Stephanie H. ; Ripke, Stephan ; Neale, Benjamin M ; Corvin, Aiden ; Walters, James T. R. ; Farh, Kai-How ; Holmans, Peter A ; Lee, Phil H ; Bulik-Sullivan, Brendan ; Collier, David A ; Huang, Hailiang ; Pers, Tune H. ; Agartz, Ingrid ; Agerbo, Esben ; Albus, Margot ; Alexander, Madeline ; Amin, Farooq ; Bacanu, Silviu-Alin ; Begemann, Martin ; Belliveau, Richard A. ; Bene, Judit ; Bergen, Sarah E ; Bevilacqua, Elizabeth ; Bigdeli, Tim B. ; Black, Donald W ; Bruggeman, Richard ; Buccola, Nancy G ; Buckner, Randy L. ; Byerley, William F ; Cahn, Wiepke ; Cai, Guiqing ; Campion, Dominique ; Cantor, Rita M ; Carr, Vaughan J ; Carrera, Noa ; Catts, Stanley V ; Chambert, Kimberly D. ; Chan, Raymond C.K. ; Chen, Ronald Y.L. ; Chen, Eric Y H ; Cheng, Wei ; Cheung, Eric F.C. ; Chong, Siow Ann ; Robert Cloninger, C. ; Cohen, David ; Cohen, Nadine ; Cormican, Paul ; Craddock, Nick ; Crowley, James J. ; Curtis, David ; Davidson, Michael ; Davis, Kenneth L. ; Del-Favero, Jurgen ; Demontis, Ditte ; Dikeos, Dimitris ; Dinan, Timothy ; Djurovic, Srdjan ; Donohoe, Gary ; Drapeau, Elodie ; Duan, Jubao ; Dudbridge, Frank ; Durmishi, Naser ; Eichhammer, Peter ; Eriksson, Johan ; Escott-Price, Valentina ; Essioux, Laurent ; Fanous, Ayman H ; Farrell, Martilias S. ; Franke, Lude ; Freedman, Robert ; Freimer, Nelson B ; Friedl, Marion ; Friedman, Joseph I. ; Fromer, Menachem ; Georgieva, Lyudmila ; Giegling, Ina ; Giusti-Rodríguez, Paola ; Godard, Stephanie ; Goldstein, Jacqueline I ; Golimbet, Vera ; Gopal, Srihari ; Gratten, Jacob ; de Haan, Lieuwe ; Hammer, Christian ; Hamshere, Marian L. ; Hansen, Mark ; Hansen, Thomas ; Haroutunian, Vahram ; Hartmann, Annette M ; Henskens, Frans A ; Hirschhorn, Joel N ; Hoffmann, Per ; Hofman, Andrea ; Hollegaard, Mads V ; Hougaard, David M. ; Ikeda, Masashi ; Joa, Inge ; Julià, Antonio ; Kahn, René S ; Kalaydjieva, Luba ; Karachanak-Yankova, Sena ; Karjalainen, Juha ; Kavanagh, David ; Kennedy, James L. ; Khrunin, Andrey ; Kim, Yunjung ; Klovins, Janis ; Knowles, James A. ; Konte, Bettina ; Kucinskas, Vaidutis ; Kucinskiene, Zita Ausrele ; Kuzelova-Ptackova, Hana ; Kähler, Anna K ; Laurent, Claudine ; Chee Keong, Jimmy Lee ; Hong Lee, S. ; Legge, Sophie E. ; Lerer, Bernard ; Li, Miaoxin ; Li, Tao ; Liang, Kung-Yee ; Lieberman, Jeffrey ; Limborska, Svetlana ; Loughland, Carmel M ; Lubinski, Jan ; Lönnqvist, Jouko ; Macek, Milan ; Magnusson, Patrik K E ; Maher, Brion S ; Mallet, Jacques ; Marsal, Sara ; Mattingsdal, Morten ; McCarley, Robert W ; McDonald, Colm ; McIntosh, Andrew M. ; Meier, Sandra M ; Meijer, Carin J. ; Melegh, Bela ; Melle, Ingrid ; Mesholam-Gately, Raquelle I. ; Metspalu, Andres ; Michie, Patricia T ; Milani, Lili ; Milanova, Vihra ; Mokrab, Younes ; Morris, Derek W ; Mors, Ole ; Murphy, Kieran