Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial

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Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men : a randomized controlled trial. / Nordby, Pernille; Rosenkilde, Mads ; Ploug, Thorkil; Westh, Karina; Feigh, Michael; Nielsen, Ninna B; Helge, Jørn Wulff; Stallknecht, Bente.

I: Journal of Applied Physiology, Bind 118, Nr. 7, 01.04.2015, s. 803-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nordby, P, Rosenkilde, M, Ploug, T, Westh, K, Feigh, M, Nielsen, NB, Helge, JW & Stallknecht, B 2015, 'Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial', Journal of Applied Physiology, bind 118, nr. 7, s. 803-10. https://doi.org/10.1152/japplphysiol.00715.2014

APA

Nordby, P., Rosenkilde, M., Ploug, T., Westh, K., Feigh, M., Nielsen, N. B., ... Stallknecht, B. (2015). Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial. Journal of Applied Physiology, 118(7), 803-10. https://doi.org/10.1152/japplphysiol.00715.2014

Vancouver

Nordby P, Rosenkilde M, Ploug T, Westh K, Feigh M, Nielsen NB o.a. Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial. Journal of Applied Physiology. 2015 apr 1;118(7):803-10. https://doi.org/10.1152/japplphysiol.00715.2014

Author

Nordby, Pernille ; Rosenkilde, Mads ; Ploug, Thorkil ; Westh, Karina ; Feigh, Michael ; Nielsen, Ninna B ; Helge, Jørn Wulff ; Stallknecht, Bente. / Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men : a randomized controlled trial. I: Journal of Applied Physiology. 2015 ; Bind 118, Nr. 7. s. 803-10.

Bibtex

@article{033b993e1ebf4d95a84845a42021d844,
title = "Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial",
abstract = "Endurance training increases peak fat oxidation (PFO) during exercise, but whether this is independent of changes in body weight is not known. The aim of the present study was to investigate the effects of endurance training with or without weight loss or a diet-induced weight loss on PFO and on key skeletal muscle mitochondrial proteins involved in fat oxidation. Sixty moderately overweight, sedentary but otherwise healthy men were randomized to 12 wk of training (T), diet (D), training and increased caloric intake (T-iD), or continuous sedentary control (C). Isoenergetic deficits corresponding to 600 kcal/day were comprised of endurance exercise for T and caloric restriction for D. T-iD completed similar training but was not in 600 kcal deficit because of dietary replacement. PFO and the exercise intensity at which this occurred (FatMax) were measured by a submaximal exercise test and calculated by polynomial regression. As intended by study design, a similar weight loss was observed in T (-5.9 ± 0.7 kg) and D (-5.2 ± 0.8 kg), whereas T-iD (-1.0 ± 0.5 kg) and C (0.1 ± 0.6 kg) remained weight stable. PFO increased to a similar extent with 42{\%} in T [0.16 g/min; 95{\%} confidence intervals (CI): 0.02; 0.30, P = 0.02] and 41{\%} in T-iD (0.16 g/min; 95{\%} CI: 0.01; 0.30, P = 0.04) compared with C, but did not increase in D (P = 0.96). In addition, the analysis of covariance showed that changes in both PFO (0.10 g/min; 95{\%} CI: 0.03; 0.17, P = 0.03) and FatMax (6.3{\%} V̇o2max; 95{\%} CI: 1.4; 11.3, P < 0.01) were independently explained by endurance training. In conclusion, endurance training per se increases PFO in moderately overweight men.",
author = "Pernille Nordby and Mads Rosenkilde and Thorkil Ploug and Karina Westh and Michael Feigh and Nielsen, {Ninna B} and Helge, {J{\o}rn Wulff} and Bente Stallknecht",
note = "Copyright {\circledC} 2015 the American Physiological Society.",
year = "2015",
month = "4",
day = "1",
doi = "10.1152/japplphysiol.00715.2014",
language = "English",
volume = "118",
pages = "803--10",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "7",

