Muscle paralysis and myosin loss in a patient with cancer cachexia

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Muscle paralysis and myosin loss in a patient with cancer cachexia. / Banduseela, V.; Ochala, J.; Lamberg, K.; Kalimo, H.; Larsson, Lars.

I: Acta Myologica, Bind 26, Nr. 3, 12.2007, s. 136-144.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Banduseela, V, Ochala, J, Lamberg, K, Kalimo, H & Larsson, L 2007, 'Muscle paralysis and myosin loss in a patient with cancer cachexia', Acta Myologica, bind 26, nr. 3, s. 136-144.

APA

Banduseela, V., Ochala, J., Lamberg, K., Kalimo, H., & Larsson, L. (2007). Muscle paralysis and myosin loss in a patient with cancer cachexia. Acta Myologica, 26(3), 136-144.

Vancouver

Banduseela V, Ochala J, Lamberg K, Kalimo H, Larsson L. Muscle paralysis and myosin loss in a patient with cancer cachexia. Acta Myologica. 2007 dec.;26(3):136-144.

Author

Banduseela, V. ; Ochala, J. ; Lamberg, K. ; Kalimo, H. ; Larsson, Lars. / Muscle paralysis and myosin loss in a patient with cancer cachexia. I: Acta Myologica. 2007 ; Bind 26, Nr. 3. s. 136-144.

Bibtex

@article{143d83db0c3747e7af2f6bfb350a35f1,
title = "Muscle paralysis and myosin loss in a patient with cancer cachexia",
abstract = "Cancer cachexia has a significant negative effect on quality of life, survival and the response to treatment. Recent in vitro and experimental animal studies have shown that myosin may be the primary target of the muscle wasting associated with cancer cachexia. In this study, we have extended these analyses to detailed studies of regulation of myofibrillar protein synthesis at the gene level, myofibrillar protein expression and regulation of muscle contraction at the muscle cell level in a 63-year old man with a newly diagnosed small cell lung cancer and a rapidly progressing lower extremity muscle wasting and paralysis. A significant preferential loss of the motor protein myosin together with a downregulation of protein synthesis at the transcriptional level was observed in the patient with cancer cachexia. This had a significant negative impact on muscle fiber size as well as maximum force normalized to muscle fiber cross-sectional area (specific tension).",
keywords = "Force generation capacity, MAFBx, MuRF1, Myosin, Skinned muscle fibers",
author = "V. Banduseela and J. Ochala and K. Lamberg and H. Kalimo and Lars Larsson",
year = "2007",
month = dec,
language = "English",
volume = "26",
pages = "136--144",
journal = "Acta Myologica",
issn = "1128-2460",
publisher = "Pacini Editore SpA",
number = "3",

}

RIS

TY - JOUR

T1 - Muscle paralysis and myosin loss in a patient with cancer cachexia

AU - Banduseela, V.

AU - Ochala, J.

AU - Lamberg, K.

AU - Kalimo, H.

AU - Larsson, Lars

PY - 2007/12

Y1 - 2007/12

N2 - Cancer cachexia has a significant negative effect on quality of life, survival and the response to treatment. Recent in vitro and experimental animal studies have shown that myosin may be the primary target of the muscle wasting associated with cancer cachexia. In this study, we have extended these analyses to detailed studies of regulation of myofibrillar protein synthesis at the gene level, myofibrillar protein expression and regulation of muscle contraction at the muscle cell level in a 63-year old man with a newly diagnosed small cell lung cancer and a rapidly progressing lower extremity muscle wasting and paralysis. A significant preferential loss of the motor protein myosin together with a downregulation of protein synthesis at the transcriptional level was observed in the patient with cancer cachexia. This had a significant negative impact on muscle fiber size as well as maximum force normalized to muscle fiber cross-sectional area (specific tension).

AB - Cancer cachexia has a significant negative effect on quality of life, survival and the response to treatment. Recent in vitro and experimental animal studies have shown that myosin may be the primary target of the muscle wasting associated with cancer cachexia. In this study, we have extended these analyses to detailed studies of regulation of myofibrillar protein synthesis at the gene level, myofibrillar protein expression and regulation of muscle contraction at the muscle cell level in a 63-year old man with a newly diagnosed small cell lung cancer and a rapidly progressing lower extremity muscle wasting and paralysis. A significant preferential loss of the motor protein myosin together with a downregulation of protein synthesis at the transcriptional level was observed in the patient with cancer cachexia. This had a significant negative impact on muscle fiber size as well as maximum force normalized to muscle fiber cross-sectional area (specific tension).

KW - Force generation capacity

KW - MAFBx

KW - MuRF1

KW - Myosin

KW - Skinned muscle fibers

UR - http://www.scopus.com/inward/record.url?scp=43449097205&partnerID=8YFLogxK

M3 - Journal article

C2 - 18646562

AN - SCOPUS:43449097205

VL - 26

SP - 136

EP - 144

JO - Acta Myologica

JF - Acta Myologica

SN - 1128-2460

IS - 3

ER -

ID: 245665467