C ; Murray, Robin M ; Myin-Germeys, Inez ; Müller-Myhsok, Bertram ; Nelis, Mari ; Nertney, Deborah A ; Nestadt, Gerald ; Nicodemus, Kristin K. ; Nikitina-Zake, Liene ; Nisenbaum, Laura ; Nordin, Annelie ; O'Callaghan, Eadbhard ; O'Dushlaine, Colm T ; Anthony O'Neill, F. ; Oh, Sang Yun ; Olincy, Ann ; Olsen, Line ; van Os, Jim ; Pantelis, Christos ; Papadimitriou, George N ; Papiol, Sergi ; Parkhomenko, Elena ; Pato, Michele T ; Paunio, Tiina ; Pejovic-Milovancevic, Milica ; Perkins, Diana O. ; Pietiläinen, Olli ; Pimm, Jonathan ; Pocklington, Andrew J. ; Powell, John ; Price, Alkes L ; Pulver, Ann E ; Purcell, Shaun M. ; Quested, Digby ; Rasmussen, Henrik B. ; Reichenberg, Abraham ; Reimers, Mark A. ; Richards, Alexander L. ; Roffman, Joshua L ; Roussos, Panos ; Salomaa, Veikko ; Sanders, Alan R ; Schall, Ulrich ; Schubert, Christian R. ; Schwab, Sibylle G ; Scolnick, Edward M. ; Scott, Rodney J ; Seidman, Larry J. ; Shi, Jianxin ; Sigurdsson, Engilbert ; Silagadze, Teimuraz ; Silverman, Jeremy M ; Sim, Kang ; Slominsky, Petr ; Smoller, Jordan W. ; So, Hon Cheong ; Spencer, Chris C A ; Stahl, Eli A ; Stefansson, Hreinn ; Steinberg, Stacy ; Stogmann, Elisabeth ; Straub, Richard E. ; Strengman, Eric ; Scott Stroup, T. ; Subramaniam, Mythily ; Suvisaari, Jaana ; Svrakic, Dragan M. ; Szatkiewicz, Jin P. ; Söderman, Erik ; Thirumalai, Srinivas ; Toncheva, Draga ; Tosato, Sarah ; Veijola, Juha ; Waddington, John ; Walsh, Dermot ; Wang, Dai ; Wang, Qiang ; Webb, Bradley T. ; Weiser, Mark ; Wildenauer, Dieter B ; Williams, Nigel M ; Watts-Williams, Stephanie J. ; Wolen, Aaron R. ; Wong, Emily H.M. ; Wormley, Brandon K. ; Xi, Hualin Simon ; Zai, Clement C. ; Zheng, Xuebin ; Zimprich, Fritz ; Wray, Naomi R ; Stefansson, Kari ; Visscher, Peter M ; Adolfsson, Rolf ; Andreassen, Ole A. ; Blackwood, Douglas H R ; Bramon, Elvira ; Buxbaum, Joseph D ; Børglum, Anders D ; Darvasi, Ariel ; Domenici, Enrico ; Ehrenreich, Hannelore ; Esko, Tõnu ; Gejman, Pablo V ; Gill, Michael ; Gurling, Hugh ; Hultman, Christina M ; Iwata, Nakao ; Jablensky, Assen V ; Jönsson, Erik G ; Kendler, Kenneth S ; Kirov, George ; Knight, Jo ; Lencz, Todd ; Levinson, Douglas F ; Li, Qingqin S. ; Liu, Jianjun ; Malhotra, Anil K ; McCarroll, Steven A ; McQuillin, Andrew ; Moran, Jennifer L. ; Mortensen, Preben B ; Mowry, Bryan J ; Nöthen, Markus M ; Ophoff, Roel A ; Owen, Michael J ; Palotie, Aarno ; Pato, Carlos N ; Petryshen, Tracey L. ; Posthuma, Danielle ; Riley, Brien P ; Sham, Pak-Chung ; Sklar, Pamela ; St Clair, David ; Weinberger, Daniel R ; Wendland, Jens R. ; Werge, Thomas ; Daly, Mark J ; O'Donovan, Michael C ; Sullivan, Patrick F ; Keller, Matthew C. / No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study. I: PLOS Genetics. 2016 ; Bind 12, Nr. 10.