}

RIS

TY - JOUR

T1 - Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men

T2 - a randomized controlled trial

AU - Nordby, Pernille

AU - Rosenkilde, Mads

AU - Ploug, Thorkil

AU - Westh, Karina

AU - Feigh, Michael

AU - Nielsen, Ninna B

AU - Helge, Jørn Wulff

AU - Stallknecht, Bente

N1 - Copyright © 2015 the American Physiological Society.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Endurance training increases peak fat oxidation (PFO) during exercise, but whether this is independent of changes in body weight is not known. The aim of the present study was to investigate the effects of endurance training with or without weight loss or a diet-induced weight loss on PFO and on key skeletal muscle mitochondrial proteins involved in fat oxidation. Sixty moderately overweight, sedentary but otherwise healthy men were randomized to 12 wk of training (T), diet (D), training and increased caloric intake (T-iD), or continuous sedentary control (C). Isoenergetic deficits corresponding to 600 kcal/day were comprised of endurance exercise for T and caloric restriction for D. T-iD completed similar training but was not in 600 kcal deficit because of dietary replacement. PFO and the exercise intensity at which this occurred (FatMax) were measured by a submaximal exercise test and calculated by polynomial regression. As intended by study design, a similar weight loss was observed in T (-5.9 ± 0.7 kg) and D (-5.2 ± 0.8 kg), whereas T-iD (-1.0 ± 0.5 kg) and C (0.1 ± 0.6 kg) remained weight stable. PFO increased to a similar extent with 42% in T [0.16 g/min; 95% confidence intervals (CI): 0.02; 0.30, P = 0.02] and 41% in T-iD (0.16 g/min; 95% CI: 0.01; 0.30, P = 0.04) compared with C, but did not increase in D (P = 0.96). In addition, the analysis of covariance showed that changes in both PFO (0.10 g/min; 95% CI: 0.03; 0.17, P = 0.03) and FatMax (6.3% V̇o2max; 95% CI: 1.4; 11.3, P < 0.01) were independently explained by endurance training. In conclusion, endurance training per se increases PFO in moderately overweight men.

AB - Endurance training increases peak fat oxidation (PFO) during exercise, but whether this is independent of changes in body weight is not known. The aim of the present study was to investigate the effects of endurance training with or without weight loss or a diet-induced weight loss on PFO and on key skeletal muscle mitochondrial proteins involved in fat oxidation. Sixty moderately overweight, sedentary but otherwise healthy men were randomized to 12 wk of training (T), diet (D), training and increased caloric intake (T-iD), or continuous sedentary control (C). Isoenergetic deficits corresponding to 600 kcal/day were comprised of endurance exercise for T and caloric restriction for D. T-iD completed similar training but was not in 600 kcal deficit because of dietary replacement. PFO and the exercise intensity at which this occurred (FatMax) were measured by a submaximal exercise test and calculated by polynomial regression. As intended by study design, a similar weight loss was observed in T (-5.9 ± 0.7 kg) and D (-5.2 ± 0.8 kg), whereas T-iD (-1.0 ± 0.5 kg) and C (0.1 ± 0.6 kg) remained weight stable. PFO increased to a similar extent with 42% in T [0.16 g/min; 95% confidence intervals (CI): 0.02; 0.30, P = 0.02] and 41% in T-iD (0.16 g/min; 95% CI: 0.01; 0.30, P = 0.04) compared with C, but did not increase in D (P = 0.96). In addition, the analysis of covariance showed that changes in both PFO (0.10 g/min; 95% CI: 0.03; 0.17, P = 0.03) and FatMax (6.3% V̇o2max; 95% CI: 1.4; 11.3, P < 0.01) were independently explained by endurance training. In conclusion, endurance training per se increases PFO in moderately overweight men.

U2 - 10.1152/japplphysiol.00715.2014

DO - 10.1152/japplphysiol.00715.2014

M3 - Journal article

VL - 118

SP - 803

EP - 810

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 7

ER -

ID: 135415848