Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men. / Janus, Charlotte; Vistisen, Dorte; Amadid, Hanan; Witte, Daniel R; Lauritzen, Torsten; Brage, Søren; Bjerregaard, Anne-Louise; Hansen, Torben; Holst, Jens Juul; Jørgensen, Marit Eika; Pedersen, Oluf; Færch, Kristine; Torekov, Signe.

I: Endocrine Connections, Bind 8, Nr. 12, 2019, s. 1607–1617.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Janus, C, Vistisen, D, Amadid, H, Witte, DR, Lauritzen, T, Brage, S, Bjerregaard, A-L, Hansen, T, Holst, JJ, Jørgensen, ME, Pedersen, O, Færch, K & Torekov, S 2019, 'Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men', Endocrine Connections, bind 8, nr. 12, s. 1607–1617. https://doi.org/10.1530/EC-19-0408

APA

Janus, C., Vistisen, D., Amadid, H., Witte, D. R., Lauritzen, T., Brage, S., ... Torekov, S. (2019). Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men. Endocrine Connections, 8(12), 1607–1617. https://doi.org/10.1530/EC-19-0408

Vancouver

Janus C, Vistisen D, Amadid H, Witte DR, Lauritzen T, Brage S o.a. Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men. Endocrine Connections. 2019;8(12):1607–1617. https://doi.org/10.1530/EC-19-0408

Author

Janus, Charlotte ; Vistisen, Dorte ; Amadid, Hanan ; Witte, Daniel R ; Lauritzen, Torsten ; Brage, Søren ; Bjerregaard, Anne-Louise ; Hansen, Torben ; Holst, Jens Juul ; Jørgensen, Marit Eika ; Pedersen, Oluf ; Færch, Kristine ; Torekov, Signe. / Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men. I: Endocrine Connections. 2019 ; Bind 8, Nr. 12. s. 1607–1617.

Bibtex

@article{5bb0f4ac2cb940dd9f7ad127eec213f9,
title = "Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men",
abstract = "RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.RESULTS: In 703 men, fasting GLP-1 concentrations were 20{\%} lower (95{\%}CI: -33;-3{\%}, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2{\%} lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16{\%} greater at peak 30 min (1;33{\%}, PrAUC0-30=0.04) and 20{\%} greater at full response (3;40{\%}, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.",
author = "Charlotte Janus and Dorte Vistisen and Hanan Amadid and Witte, {Daniel R} and Torsten Lauritzen and S{\o}ren Brage and Anne-Louise Bjerregaard and Torben Hansen and Holst, {Jens Juul} and J{\o}rgensen, {Marit Eika} and Oluf Pedersen and Kristine F{\ae}rch and Signe Torekov",
year = "2019",
doi = "10.1530/EC-19-0408",
language = "English",
volume = "8",
pages = "1607–1617",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd.",
number = "12",

}

RIS

TY - JOUR

T1 - Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men

AU - Janus, Charlotte

AU - Vistisen, Dorte

AU - Amadid, Hanan

AU - Witte, Daniel R

AU - Lauritzen, Torsten

AU - Brage, Søren

AU - Bjerregaard, Anne-Louise

AU - Hansen, Torben

AU - Holst, Jens Juul

AU - Jørgensen, Marit Eika

AU - Pedersen, Oluf

AU - Færch, Kristine

AU - Torekov, Signe

PY - 2019

Y1 - 2019

N2 - RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.RESULTS: In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.

AB - RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.RESULTS: In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.

U2 - 10.1530/EC-19-0408

DO - 10.1530/EC-19-0408

M3 - Journal article

C2 - 31804964

VL - 8

SP - 1607

EP - 1617

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 12

ER -

ID: 231716183