Bibtex
@article{7730682e6ab1409e96eb51c7fdf2d1fe,
title = "No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study",
abstract = "It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.",
author = "Johnson, {Emma C.} and Bjelland, {Douglas W.} and Howrigan, {Daniel P} and Abdel Abdellaoui and Gerome Breen and Borglum, {Anders D.} and Sven Cichon and Franziska Degenhardt and Forstner, {Andreas J} and Josef Frank and Giulio Genovese and Stefanie Heilmann-Heimbach and Stefan Herms and Per Hoffman and Wolfgang Maier and Manuel Mattheisen and Morris, {Derek W} and Mowry, {Bryan J} and Betram M{\"u}ller-Mhysok and Neale, {Benjamin M} and Igor Nenadic and N{\"o}then, {Markus M} and Colm O{\textquoteright}Dushlaine and Marcella Rietschel and Ruderfer, {Douglas M} and Dan Rujescu and Schulze, {Thomas G} and Simonson, {Matthew A} and Stahl, {Eli A} and Jana Strohmaier and Witt, {Stephanie H.} and Stephan Ripke and Neale, {Benjamin M} and Aiden Corvin and Walters, {James T. R.} and Kai-How Farh and Holmans, {Peter A} and Lee, {Phil H} and Brendan Bulik-Sullivan and Collier, {David A} and Hailiang Huang and Pers, {Tune H.} and Ingrid Agartz and Esben Agerbo and Margot Albus and Madeline Alexander and Farooq Amin and Silviu-Alin Bacanu and Martin Begemann and Belliveau, {Richard A.} and Judit Bene and Bergen, {Sarah E} and Elizabeth Bevilacqua and Bigdeli, {Tim B.} and Black, {Donald W} and Richard Bruggeman and Buccola, {Nancy G} and Buckner, {Randy L.} and Byerley, {William F} and Wiepke Cahn and Guiqing Cai and Dominique Campion and Cantor, {Rita M} and Carr, {Vaughan J} and Noa Carrera and Catts, {Stanley V} and Chambert, {Kimberly D.} and Chan, {Raymond C.K.} and Chen, {Ronald Y.L.} and Chen, {Eric Y H} and Wei Cheng and Cheung, {Eric F.C.} and Chong, {Siow Ann} and {Robert Cloninger}, C. and David Cohen and Nadine Cohen and Paul Cormican and Nick Craddock and Crowley, {James J.} and David Curtis and Michael Davidson and Davis, {Kenneth L.} and Jurgen Del-Favero and Ditte Demontis and Dimitris Dikeos and Timothy Dinan and Srdjan Djurovic and Gary Donohoe and Elodie Drapeau and Jubao Duan and Frank Dudbridge and Naser Durmishi and Peter Eichhammer and Johan Eriksson and Valentina Escott-Price and Laurent Essioux and Fanous, {Ayman H} and Farrell, {Martilias S.} and Lude Franke and Robert Freedman and Freimer, {Nelson B} and Marion Friedl and Friedman, {Joseph I.} and Menachem Fromer and Lyudmila Georgieva and Ina Giegling and Paola Giusti-Rodr{\'i}guez and Stephanie Godard and Goldstein, {Jacqueline I} and Vera Golimbet and Srihari Gopal and Jacob Gratten and {de Haan}, Lieuwe and Christian Hammer and Hamshere, {Marian L.} and Mark Hansen and Thomas Hansen and Vahram Haroutunian and Hartmann, {Annette M} and Henskens, {Frans A} and Hirschhorn, {Joel N} and Per Hoffmann and Andrea Hofman and Hollegaard, {Mads V} and Hougaard, {David M.} and Masashi Ikeda and Inge Joa and Antonio Juli{\`a} and Kahn, {Ren{\'e} S} and Luba Kalaydjieva and Sena Karachanak-Yankova and Juha Karjalainen and David Kavanagh and Kennedy, {James L.} and Andrey Khrunin and Yunjung Kim and Janis Klovins and Knowles, {James A.} and Bettina Konte and Vaidutis Kucinskas and Kucinskiene, {Zita Ausrele} and Hana Kuzelova-Ptackova and K{\"a}hler, {Anna K} and Claudine Laurent and {Chee Keong}, {Jimmy Lee} and {Hong Lee}, S. and Legge, {Sophie E.} and Bernard Lerer and Miaoxin Li and Tao Li and Kung-Yee Liang and Jeffrey Lieberman and Svetlana Limborska and Loughland, {Carmel M} and Jan Lubinski and Jouko L{\"o}nnqvist and Milan Macek and Magnusson, {Patrik K E} and Maher, {Brion S} and Jacques Mallet and Sara Marsal and Morten Mattingsdal and McCarley, {Robert W} and Colm McDonald and McIntosh, {Andrew M.