Glucagon does not directly stimulate pituitary secretion of ACTH, GH or copeptin
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Glucagon does not directly stimulate pituitary secretion of ACTH, GH or copeptin. / Stangerup, Ida; Kjeldsen, Sasha A.S.; Richter, Michael M.; Jensen, Nicole J.; Rungby, Jørgen; Haugaard, Steen Bendix; Georg, Birgitte; Hannibal, Jens; Møllgård, Kjeld; Wewer Albrechtsen, Nicolai J.; Bjørnbak Holst, Camilla.
I: Peptides, Bind 176, 171213, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Glucagon does not directly stimulate pituitary secretion of ACTH, GH or copeptin
AU - Stangerup, Ida
AU - Kjeldsen, Sasha A.S.
AU - Richter, Michael M.
AU - Jensen, Nicole J.
AU - Rungby, Jørgen
AU - Haugaard, Steen Bendix
AU - Georg, Birgitte
AU - Hannibal, Jens
AU - Møllgård, Kjeld
AU - Wewer Albrechtsen, Nicolai J.
AU - Bjørnbak Holst, Camilla
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Glucagon is best known for its contribution to glucose regulation through activation of the glucagon receptor (GCGR), primarily located in the liver. However, glucagon's impact on other organs may also contribute to its potent effects in health and disease. Given that glucagon-based medicine is entering the arena of anti-obesity drugs, elucidating extrahepatic actions of glucagon are of increased importance. It has been reported that glucagon may stimulate secretion of arginine-vasopressin (AVP)/copeptin, growth hormone (GH) and adrenocorticotrophic hormone (ACTH) from the pituitary gland. Nevertheless, the mechanisms and whether GCGR is present in human pituitary are unknown. In this study we found that intravenous administration of 0.2 mg glucagon to 14 healthy subjects was not associated with increases in plasma concentrations of copeptin, GH, ACTH or cortisol over a 120-min period. GCGR immunoreactivity was present in the anterior pituitary but not in cells containing GH or ACTH. Collectively, glucagon may not directly stimulate secretion of GH, ACTH or AVP/copeptin in humans but may instead be involved in yet unidentified pituitary functions.
AB - Glucagon is best known for its contribution to glucose regulation through activation of the glucagon receptor (GCGR), primarily located in the liver. However, glucagon's impact on other organs may also contribute to its potent effects in health and disease. Given that glucagon-based medicine is entering the arena of anti-obesity drugs, elucidating extrahepatic actions of glucagon are of increased importance. It has been reported that glucagon may stimulate secretion of arginine-vasopressin (AVP)/copeptin, growth hormone (GH) and adrenocorticotrophic hormone (ACTH) from the pituitary gland. Nevertheless, the mechanisms and whether GCGR is present in human pituitary are unknown. In this study we found that intravenous administration of 0.2 mg glucagon to 14 healthy subjects was not associated with increases in plasma concentrations of copeptin, GH, ACTH or cortisol over a 120-min period. GCGR immunoreactivity was present in the anterior pituitary but not in cells containing GH or ACTH. Collectively, glucagon may not directly stimulate secretion of GH, ACTH or AVP/copeptin in humans but may instead be involved in yet unidentified pituitary functions.
KW - Adrenocorticotrophic hormone
KW - Copeptin
KW - Glucagon
KW - Growth hormone
KW - Pituitary
U2 - 10.1016/j.peptides.2024.171213
DO - 10.1016/j.peptides.2024.171213
M3 - Journal article
C2 - 38604379
AN - SCOPUS:85190271121
VL - 176
JO - Peptides
JF - Peptides
SN - 0196-9781
M1 - 171213
ER -
ID: 389505736