Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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Standard

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. / Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renström, Frida; Quaye, Lydia; Eicher, John D.; Hayes, James E.; Cornelis, Marilyn; Kutalik, Zoltan; Lim, Elise; Luan, Jian’an; Huffman, Jennifer E.; Zhang, Weihua; Zhao, Wei; Griffin, Paula J.; Haller, Toomas; Ahmad, Shafqat; Marques-Vidal, Pedro M.; Bien, Stephanie; Yengo, Loic; Teumer, Alexander; Smith, Albert Vernon; Kumari, Meena; Harder, Marie Neergaard; Justesen, Johanne Marie; Kleber, Marcus E; Hollensted, Mette; Aadahl, Mette; Færch, Kristine; Grarup, Niels; Vestergaard, Henrik; Sørensen, Thorkild I.A.; Linneberg, Allan; Hansen, Torben; Pedersen, Oluf; Loos, Ruth J.F.; Kilpeläinen, Tuomas O.; CHARGE Consortium; EPIC-InterAct Consortium; PAGE Consortium.

I: PLOS Genetics, Bind 13, Nr. 4, e1006528, 01.04.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Graff, M, Scott, RA, Justice, AE, Young, KL, Feitosa, MF, Barata, L, Winkler, TW, Chu, AY, Mahajan, A, Hadley, D, Xue, L, Workalemahu, T, Heard-Costa, NL, den Hoed, M, Ahluwalia, TS, Qi, Q, Ngwa, JS, Renström, F, Quaye, L, Eicher, JD, Hayes, JE, Cornelis, M, Kutalik, Z, Lim, E, Luan, J, Huffman, JE, Zhang, W, Zhao, W, Griffin, PJ, Haller, T, Ahmad, S, Marques-Vidal, PM, Bien, S, Yengo, L, Teumer, A, Smith, AV, Kumari, M, Harder, MN, Justesen, JM, Kleber, ME, Hollensted, M, Aadahl, M, Færch, K, Grarup, N, Vestergaard, H, Sørensen, TIA, Linneberg, A, Hansen, T, Pedersen, O, Loos, RJF, Kilpeläinen, TO, CHARGE Consortium, EPIC-InterAct Consortium & PAGE Consortium 2017, 'Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults', PLOS Genetics, bind 13, nr. 4, e1006528. https://doi.org/10.1371/journal.pgen.1006528

APA

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., ... PAGE Consortium (2017). Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLOS Genetics, 13(4), [e1006528]. https://doi.org/10.1371/journal.pgen.1006528

Vancouver

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L o.a. Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLOS Genetics. 2017 apr 1;13(4). e1006528. https://doi.org/10.1371/journal.pgen.1006528

Author

Graff, Mariaelisa ; Scott, Robert A. ; Justice, Anne E. ; Young, Kristin L. ; Feitosa, Mary F. ; Barata, Llilda ; Winkler, Thomas W. ; Chu, Audrey Y. ; Mahajan, Anubha ; Hadley, David ; Xue, Luting ; Workalemahu, Tsegaselassie ; Heard-Costa, Nancy L. ; den Hoed, Marcel ; Ahluwalia, Tarunveer S. ; Qi, Qibin ; Ngwa, Julius S. ; Renström, Frida ; Quaye, Lydia ; Eicher, John D. ; Hayes, James E. ; Cornelis, Marilyn ; Kutalik, Zoltan ; Lim, Elise ; Luan, Jian’an ; Huffman, Jennifer E. ; Zhang, Weihua ; Zhao, Wei ; Griffin, Paula J. ; Haller, Toomas ; Ahmad, Shafqat ; Marques-Vidal, Pedro M. ; Bien, Stephanie ; Yengo, Loic ; Teumer, Alexander ; Smith, Albert Vernon ; Kumari, Meena ; Harder, Marie Neergaard ; Justesen, Johanne Marie ; Kleber, Marcus E ; Hollensted, Mette ; Aadahl, Mette ; Færch, Kristine ; Grarup, Niels ; Vestergaard, Henrik ; Sørensen, Thorkild I.A. ; Linneberg, Allan ; Hansen, Torben ; Pedersen, Oluf ; Loos, Ruth J.F. ; Kilpeläinen, Tuomas O. ; CHARGE Consortium ; EPIC-InterAct Consortium ; PAGE Consortium. / Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. I: PLOS Genetics. 2017 ; Bind 13, Nr. 4.