} and Meier, {Sandra M} and Meijer, {Carin J.} and Bela Melegh and Ingrid Melle and Mesholam-Gately, {Raquelle I.} and Andres Metspalu and Michie, {Patricia T} and Lili Milani and Vihra Milanova and Younes Mokrab and Morris, {Derek W} and Ole Mors and Murphy, {Kieran C} and Murray, {Robin M} and Inez Myin-Germeys and Bertram M{\"u}ller-Myhsok and Mari Nelis and Nertney, {Deborah A} and Gerald Nestadt and Nicodemus, {Kristin K.} and Liene Nikitina-Zake and Laura Nisenbaum and Annelie Nordin and Eadbhard O'Callaghan and O'Dushlaine, {Colm T} and {Anthony O'Neill}, F. and Oh, {Sang Yun} and Ann Olincy and Line Olsen and {van Os}, Jim and Christos Pantelis and Papadimitriou, {George N} and Sergi Papiol and Elena Parkhomenko and Pato, {Michele T} and Tiina Paunio and Milica Pejovic-Milovancevic and Perkins, {Diana O.} and Olli Pietil{\"a}inen and Jonathan Pimm and Pocklington, {Andrew J.} and John Powell and Price, {Alkes L} and Pulver, {Ann E} and Purcell, {Shaun M.} and Digby Quested and Rasmussen, {Henrik B.} and Abraham Reichenberg and Reimers, {Mark A.} and Richards, {Alexander L.} and Roffman, {Joshua L} and Panos Roussos and Veikko Salomaa and Sanders, {Alan R} and Ulrich Schall and Schubert, {Christian R.} and Schwab, {Sibylle G} and Scolnick, {Edward M.} and Scott, {Rodney J} and Seidman, {Larry J.} and Jianxin Shi and Engilbert Sigurdsson and Teimuraz Silagadze and Silverman, {Jeremy M} and Kang Sim and Petr Slominsky and Smoller, {Jordan W.} and So, {Hon Cheong} and Spencer, {Chris C A} and Stahl, {Eli A} and Hreinn Stefansson and Stacy Steinberg and Elisabeth Stogmann and Straub, {Richard E.} and Eric Strengman and {Scott Stroup}, T. and Mythily Subramaniam and Jaana Suvisaari and Svrakic, {Dragan M.} and Szatkiewicz, {Jin P.} and Erik S{\"o}derman and Srinivas Thirumalai and Draga Toncheva and Sarah Tosato and Juha Veijola and John Waddington and Dermot Walsh and Dai Wang and Qiang Wang and Webb, {Bradley T.} and Mark Weiser and Wildenauer, {Dieter B} and Williams, {Nigel M} and Watts-Williams, {Stephanie J.} and Wolen, {Aaron R.} and Wong, {Emily H.M.} and Wormley, {Brandon K.} and Xi, {Hualin Simon} and Zai, {Clement C.} and Xuebin Zheng and Fritz Zimprich and Wray, {Naomi R} and Kari Stefansson and Visscher, {Peter M} and Rolf Adolfsson and Andreassen, {Ole A.} and Blackwood, {Douglas H R} and Elvira Bramon and Buxbaum, {Joseph D} and B{\o}rglum, {Anders D} and Ariel Darvasi and Enrico Domenici and Hannelore Ehrenreich and T{\~o}nu Esko and Gejman, {Pablo V} and Michael Gill and Hugh Gurling and Hultman, {Christina M} and Nakao Iwata and Jablensky, {Assen V} and J{\"o}nsson, {Erik G} and Kendler, {Kenneth S} and George Kirov and Jo Knight and Todd Lencz and Levinson, {Douglas F} and Li, {Qingqin S.} and Jianjun Liu and Malhotra, {Anil K} and McCarroll, {Steven A} and Andrew McQuillin and Moran, {Jennifer L.} and Mortensen, {Preben B} and Mowry, {Bryan J} and N{\"o}then, {Markus M} and Ophoff, {Roel A} and Owen, {Michael J} and Aarno Palotie and Pato, {Carlos N} and Petryshen, {Tracey L.} and Danielle Posthuma and Riley, {Brien P} and Pak-Chung Sham and Pamela Sklar and {St Clair}, David and Weinberger, {Daniel R} and Wendland, {Jens R.} and Thomas Werge and Daly, {Mark J} and O'Donovan, {Michael C} and Sullivan, {Patrick F} and Keller, {Matthew C}",
year = "2016",
month = oct,
doi = "10.1371/journal.pgen.1006343",
language = "English",
volume = "12",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "10",
}
RIS
TY - JOUR
T1 - No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
AU - Johnson, Emma C.
