No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

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Morten Bækgaard Thomsen, J D M Beekman, N J M Attevelt, A Takahara, A Sugiyama, K Chiba, M A Vos

The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.
OriginalsprogEngelsk
TidsskriftBritish Journal of Pharmacology
Vol/bind149
Udgave nummer8
Sider (fra-til)1039-48
Antal sider10
ISSN0007-1188
DOI
StatusUdgivet - dec. 2006

ID: 45965543