Kv7 channel trafficking by the microtubule network in vascular smooth muscle

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Kv7 channel trafficking by the microtubule network in vascular smooth muscle. / Jepps, Thomas A.

I: Acta Physiologica, Bind 232, Nr. 3, e13692, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Jepps, TA 2021, 'Kv7 channel trafficking by the microtubule network in vascular smooth muscle', Acta Physiologica, bind 232, nr. 3, e13692. https://doi.org/10.1111/apha.13692

APA

Jepps, T. A. (2021). Kv7 channel trafficking by the microtubule network in vascular smooth muscle. Acta Physiologica, 232(3), [e13692]. https://doi.org/10.1111/apha.13692

Vancouver

Jepps TA. Kv7 channel trafficking by the microtubule network in vascular smooth muscle. Acta Physiologica. 2021;232(3). e13692. https://doi.org/10.1111/apha.13692

Author

Jepps, Thomas A. / Kv7 channel trafficking by the microtubule network in vascular smooth muscle. I: Acta Physiologica. 2021 ; Bind 232, Nr. 3.

Bibtex

@article{2e29c65ef4bf4a7989d925317210d58e,
title = "Kv7 channel trafficking by the microtubule network in vascular smooth muscle",
abstract = "In arterial smooth muscle cells, changes in availability of integral membrane proteins influence the regulation of blood flow and blood pressure, which is critical for human health. However, the mechanisms that coordinate the trafficking and membrane expression of specific receptors and ion channels in vascular smooth muscle are poorly understood. In the vasculature, very little is known about microtubules, which form a road network upon which proteins can be transported to and from the cell membrane. This review article summarizes the impact of the microtubule network on arterial contractility, highlighting the importance of the network, with an emphasis on our recent findings regarding the trafficking of the voltage-dependent Kv7 channels.",
keywords = "caveolae, dynein, KCNQ, Kv7, microtubules, vascular, PROTEIN-KINASE-C, GATED POTASSIUM CHANNEL, K(V)7 CHANNELS, ION CHANNELS, DEPENDENT MODULATION, VOLTAGE SENSOR, K+ CURRENTS, DISRUPTION, ACTIVATION, EXPRESSION",
author = "Jepps, {Thomas A.}",
year = "2021",
doi = "10.1111/apha.13692",
language = "English",
volume = "232",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Kv7 channel trafficking by the microtubule network in vascular smooth muscle

AU - Jepps, Thomas A.

PY - 2021

Y1 - 2021

N2 - In arterial smooth muscle cells, changes in availability of integral membrane proteins influence the regulation of blood flow and blood pressure, which is critical for human health. However, the mechanisms that coordinate the trafficking and membrane expression of specific receptors and ion channels in vascular smooth muscle are poorly understood. In the vasculature, very little is known about microtubules, which form a road network upon which proteins can be transported to and from the cell membrane. This review article summarizes the impact of the microtubule network on arterial contractility, highlighting the importance of the network, with an emphasis on our recent findings regarding the trafficking of the voltage-dependent Kv7 channels.

AB - In arterial smooth muscle cells, changes in availability of integral membrane proteins influence the regulation of blood flow and blood pressure, which is critical for human health. However, the mechanisms that coordinate the trafficking and membrane expression of specific receptors and ion channels in vascular smooth muscle are poorly understood. In the vasculature, very little is known about microtubules, which form a road network upon which proteins can be transported to and from the cell membrane. This review article summarizes the impact of the microtubule network on arterial contractility, highlighting the importance of the network, with an emphasis on our recent findings regarding the trafficking of the voltage-dependent Kv7 channels.

KW - caveolae

KW - dynein

KW - KCNQ

KW - Kv7

KW - microtubules

KW - vascular

KW - PROTEIN-KINASE-C

KW - GATED POTASSIUM CHANNEL

KW - K(V)7 CHANNELS

KW - ION CHANNELS

KW - DEPENDENT MODULATION

KW - VOLTAGE SENSOR

KW - K+ CURRENTS

KW - DISRUPTION

KW - ACTIVATION

KW - EXPRESSION

U2 - 10.1111/apha.13692

DO - 10.1111/apha.13692

M3 - Review

C2 - 34021973

VL - 232

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 3

M1 - e13692

ER -

ID: 272073189