AU - Bjelland, Douglas W.
AU - Howrigan, Daniel P
AU - Abdellaoui, Abdel
AU - Breen, Gerome
AU - Borglum, Anders D.
AU - Cichon, Sven
AU - Degenhardt, Franziska
AU - Forstner, Andreas J
AU - Frank, Josef
AU - Genovese, Giulio
AU - Heilmann-Heimbach, Stefanie
AU - Herms, Stefan
AU - Hoffman, Per
AU - Maier, Wolfgang
AU - Mattheisen, Manuel
AU - Morris, Derek W
AU - Mowry, Bryan J
AU - Müller-Mhysok, Betram
AU - Neale, Benjamin M
AU - Nenadic, Igor
AU - Nöthen, Markus M
AU - O’Dushlaine, Colm
AU - Rietschel, Marcella
AU - Ruderfer, Douglas M
AU - Rujescu, Dan
AU - Schulze, Thomas G
AU - Simonson, Matthew A
AU - Stahl, Eli A
AU - Strohmaier, Jana
AU - Witt, Stephanie H.
AU - Ripke, Stephan
AU - Neale, Benjamin M
AU - Corvin, Aiden
AU - Walters, James T. R.
AU - Farh, Kai-How
AU - Holmans, Peter A
AU - Lee, Phil H
AU - Bulik-Sullivan, Brendan
AU - Collier, David A
AU - Huang, Hailiang
AU - Pers, Tune H.
AU - Agartz, Ingrid
AU - Agerbo, Esben
AU - Albus, Margot
AU - Alexander, Madeline
AU - Amin, Farooq
AU - Bacanu, Silviu-Alin
AU - Begemann, Martin
AU - Belliveau, Richard A.
AU - Bene, Judit
AU - Bergen, Sarah E
AU - Bevilacqua, Elizabeth
AU - Bigdeli, Tim B.
AU - Black, Donald W
AU - Bruggeman, Richard
AU - Buccola, Nancy G
AU - Buckner, Randy L.
AU - Byerley, William F
AU - Cahn, Wiepke
AU - Cai, Guiqing
AU - Campion, Dominique
AU - Cantor, Rita M
AU - Carr, Vaughan J
AU - Carrera, Noa
AU - Catts, Stanley V
AU - Chambert, Kimberly D.
AU - Chan, Raymond C.K.
AU - Chen, Ronald Y.L.
AU - Chen, Eric Y H
AU - Cheng, Wei
AU - Cheung, Eric F.C.
AU - Chong, Siow Ann
AU - Robert Cloninger, C.
AU - Cohen, David
AU - Cohen, Nadine
AU - Cormican, Paul
AU - Craddock, Nick
AU - Crowley, James J.
AU - Curtis, David
AU - Davidson, Michael
AU - Davis, Kenneth L.
