Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges. / Hoeeg, Cecilie; Dolatshahi-Pirouz, Alireza; Follin, Bjarke.

I: Gels, Bind 7, Nr. 1, 7, 2021, s. 1-21.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Hoeeg, C, Dolatshahi-Pirouz, A & Follin, B 2021, 'Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges', Gels, bind 7, nr. 1, 7, s. 1-21. https://doi.org/10.3390/gels7010007

APA

Hoeeg, C., Dolatshahi-Pirouz, A., & Follin, B. (2021). Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges. Gels, 7(1), 1-21. [7]. https://doi.org/10.3390/gels7010007

Vancouver

Hoeeg C, Dolatshahi-Pirouz A, Follin B. Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges. Gels. 2021;7(1):1-21. 7. https://doi.org/10.3390/gels7010007

Author

Hoeeg, Cecilie ; Dolatshahi-Pirouz, Alireza ; Follin, Bjarke. / Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges. I: Gels. 2021 ; Bind 7, Nr. 1. s. 1-21.

Bibtex

@article{88c83647b6de4c7eaaf0ac9ad0493273,
title = "Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges",
abstract = "Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation.",
keywords = "Cardiac disease, Cell therapy, Delivery, Heart failure, Hydrogel, Mesenchymal stem cell, Regenerative therapy",
author = "Cecilie Hoeeg and Alireza Dolatshahi-Pirouz and Bjarke Follin",
year = "2021",
doi = "10.3390/gels7010007",
language = "English",
volume = "7",
pages = "1--21",
journal = "Gels",
issn = "2310-2861",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "1",

}

RIS

TY - JOUR

T1 - Injectable hydrogels for improving cardiac cell therapy—in vivo evidence and translational challenges

AU - Hoeeg, Cecilie

AU - Dolatshahi-Pirouz, Alireza

AU - Follin, Bjarke

PY - 2021

Y1 - 2021

N2 - Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation.

AB - Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation.

KW - Cardiac disease

KW - Cell therapy

KW - Delivery

KW - Heart failure

KW - Hydrogel

KW - Mesenchymal stem cell

KW - Regenerative therapy

U2 - 10.3390/gels7010007

DO - 10.3390/gels7010007

M3 - Review

C2 - 33499287

AN - SCOPUS:85099947373

VL - 7

SP - 1

EP - 21

JO - Gels

JF - Gels

SN - 2310-2861

IS - 1

M1 - 7

ER -

ID: 256512398