New approaches to therapy and diagnosis of diabetes

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New approaches to therapy and diagnosis of diabetes. / Hansen, Bruno A.; Lernmark, A; Owerbach, D; Welinder, B; Nielsen, Jens Høiriis.

I: Diabetologia, Bind 22, Nr. 2, 02.1982, s. 61-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hansen, BA, Lernmark, A, Owerbach, D, Welinder, B & Nielsen, JH 1982, 'New approaches to therapy and diagnosis of diabetes', Diabetologia, bind 22, nr. 2, s. 61-7.

APA

Hansen, B. A., Lernmark, A., Owerbach, D., Welinder, B., & Nielsen, J. H. (1982). New approaches to therapy and diagnosis of diabetes. Diabetologia, 22(2), 61-7.

Vancouver

Hansen BA, Lernmark A, Owerbach D, Welinder B, Nielsen JH. New approaches to therapy and diagnosis of diabetes. Diabetologia. 1982 feb;22(2):61-7.

Author

Hansen, Bruno A. ; Lernmark, A ; Owerbach, D ; Welinder, B ; Nielsen, Jens Høiriis. / New approaches to therapy and diagnosis of diabetes. I: Diabetologia. 1982 ; Bind 22, Nr. 2. s. 61-7.

Bibtex

@article{e113d6fdda1e4a16884383c53d7600d5,
title = "New approaches to therapy and diagnosis of diabetes",
abstract = "Recent progress within the field of molecular biology has resulted in the development of a new technology known as 'recombinant DNA'. This technology deals with a number of biochemical techniques for handling DNA which include: (1) cutting DNA at specific sites, (2) inserting DNA into bacteria or mammalian cells so that the cell will replicate the DNA and (3) manipulation of cloned DNA so that the host cell makes the protein for which the DNA codes [1-3]. Already a number of hormones including somatostatin, human growth hormone and human insulin [4] have been produced by these new methods. However, there are certain criteria which should be considered before new sources of hormones are generally accepted for treatment of human diseases. We shall review some of the problems which may arise in the case of insulin, by comparing the chemical and immunological properties of insulin from various sources. Recombinant DNA methods have, in addition, made it possible to study islet cell structure and function at the gene level. These studies include analysis of gene structure and of how they are transcribed and translated. Structural analyses which seem to be significant in the differential diagnosis of diabetes will be reviewed.",
keywords = "Animals, Cattle, DNA, Recombinant, Diabetes Mellitus, Humans, Insulin, Swine",
author = "Hansen, {Bruno A.} and A Lernmark and D Owerbach and B Welinder and Nielsen, {Jens H{\o}iriis}",
year = "1982",
month = "2",
language = "English",
volume = "22",
pages = "61--7",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - New approaches to therapy and diagnosis of diabetes

AU - Hansen, Bruno A.

AU - Lernmark, A

AU - Owerbach, D

AU - Welinder, B

AU - Nielsen, Jens Høiriis

PY - 1982/2

Y1 - 1982/2

N2 - Recent progress within the field of molecular biology has resulted in the development of a new technology known as 'recombinant DNA'. This technology deals with a number of biochemical techniques for handling DNA which include: (1) cutting DNA at specific sites, (2) inserting DNA into bacteria or mammalian cells so that the cell will replicate the DNA and (3) manipulation of cloned DNA so that the host cell makes the protein for which the DNA codes [1-3]. Already a number of hormones including somatostatin, human growth hormone and human insulin [4] have been produced by these new methods. However, there are certain criteria which should be considered before new sources of hormones are generally accepted for treatment of human diseases. We shall review some of the problems which may arise in the case of insulin, by comparing the chemical and immunological properties of insulin from various sources. Recombinant DNA methods have, in addition, made it possible to study islet cell structure and function at the gene level. These studies include analysis of gene structure and of how they are transcribed and translated. Structural analyses which seem to be significant in the differential diagnosis of diabetes will be reviewed.

AB - Recent progress within the field of molecular biology has resulted in the development of a new technology known as 'recombinant DNA'. This technology deals with a number of biochemical techniques for handling DNA which include: (1) cutting DNA at specific sites, (2) inserting DNA into bacteria or mammalian cells so that the cell will replicate the DNA and (3) manipulation of cloned DNA so that the host cell makes the protein for which the DNA codes [1-3]. Already a number of hormones including somatostatin, human growth hormone and human insulin [4] have been produced by these new methods. However, there are certain criteria which should be considered before new sources of hormones are generally accepted for treatment of human diseases. We shall review some of the problems which may arise in the case of insulin, by comparing the chemical and immunological properties of insulin from various sources. Recombinant DNA methods have, in addition, made it possible to study islet cell structure and function at the gene level. These studies include analysis of gene structure and of how they are transcribed and translated. Structural analyses which seem to be significant in the differential diagnosis of diabetes will be reviewed.

KW - Animals

KW - Cattle

KW - DNA, Recombinant

KW - Diabetes Mellitus

KW - Humans

KW - Insulin

KW - Swine

M3 - Journal article

C2 - 7037514

VL - 22

SP - 61

EP - 67

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 2

ER -

ID: 47975380