From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals?

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

From workout to molecular switches : How does skeletal muscle produce, sense, and transduce subcellular redox signals? / Henriquez-Olguin, Carlos; Meneses-Valdes, Roberto; Kritsiligkou, Paraskevi; Fuentes-Lemus, Eduardo.

I: Free Radical Biology and Medicine, Bind 209, 2023, s. 355-365.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Henriquez-Olguin, C, Meneses-Valdes, R, Kritsiligkou, P & Fuentes-Lemus, E 2023, 'From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals?', Free Radical Biology and Medicine, bind 209, s. 355-365. https://doi.org/10.1016/j.freeradbiomed.2023.10.404

APA

Henriquez-Olguin, C., Meneses-Valdes, R., Kritsiligkou, P., & Fuentes-Lemus, E. (2023). From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals? Free Radical Biology and Medicine, 209, 355-365. https://doi.org/10.1016/j.freeradbiomed.2023.10.404

Vancouver

Henriquez-Olguin C, Meneses-Valdes R, Kritsiligkou P, Fuentes-Lemus E. From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals? Free Radical Biology and Medicine. 2023;209:355-365. https://doi.org/10.1016/j.freeradbiomed.2023.10.404

Author

Henriquez-Olguin, Carlos ; Meneses-Valdes, Roberto ; Kritsiligkou, Paraskevi ; Fuentes-Lemus, Eduardo. / From workout to molecular switches : How does skeletal muscle produce, sense, and transduce subcellular redox signals?. I: Free Radical Biology and Medicine. 2023 ; Bind 209. s. 355-365.

Bibtex

@article{df1e49528886498187ac23208b58136d,
title = "From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals?",
abstract = "Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute exercise introduces a multifaceted intracellular stress, with numerous post-translational modifications believed to underpin the health benefits of sustained exercise training. Reactive oxygen species (ROS) are posited to serve as second messengers, triggering cytoprotective adaptations such as the upregulation of enzymatic scavenger systems. However, a significant knowledge gap exists between the generation of oxidants in muscle and the exact mechanisms driving muscle adaptations. This review delves into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise. We propose that the subcellular regulation of specific redox modifications is key to ensuring specificity in the intracellular response.",
keywords = "Exercise training, Hydrogen peroxide, Mitochondria, Redox signaling, Skeletal muscle",
author = "Carlos Henriquez-Olguin and Roberto Meneses-Valdes and Paraskevi Kritsiligkou and Eduardo Fuentes-Lemus",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.freeradbiomed.2023.10.404",
language = "English",
volume = "209",
pages = "355--365",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - From workout to molecular switches

T2 - How does skeletal muscle produce, sense, and transduce subcellular redox signals?

AU - Henriquez-Olguin, Carlos

AU - Meneses-Valdes, Roberto

AU - Kritsiligkou, Paraskevi

AU - Fuentes-Lemus, Eduardo

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute exercise introduces a multifaceted intracellular stress, with numerous post-translational modifications believed to underpin the health benefits of sustained exercise training. Reactive oxygen species (ROS) are posited to serve as second messengers, triggering cytoprotective adaptations such as the upregulation of enzymatic scavenger systems. However, a significant knowledge gap exists between the generation of oxidants in muscle and the exact mechanisms driving muscle adaptations. This review delves into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise. We propose that the subcellular regulation of specific redox modifications is key to ensuring specificity in the intracellular response.

AB - Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute exercise introduces a multifaceted intracellular stress, with numerous post-translational modifications believed to underpin the health benefits of sustained exercise training. Reactive oxygen species (ROS) are posited to serve as second messengers, triggering cytoprotective adaptations such as the upregulation of enzymatic scavenger systems. However, a significant knowledge gap exists between the generation of oxidants in muscle and the exact mechanisms driving muscle adaptations. This review delves into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise. We propose that the subcellular regulation of specific redox modifications is key to ensuring specificity in the intracellular response.

KW - Exercise training

KW - Hydrogen peroxide

KW - Mitochondria

KW - Redox signaling

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85175547049&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2023.10.404

DO - 10.1016/j.freeradbiomed.2023.10.404

M3 - Review

C2 - 37923089

AN - SCOPUS:85175547049

VL - 209

SP - 355

EP - 365

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

ER -

ID: 372326836