Monitoring of blood oxygenation in brain by resonance Raman spectroscopy

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Standard

Monitoring of blood oxygenation in brain by resonance Raman spectroscopy. / Brazhe, Nadezda A.; Thomsen, Kirsten; Lønstrup, Micael; Brazhe, Alexey R.; Nikelshparg, Evelina I.; Maksimov, Georgy V; Lauritzen, Martin; Sosnovtseva, Olga.

I: Journal of Biophotonics, Bind 11, Nr. 6, e201700311, 2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Brazhe, NA, Thomsen, K, Lønstrup, M, Brazhe, AR, Nikelshparg, EI, Maksimov, GV, Lauritzen, M & Sosnovtseva, O 2018, 'Monitoring of blood oxygenation in brain by resonance Raman spectroscopy', Journal of Biophotonics, bind 11, nr. 6, e201700311. https://doi.org/10.1002/jbio.201700311

APA

Brazhe, N. A., Thomsen, K., Lønstrup, M., Brazhe, A. R., Nikelshparg, E. I., Maksimov, G. V., Lauritzen, M., & Sosnovtseva, O. (2018). Monitoring of blood oxygenation in brain by resonance Raman spectroscopy. Journal of Biophotonics, 11(6), [e201700311]. https://doi.org/10.1002/jbio.201700311

Vancouver

Brazhe NA, Thomsen K, Lønstrup M, Brazhe AR, Nikelshparg EI, Maksimov GV o.a. Monitoring of blood oxygenation in brain by resonance Raman spectroscopy. Journal of Biophotonics. 2018;11(6). e201700311. https://doi.org/10.1002/jbio.201700311

Author

Brazhe, Nadezda A. ; Thomsen, Kirsten ; Lønstrup, Micael ; Brazhe, Alexey R. ; Nikelshparg, Evelina I. ; Maksimov, Georgy V ; Lauritzen, Martin ; Sosnovtseva, Olga. / Monitoring of blood oxygenation in brain by resonance Raman spectroscopy. I: Journal of Biophotonics. 2018 ; Bind 11, Nr. 6.

Bibtex

@article{a2cf5ca939244defabf6333245c303ba,
title = "Monitoring of blood oxygenation in brain by resonance Raman spectroscopy",
abstract = "Blood oxygenation in cerebral vessels is an essential parameter to evaluate brain function and to investigate the coupling between local blood flow and neuronal activity. We apply resonance Raman spectroscopy in vivo to study hemoglobin oxygenation in cortex vessels of anesthetized ventilated mice. We demonstrate that the pairs of Raman peaks at 1355 and1375 cm-1(symmetric vibrations of pyrrol half-rings in the heme molecule), 1552 and 1585 cm-1and 1602 and 1638 cm-1(vibrations of methine bridges in heme molecule) are reliable markers for quantitative estimation of the relative amount of oxyhemoglobin in venules, arterioles, and capillaries. In vivo measurements of blood oxygenation in the cortex of mice ventilated with inspiratory gas mixtures containing different amounts of oxygen - normoxia, hyperoxia and hypoxia - validate the proposed approach. Our method allows to visualize blood saturation with O2in different microvascular networks.",
author = "Brazhe, {Nadezda A.} and Kirsten Thomsen and Micael L{\o}nstrup and Brazhe, {Alexey R.} and Nikelshparg, {Evelina I.} and Maksimov, {Georgy V} and Martin Lauritzen and Olga Sosnovtseva",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
doi = "10.1002/jbio.201700311",
language = "English",
volume = "11",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "6",

}

RIS

TY - JOUR

T1 - Monitoring of blood oxygenation in brain by resonance Raman spectroscopy

AU - Brazhe, Nadezda A.

AU - Thomsen, Kirsten

AU - Lønstrup, Micael

AU - Brazhe, Alexey R.

AU - Nikelshparg, Evelina I.

AU - Maksimov, Georgy V

AU - Lauritzen, Martin

AU - Sosnovtseva, Olga

N1 - This article is protected by copyright. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Blood oxygenation in cerebral vessels is an essential parameter to evaluate brain function and to investigate the coupling between local blood flow and neuronal activity. We apply resonance Raman spectroscopy in vivo to study hemoglobin oxygenation in cortex vessels of anesthetized ventilated mice. We demonstrate that the pairs of Raman peaks at 1355 and1375 cm-1(symmetric vibrations of pyrrol half-rings in the heme molecule), 1552 and 1585 cm-1and 1602 and 1638 cm-1(vibrations of methine bridges in heme molecule) are reliable markers for quantitative estimation of the relative amount of oxyhemoglobin in venules, arterioles, and capillaries. In vivo measurements of blood oxygenation in the cortex of mice ventilated with inspiratory gas mixtures containing different amounts of oxygen - normoxia, hyperoxia and hypoxia - validate the proposed approach. Our method allows to visualize blood saturation with O2in different microvascular networks.

AB - Blood oxygenation in cerebral vessels is an essential parameter to evaluate brain function and to investigate the coupling between local blood flow and neuronal activity. We apply resonance Raman spectroscopy in vivo to study hemoglobin oxygenation in cortex vessels of anesthetized ventilated mice. We demonstrate that the pairs of Raman peaks at 1355 and1375 cm-1(symmetric vibrations of pyrrol half-rings in the heme molecule), 1552 and 1585 cm-1and 1602 and 1638 cm-1(vibrations of methine bridges in heme molecule) are reliable markers for quantitative estimation of the relative amount of oxyhemoglobin in venules, arterioles, and capillaries. In vivo measurements of blood oxygenation in the cortex of mice ventilated with inspiratory gas mixtures containing different amounts of oxygen - normoxia, hyperoxia and hypoxia - validate the proposed approach. Our method allows to visualize blood saturation with O2in different microvascular networks.

U2 - 10.1002/jbio.201700311

DO - 10.1002/jbio.201700311

M3 - Journal article

C2 - 29603883

VL - 11

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 6

M1 - e201700311

ER -

ID: 194810065