AU - Del-Favero, Jurgen
AU - Demontis, Ditte
AU - Dikeos, Dimitris
AU - Dinan, Timothy
AU - Djurovic, Srdjan
AU - Donohoe, Gary
AU - Drapeau, Elodie
AU - Duan, Jubao
AU - Dudbridge, Frank
AU - Durmishi, Naser
AU - Eichhammer, Peter
AU - Eriksson, Johan
AU - Escott-Price, Valentina
AU - Essioux, Laurent
AU - Fanous, Ayman H
AU - Farrell, Martilias S.
AU - Franke, Lude
AU - Freedman, Robert
AU - Freimer, Nelson B
AU - Friedl, Marion
AU - Friedman, Joseph I.
AU - Fromer, Menachem
AU - Georgieva, Lyudmila
AU - Giegling, Ina
AU - Giusti-Rodríguez, Paola
AU - Godard, Stephanie
AU - Goldstein, Jacqueline I
AU - Golimbet, Vera
AU - Gopal, Srihari
AU - Gratten, Jacob
AU - de Haan, Lieuwe
AU - Hammer, Christian
AU - Hamshere, Marian L.
AU - Hansen, Mark
AU - Hansen, Thomas
AU - Haroutunian, Vahram
AU - Hartmann, Annette M
AU - Henskens, Frans A
AU - Hirschhorn, Joel N
AU - Hoffmann, Per
AU - Hofman, Andrea
AU - Hollegaard, Mads V
AU - Hougaard, David M.
AU - Ikeda, Masashi
AU - Joa, Inge
AU - Julià, Antonio
AU - Kahn, René S
AU - Kalaydjieva, Luba
AU - Karachanak-Yankova, Sena
AU - Karjalainen, Juha
AU - Kavanagh, David
AU - Kennedy, James L.
AU - Khrunin, Andrey
AU - Kim, Yunjung
AU - Klovins, Janis
AU - Knowles, James A.
AU - Konte, Bettina
AU - Kucinskas, Vaidutis
AU - Kucinskiene, Zita Ausrele
AU - Kuzelova-Ptackova, Hana
AU - Kähler, Anna K
AU - Laurent, Claudine
AU - Chee Keong, Jimmy Lee
AU - Hong Lee, S.
AU - Legge, Sophie E.
AU - Lerer, Bernard
AU - Li, Miaoxin
AU - Li, Tao
AU - Liang, Kung-Yee
AU - Lieberman, Jeffrey
AU - Limborska, Svetlana
AU - Loughland, Carmel M
AU - Lubinski, Jan
AU - Lönnqvist, Jouko
AU - Macek, Milan
AU - Magnusson, Patrik K E
AU - Maher, Brion S
AU - Mallet, Jacques
AU - Marsal, Sara
AU - Mattingsdal, Morten
AU - McCarley, Robert W
AU - McDonald, Colm
AU - McIntosh, Andrew M.
AU - Meier, Sandra M
AU - Meijer, Carin J.
AU - Melegh, Bela
AU - Melle, Ingrid
AU - Mesholam-Gately, Raquelle I.
AU - Metspalu, Andres
AU - Michie, Patricia T
AU - Milani, Lili
AU - Milanova, Vihra
AU - Mokrab, Younes
AU - Morris, Derek W
AU - Mors, Ole
AU - Murphy, Kieran C
AU - Murray, Robin M
AU - Myin-Germeys, Inez
AU - Müller-Myhsok, Bertram
AU - Nelis, Mari
AU - Nertney, Deborah A
AU - Nestadt, Gerald
AU - Nicodemus, Kristin K.
AU - Nikitina-Zake, Liene
AU - Nisenbaum, Laura
AU - Nordin, Annelie
AU - O'Callaghan, Eadbhard
AU - O'Dushlaine, Colm T
AU - Anthony O'Neill, F.
AU - Oh, Sang Yun
AU - Olincy, Ann
AU - Olsen, Line
AU - van Os, Jim
AU - Pantelis, Christos
AU - Papadimitriou, George N
AU - Papiol, Sergi
AU - Parkhomenko, Elena
AU - Pato, Michele T
AU - Paunio, Tiina
AU - Pejovic-Milovancevic, Milica
AU - Perkins, Diana O.
AU - Pietiläinen, Olli
AU - Pimm, Jonathan
AU - Pocklington, Andrew J.
