Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. / Trammell, Samuel A.J.; Schmidt, Mark S.; Weidemann, Benjamin J.; Redpath, Philip; Jaksch, Frank; Dellinger, Ryan W.; Li, Zhonggang; Abel, E. Dale; Migaud, Marie E.; Brenner, Charles.

I: Nature Communications, Bind 7, 12948, 10.10.2016.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Trammell, SAJ, Schmidt, MS, Weidemann, BJ, Redpath, P, Jaksch, F, Dellinger, RW, Li, Z, Abel, ED, Migaud, ME & Brenner, C 2016, 'Nicotinamide riboside is uniquely and orally bioavailable in mice and humans', Nature Communications, bind 7, 12948. https://doi.org/10.1038/ncomms12948

APA

Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, [12948]. https://doi.org/10.1038/ncomms12948

Vancouver

Trammell SAJ, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW o.a. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016 okt. 10;7. 12948. https://doi.org/10.1038/ncomms12948

Author

Trammell, Samuel A.J. ; Schmidt, Mark S. ; Weidemann, Benjamin J. ; Redpath, Philip ; Jaksch, Frank ; Dellinger, Ryan W. ; Li, Zhonggang ; Abel, E. Dale ; Migaud, Marie E. ; Brenner, Charles. / Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. I: Nature Communications. 2016 ; Bind 7.

Bibtex

@article{43b52420a7bc4dbf9f4d219b4dc57131,
title = "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans",
abstract = "Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD + with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD + metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD +, is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD + repletion.",
author = "Trammell, {Samuel A.J.} and Schmidt, {Mark S.} and Weidemann, {Benjamin J.} and Philip Redpath and Frank Jaksch and Dellinger, {Ryan W.} and Zhonggang Li and Abel, {E. Dale} and Migaud, {Marie E.} and Charles Brenner",
year = "2016",
month = oct,
day = "10",
doi = "10.1038/ncomms12948",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

AU - Trammell, Samuel A.J.

AU - Schmidt, Mark S.

AU - Weidemann, Benjamin J.

AU - Redpath, Philip

AU - Jaksch, Frank

AU - Dellinger, Ryan W.

AU - Li, Zhonggang

AU - Abel, E. Dale

AU - Migaud, Marie E.

AU - Brenner, Charles

PY - 2016/10/10

Y1 - 2016/10/10

N2 - Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD + with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD + metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD +, is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD + repletion.

AB - Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD + with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD + metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD +, is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD + repletion.

UR - http://www.scopus.com/inward/record.url?scp=84991372712&partnerID=8YFLogxK

U2 - 10.1038/ncomms12948

DO - 10.1038/ncomms12948

M3 - Journal article

C2 - 27721479

AN - SCOPUS:84991372712

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 12948

ER -

ID: 220854939