Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
TidsskriftInternational Journal of Obesity
Udgave nummer2
Sider (fra-til)365-70
Antal sider6
StatusUdgivet - 2007

ID: 40246606