AU - Powell, John
AU - Price, Alkes L
AU - Pulver, Ann E
AU - Purcell, Shaun M.
AU - Quested, Digby
AU - Rasmussen, Henrik B.
AU - Reichenberg, Abraham
AU - Reimers, Mark A.
AU - Richards, Alexander L.
AU - Roffman, Joshua L
AU - Roussos, Panos
AU - Salomaa, Veikko
AU - Sanders, Alan R
AU - Schall, Ulrich
AU - Schubert, Christian R.
AU - Schwab, Sibylle G
AU - Scolnick, Edward M.
AU - Scott, Rodney J
AU - Seidman, Larry J.
AU - Shi, Jianxin
AU - Sigurdsson, Engilbert
AU - Silagadze, Teimuraz
AU - Silverman, Jeremy M
AU - Sim, Kang
AU - Slominsky, Petr
AU - Smoller, Jordan W.
AU - So, Hon Cheong
AU - Spencer, Chris C A
AU - Stahl, Eli A
AU - Stefansson, Hreinn
AU - Steinberg, Stacy
AU - Stogmann, Elisabeth
AU - Straub, Richard E.
AU - Strengman, Eric
AU - Scott Stroup, T.
AU - Subramaniam, Mythily
AU - Suvisaari, Jaana
AU - Svrakic, Dragan M.
AU - Szatkiewicz, Jin P.
AU - Söderman, Erik
AU - Thirumalai, Srinivas
AU - Toncheva, Draga
AU - Tosato, Sarah
AU - Veijola, Juha
AU - Waddington, John
AU - Walsh, Dermot
AU - Wang, Dai
AU - Wang, Qiang
AU - Webb, Bradley T.
AU - Weiser, Mark
AU - Wildenauer, Dieter B
AU - Williams, Nigel M
AU - Watts-Williams, Stephanie J.
AU - Wolen, Aaron R.
AU - Wong, Emily H.M.
AU - Wormley, Brandon K.
AU - Xi, Hualin Simon
AU - Zai, Clement C.
AU - Zheng, Xuebin
AU - Zimprich, Fritz
AU - Wray, Naomi R
AU - Stefansson, Kari
AU - Visscher, Peter M
AU - Adolfsson, Rolf
AU - Andreassen, Ole A.
AU - Blackwood, Douglas H R
AU - Bramon, Elvira
AU - Buxbaum, Joseph D
AU - Børglum, Anders D
AU - Darvasi, Ariel
AU - Domenici, Enrico
AU - Ehrenreich, Hannelore
AU - Esko, Tõnu
AU - Gejman, Pablo V
AU - Gill, Michael
AU - Gurling, Hugh
AU - Hultman, Christina M
AU - Iwata, Nakao
AU - Jablensky, Assen V
AU - Jönsson, Erik G
AU - Kendler, Kenneth S
AU - Kirov, George
AU - Knight, Jo
AU - Lencz, Todd
AU - Levinson, Douglas F
AU - Li, Qingqin S.
AU - Liu, Jianjun
AU - Malhotra, Anil K
AU - McCarroll, Steven A
AU - McQuillin, Andrew
AU - Moran, Jennifer L.
AU - Mortensen, Preben B
AU - Mowry, Bryan J
AU - Nöthen, Markus M
AU - Ophoff, Roel A
AU - Owen, Michael J
AU - Palotie, Aarno
AU - Pato, Carlos N
AU - Petryshen, Tracey L.
AU - Posthuma, Danielle
AU - Riley, Brien P
AU - Sham, Pak-Chung
AU - Sklar, Pamela
AU - St Clair, David
AU - Weinberger, Daniel R
AU - Wendland, Jens R.
AU - Werge, Thomas
AU - Daly, Mark J
AU - O'Donovan, Michael C
AU - Sullivan, Patrick F
AU - Keller, Matthew C
PY - 2016/10
Y1 - 2016/10
N2 - It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.
AB - It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.
U2 - 10.1371/journal.pgen.1006343
DO - 10.1371/journal.pgen.1006343
M3 - Journal article
C2 - 27792727
AN - SCOPUS:84994314495
VL - 12
JO - P L o S Genetics
JF - P L o S Genetics
SN - 1553-7390
IS - 10
M1 - e1006343
ER -
