Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans

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Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. / Boushel, Robert Christopher; Gnaiger, Erich; Calbet, Jose A L; Gonzalez-Alonso, Jose; Wright-Paradis, Cynthia; Sondergaard, Hans; Ara, Ignacio; Helge, Jørn W; Saltin, Bengt.

I: Mitochondrion, Bind 11, Nr. 2, 2011, s. 303-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

Harvard

Boushel, RC, Gnaiger, E, Calbet, JAL, Gonzalez-Alonso, J, Wright-Paradis, C, Sondergaard, H, Ara, I, Helge, JW & Saltin, B 2011, 'Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans', Mitochondrion, bind 11, nr. 2, s. 303-7. https://doi.org/10.1016/j.mito.2010.12.006

APA

Boushel, R. C., Gnaiger, E., Calbet, J. A. L., Gonzalez-Alonso, J., Wright-Paradis, C., Sondergaard, H., Ara, I., Helge, J. W., & Saltin, B. (2011). Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion, 11(2), 303-7. https://doi.org/10.1016/j.mito.2010.12.006

Vancouver

Boushel RC, Gnaiger E, Calbet JAL, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H o.a. Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion. 2011;11(2):303-7. https://doi.org/10.1016/j.mito.2010.12.006

Author

Boushel, Robert Christopher ; Gnaiger, Erich ; Calbet, Jose A L ; Gonzalez-Alonso, Jose ; Wright-Paradis, Cynthia ; Sondergaard, Hans ; Ara, Ignacio ; Helge, Jørn W ; Saltin, Bengt. / Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. I: Mitochondrion. 2011 ; Bind 11, Nr. 2. s. 303-7.

Bibtex

@article{70e4c8a70e0a437caa0d98217e35182d,

title = "Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans",

abstract = "Across a wide range of species and body mass a close matching exists between maximal conductive oxygen delivery and mitochondrial respiratory rate. In this study we investigated in humans how closely in-vivo maximal oxygen consumption (VO(2) max) is matched to state 3 muscle mitochondrial respiration. High resolution respirometry was used to quantify mitochondrial respiration from the biopsies of arm and leg muscles while in-vivo arm and leg VO(2) were determined by the Fick method during leg cycling and arm cranking. We hypothesized that muscle mitochondrial respiratory rate exceeds that of systemic oxygen delivery. The state 3 mitochondrial respiration of the deltoid muscle (4.3±0.4 mmol o(2)kg(-1) min(-1)) was similar to the in-vivo VO(2) during maximal arm cranking (4.7±0.5 mmol O(2) kg(-1) min(-1)) with 6 kg muscle. In contrast, the mitochondrial state 3 of the quadriceps was 6.9±0.5 mmol O(2) kg(-1) min(-1), exceeding the in-vivo leg VO(2) max (5.0±0.2 mmol O(2) kg(-1) min(-1)) during leg cycling with 20 kg muscle (P",

keywords = "Adult, Female, Humans, Male, Mitochondria, Muscle, Oxygen",

author = "Boushel, {Robert Christopher} and Erich Gnaiger and Calbet, {Jose A L} and Jose Gonzalez-Alonso and Cynthia Wright-Paradis and Hans Sondergaard and Ignacio Ara and Helge, {J{\o}rn W} and Bengt Saltin",

year = "2011",

doi = "10.1016/j.mito.2010.12.006",

language = "English",

volume = "11",

pages = "303--7",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans

AU - Boushel, Robert Christopher

AU - Gnaiger, Erich

AU - Calbet, Jose A L

AU - Gonzalez-Alonso, Jose

AU - Wright-Paradis, Cynthia

AU - Sondergaard, Hans

AU - Ara, Ignacio

AU - Helge, Jørn W

AU - Saltin, Bengt

PY - 2011

Y1 - 2011

N2 - Across a wide range of species and body mass a close matching exists between maximal conductive oxygen delivery and mitochondrial respiratory rate. In this study we investigated in humans how closely in-vivo maximal oxygen consumption (VO(2) max) is matched to state 3 muscle mitochondrial respiration. High resolution respirometry was used to quantify mitochondrial respiration from the biopsies of arm and leg muscles while in-vivo arm and leg VO(2) were determined by the Fick method during leg cycling and arm cranking. We hypothesized that muscle mitochondrial respiratory rate exceeds that of systemic oxygen delivery. The state 3 mitochondrial respiration of the deltoid muscle (4.3±0.4 mmol o(2)kg(-1) min(-1)) was similar to the in-vivo VO(2) during maximal arm cranking (4.7±0.5 mmol O(2) kg(-1) min(-1)) with 6 kg muscle. In contrast, the mitochondrial state 3 of the quadriceps was 6.9±0.5 mmol O(2) kg(-1) min(-1), exceeding the in-vivo leg VO(2) max (5.0±0.2 mmol O(2) kg(-1) min(-1)) during leg cycling with 20 kg muscle (P

AB - Across a wide range of species and body mass a close matching exists between maximal conductive oxygen delivery and mitochondrial respiratory rate. In this study we investigated in humans how closely in-vivo maximal oxygen consumption (VO(2) max) is matched to state 3 muscle mitochondrial respiration. High resolution respirometry was used to quantify mitochondrial respiration from the biopsies of arm and leg muscles while in-vivo arm and leg VO(2) were determined by the Fick method during leg cycling and arm cranking. We hypothesized that muscle mitochondrial respiratory rate exceeds that of systemic oxygen delivery. The state 3 mitochondrial respiration of the deltoid muscle (4.3±0.4 mmol o(2)kg(-1) min(-1)) was similar to the in-vivo VO(2) during maximal arm cranking (4.7±0.5 mmol O(2) kg(-1) min(-1)) with 6 kg muscle. In contrast, the mitochondrial state 3 of the quadriceps was 6.9±0.5 mmol O(2) kg(-1) min(-1), exceeding the in-vivo leg VO(2) max (5.0±0.2 mmol O(2) kg(-1) min(-1)) during leg cycling with 20 kg muscle (P

KW - Adult

KW - Female

KW - Humans

KW - Male

KW - Mitochondria, Muscle

KW - Oxygen

U2 - 10.1016/j.mito.2010.12.006

DO - 10.1016/j.mito.2010.12.006

M3 - Journal article

C2 - 21147270

VL - 11

SP - 303

EP - 307

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

IS - 2

ER -

ID: 33815716

Biomedicinsk Institut