No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course
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No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. / Mikkelsen, Kristian H.; Vilsboll, Tina; Holst, Jens J.; Hartmann, Bolette; Knop, Filip K.; Frost, Morten.
I: BMC Endocrine Disorders, Bind 18, 60, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course
AU - Mikkelsen, Kristian H.
AU - Vilsboll, Tina
AU - Holst, Jens J.
AU - Hartmann, Bolette
AU - Knop, Filip K.
AU - Frost, Morten
PY - 2018
Y1 - 2018
N2 - Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers.
AB - Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers.
U2 - 10.1186/s12902-018-0291-x
DO - 10.1186/s12902-018-0291-x
M3 - Journal article
C2 - 30180841
VL - 18
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
SN - 1472-6823
M1 - 60
ER -
ID: 212423277