Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Evidence is emerging that elevated serum free fatty acids (hyperlipidemia) contribute to the pathogenesis of type-2-diabetes, and lipotoxicity is observed in many cell types. We recently published data indicating lipotoxic effects of simulated hyperlipidemia also in GLP-1-secreting cells, where the antidiabetic drug metformin conferred protection from lipoapoptosis. The aim of the present study was to identify mechanisms involved in mediating lipotoxicity and metformin lipoprotection in GLP-1 secreting cells. These signaling events triggered by simulated hyperlipidemia may underlie reduced GLP-1 secretion in diabetic subjects, and metformin lipoprotection by metformin could explain elevated plasma GLP-1 levels in diabetic patients on chronic metformin therapy. The present study may thus identify potential molecular targets for increasing endogenous GLP-1 secretion through enhanced viability of GLP-1 secreting cells in diabetic hyperlipidemia and obesity.
Originalsprog | Engelsk |
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Tidsskrift | Biochemical and Biophysical Research Communications |
Vol/bind | 427 |
Udgave nummer | 1 |
Sider (fra-til) | 91-5 |
Antal sider | 5 |
ISSN | 0006-291X |
DOI | |
Status | Udgivet - 12 okt. 2012 |
ID: 45840730