Bibtex

@article{90e8aefd6fbc42c09d2299150c375cbf,
title = "Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults",
abstract = "Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23{\%} of participants were categorized as inactive and 77{\%} as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30{\%} in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.",
author = "Mariaelisa Graff and Scott, {Robert A.} and Justice, {Anne E.} and Young, {Kristin L.} and Feitosa, {Mary F.} and Llilda Barata and Winkler, {Thomas W.} and Chu, {Audrey Y.} and Anubha Mahajan and David Hadley and Luting Xue and Tsegaselassie Workalemahu and Heard-Costa, {Nancy L.} and {den Hoed}, Marcel and Ahluwalia, {Tarunveer S.} and Qibin Qi and Ngwa, {Julius S.} and Frida Renstr{\"o}m and Lydia Quaye and Eicher, {John D.} and Hayes, {James E.} and Marilyn Cornelis and Zoltan Kutalik and Elise Lim and Jian’an Luan and Huffman, {Jennifer E.} and Weihua Zhang and Wei Zhao and Griffin, {Paula J.} and Toomas Haller and Shafqat Ahmad and Marques-Vidal, {Pedro M.} and Stephanie Bien and Loic Yengo and Alexander Teumer and Smith, {Albert Vernon} and Meena Kumari and Harder, {Marie Neergaard} and Justesen, {Johanne Marie} and Kleber, {Marcus E} and Mette Hollensted and Mette Aadahl and Kristine F{\ae}rch and Niels Grarup and Henrik Vestergaard and S{\o}rensen, {Thorkild I.A.} and Allan Linneberg and Torben Hansen and Oluf Pedersen and Loos, {Ruth J.F.} and Kilpel{\"a}inen, {Tuomas O.} and {CHARGE Consortium} and {EPIC-InterAct Consortium} and {PAGE Consortium}",
note = "Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults (PLoS genetics (2017) 13 4 (e1006528)) DOI: 10.1371/journal.pgen.1006972",
year = "2017",
month = "4",
day = "1",
doi = "10.1371/journal.pgen.1006528",
language = "English",
volume = "13",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

AU - Graff, Mariaelisa

AU - Scott, Robert A.

AU - Justice, Anne E.

AU - Young, Kristin L.

AU - Feitosa, Mary F.

AU - Barata, Llilda

AU - Winkler, Thomas W.

AU - Chu, Audrey Y.

AU - Mahajan, Anubha

AU - Hadley, David

AU - Xue, Luting

AU - Workalemahu, Tsegaselassie

AU - Heard-Costa, Nancy L.

AU - den Hoed, Marcel

AU - Ahluwalia, Tarunveer S.

AU - Qi, Qibin

AU - Ngwa, Julius S.

AU - Renström, Frida

AU - Quaye, Lydia

AU - Eicher, John D.

AU - Hayes, James E.

AU - Cornelis, Marilyn

AU - Kutalik, Zoltan

AU - Lim, Elise

AU - Luan, Jian’an

AU - Huffman, Jennifer E.

AU - Zhang, Weihua

AU - Zhao, Wei

AU - Griffin, Paula J.

AU - Haller, Toomas

AU - Ahmad, Shafqat

AU - Marques-Vidal, Pedro M.

AU - Bien, Stephanie

AU - Yengo, Loic

AU - Teumer, Alexander

AU - Smith, Albert Vernon

AU - Kumari, Meena

AU - Harder, Marie Neergaard

AU - Justesen, Johanne Marie

AU - Kleber, Marcus E

AU - Hollensted, Mette

AU - Aadahl, Mette

AU - Færch, Kristine

AU - Grarup, Niels

AU - Vestergaard, Henrik

AU - Sørensen, Thorkild I.A.

AU - Linneberg, Allan

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Loos, Ruth J.F.

AU - Kilpeläinen, Tuomas O.

AU - CHARGE Consortium

AU - EPIC-InterAct Consortium

AU - PAGE Consortium

N1 - Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults (PLoS genetics (2017) 13 4 (e1006528)) DOI: 10.1371/journal.pgen.1006972

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

AB - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

UR - http://www.scopus.com/inward/record.url?scp=85018450983&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1006528

DO - 10.1371/journal.pgen.1006528

M3 - Journal article

C2 - 28448500

AN - SCOPUS:85018450983

VL - 13

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

IS - 4

M1 - e1006528

ER -

ID: 192106168