Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

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Standard

Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention. / Hansen, Anders E.; Henriksen, Jonas R.; Jølck, Rasmus I.; Fliedner, Frederikke P.; Bruun, Linda M.; Scherman, Jonas; Jensen, Andreas I.; Af Rosenschöld, Munck; Moorman, Lilah; Kurbegovic, Sorel; de Blanck, Steen R.; Larsen, Klaus R.; Clementsen, Paul F.; Christensen, Anders N.; Clausen, Mads H.; Wang, Wenbo; Kempen, Paul; Christensen, Merete; Viby, Niels Erik; Persson, Gitte; Larsen, Rasmus; Conradsen, Knut; McEvoy, Fintan J.; Kjaer, Andreas; Eriksen, Thomas; Andresen, Thomas L.

I: Science Advances, Bind 6, Nr. 34, eabb5353, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, AE, Henriksen, JR, Jølck, RI, Fliedner, FP, Bruun, LM, Scherman, J, Jensen, AI, Af Rosenschöld, M, Moorman, L, Kurbegovic, S, de Blanck, SR, Larsen, KR, Clementsen, PF, Christensen, AN, Clausen, MH, Wang, W, Kempen, P, Christensen, M, Viby, NE, Persson, G, Larsen, R, Conradsen, K, McEvoy, FJ, Kjaer, A, Eriksen, T & Andresen, TL 2020, 'Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention', Science Advances, bind 6, nr. 34, eabb5353. https://doi.org/10.1126/sciadv.abb5353

APA

Hansen, A. E., Henriksen, J. R., Jølck, R. I., Fliedner, F. P., Bruun, L. M., Scherman, J., Jensen, A. I., Af Rosenschöld, M., Moorman, L., Kurbegovic, S., de Blanck, S. R., Larsen, K. R., Clementsen, P. F., Christensen, A. N., Clausen, M. H., Wang, W., Kempen, P., Christensen, M., Viby, N. E., ... Andresen, T. L. (2020). Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention. Science Advances, 6(34), [eabb5353]. https://doi.org/10.1126/sciadv.abb5353

Vancouver

Hansen AE, Henriksen JR, Jølck RI, Fliedner FP, Bruun LM, Scherman J o.a. Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention. Science Advances. 2020;6(34). eabb5353. https://doi.org/10.1126/sciadv.abb5353

Author

Hansen, Anders E. ; Henriksen, Jonas R. ; Jølck, Rasmus I. ; Fliedner, Frederikke P. ; Bruun, Linda M. ; Scherman, Jonas ; Jensen, Andreas I. ; Af Rosenschöld, Munck ; Moorman, Lilah ; Kurbegovic, Sorel ; de Blanck, Steen R. ; Larsen, Klaus R. ; Clementsen, Paul F. ; Christensen, Anders N. ; Clausen, Mads H. ; Wang, Wenbo ; Kempen, Paul ; Christensen, Merete ; Viby, Niels Erik ; Persson, Gitte ; Larsen, Rasmus ; Conradsen, Knut ; McEvoy, Fintan J. ; Kjaer, Andreas ; Eriksen, Thomas ; Andresen, Thomas L. / Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention. I: Science Advances. 2020 ; Bind 6, Nr. 34.

Bibtex

@article{9b6f55548a684b2fb49ab044bb57af50,
title = "Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention",
abstract = "Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery. ",
author = "Hansen, {Anders E.} and Henriksen, {Jonas R.} and J{\o}lck, {Rasmus I.} and Fliedner, {Frederikke P.} and Bruun, {Linda M.} and Jonas Scherman and Jensen, {Andreas I.} and {Af Rosensch{\"o}ld}, Munck and Lilah Moorman and Sorel Kurbegovic and {de Blanck}, {Steen R.} and Larsen, {Klaus R.} and Clementsen, {Paul F.} and Christensen, {Anders N.} and Clausen, {Mads H.} and Wenbo Wang and Paul Kempen and Merete Christensen and Viby, {Niels Erik} and Gitte Persson and Rasmus Larsen and Knut Conradsen and McEvoy, {Fintan J.} and Andreas Kjaer and Thomas Eriksen and Andresen, {Thomas L.}",
year = "2020",
doi = "10.1126/sciadv.abb5353",
language = "English",
volume = "6",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "34",

}

RIS

TY - JOUR

T1 - Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

AU - Hansen, Anders E.

AU - Henriksen, Jonas R.

AU - Jølck, Rasmus I.

AU - Fliedner, Frederikke P.

AU - Bruun, Linda M.

AU - Scherman, Jonas

AU - Jensen, Andreas I.

AU - Af Rosenschöld, Munck

AU - Moorman, Lilah

AU - Kurbegovic, Sorel

AU - de Blanck, Steen R.

AU - Larsen, Klaus R.

AU - Clementsen, Paul F.

AU - Christensen, Anders N.

AU - Clausen, Mads H.

AU - Wang, Wenbo

AU - Kempen, Paul

AU - Christensen, Merete

AU - Viby, Niels Erik

AU - Persson, Gitte

AU - Larsen, Rasmus

AU - Conradsen, Knut

AU - McEvoy, Fintan J.

AU - Kjaer, Andreas

AU - Eriksen, Thomas

AU - Andresen, Thomas L.

PY - 2020

Y1 - 2020

N2 - Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

AB - Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

U2 - 10.1126/sciadv.abb5353

DO - 10.1126/sciadv.abb5353

M3 - Journal article

C2 - 32875113

AN - SCOPUS:85090180117

VL - 6

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 34

M1 - eabb5353

ER -

ID: 250920355