FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit

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Standard

FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. / Flippo, Kyle H.; Trammell, Samuel A.J.; Gillum, Matthew P.; Aklan, Iltan; Perez, Misty B.; Yavuz, Yavuz; Smith, Nicholas K.; Jensen-Cody, Sharon O.; Zhou, Bolu; Claflin, Kristin E.; Beierschmitt, Amy; Fink-Jensen, Anders; Knop, Filip K.; Palmour, Roberta M.; Grueter, Brad A.; Atasoy, Deniz; Potthoff, Matthew J.

I: Cell Metabolism, Bind 34, Nr. 2, 2022, s. 317-328.e6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Flippo, KH, Trammell, SAJ, Gillum, MP, Aklan, I, Perez, MB, Yavuz, Y, Smith, NK, Jensen-Cody, SO, Zhou, B, Claflin, KE, Beierschmitt, A, Fink-Jensen, A, Knop, FK, Palmour, RM, Grueter, BA, Atasoy, D & Potthoff, MJ 2022, 'FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit', Cell Metabolism, bind 34, nr. 2, s. 317-328.e6. https://doi.org/10.1016/j.cmet.2021.12.024

APA

Flippo, K. H., Trammell, S. A. J., Gillum, M. P., Aklan, I., Perez, M. B., Yavuz, Y., Smith, N. K., Jensen-Cody, S. O., Zhou, B., Claflin, K. E., Beierschmitt, A., Fink-Jensen, A., Knop, F. K., Palmour, R. M., Grueter, B. A., Atasoy, D., & Potthoff, M. J. (2022). FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metabolism, 34(2), 317-328.e6. https://doi.org/10.1016/j.cmet.2021.12.024

Vancouver

Flippo KH, Trammell SAJ, Gillum MP, Aklan I, Perez MB, Yavuz Y o.a. FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metabolism. 2022;34(2):317-328.e6. https://doi.org/10.1016/j.cmet.2021.12.024

Author

Flippo, Kyle H. ; Trammell, Samuel A.J. ; Gillum, Matthew P. ; Aklan, Iltan ; Perez, Misty B. ; Yavuz, Yavuz ; Smith, Nicholas K. ; Jensen-Cody, Sharon O. ; Zhou, Bolu ; Claflin, Kristin E. ; Beierschmitt, Amy ; Fink-Jensen, Anders ; Knop, Filip K. ; Palmour, Roberta M. ; Grueter, Brad A. ; Atasoy, Deniz ; Potthoff, Matthew J. / FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. I: Cell Metabolism. 2022 ; Bind 34, Nr. 2. s. 317-328.e6.

Bibtex

@article{5558ef09119e4fd5b337919a302392e2,
title = "FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit",
abstract = "Excessive alcohol consumption is a major health and social issue in our society. Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) suppresses alcohol consumption through actions in the brain in rodents, and genome-wide association studies have identified single nucleotide polymorphisms in genes involved with FGF21 signaling as being associated with increased alcohol consumption in humans. However, the neural circuit(s) through which FGF21 signals to suppress alcohol consumption are unknown, as are its effects on alcohol consumption in higher organisms. Here, we demonstrate that administration of an FGF21 analog to alcohol-preferring non-human primates reduces alcohol intake by 50%. Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala. Our results illustrate how FGF21 suppresses alcohol consumption through a specific population of neurons in the brain and demonstrate its therapeutic potential in non-human primate models of excessive alcohol consumption.",
keywords = "alcohol, basolateral amygdala, betaklotho, brain, FGF21, hepatokine, liver, nucleus accumbens",
author = "Flippo, {Kyle H.} and Trammell, {Samuel A.J.} and Gillum, {Matthew P.} and Iltan Aklan and Perez, {Misty B.} and Yavuz Yavuz and Smith, {Nicholas K.} and Jensen-Cody, {Sharon O.} and Bolu Zhou and Claflin, {Kristin E.} and Amy Beierschmitt and Anders Fink-Jensen and Knop, {Filip K.} and Palmour, {Roberta M.} and Grueter, {Brad A.} and Deniz Atasoy and Potthoff, {Matthew J.}",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2022",
doi = "10.1016/j.cmet.2021.12.024",
language = "English",
volume = "34",
pages = "317--328.e6",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit

AU - Flippo, Kyle H.

AU - Trammell, Samuel A.J.

AU - Gillum, Matthew P.

AU - Aklan, Iltan

AU - Perez, Misty B.

AU - Yavuz, Yavuz

AU - Smith, Nicholas K.

AU - Jensen-Cody, Sharon O.

AU - Zhou, Bolu

AU - Claflin, Kristin E.

AU - Beierschmitt, Amy

AU - Fink-Jensen, Anders

AU - Knop, Filip K.

AU - Palmour, Roberta M.

AU - Grueter, Brad A.

AU - Atasoy, Deniz

AU - Potthoff, Matthew J.

N1 - Publisher Copyright: © 2021

PY - 2022

Y1 - 2022

N2 - Excessive alcohol consumption is a major health and social issue in our society. Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) suppresses alcohol consumption through actions in the brain in rodents, and genome-wide association studies have identified single nucleotide polymorphisms in genes involved with FGF21 signaling as being associated with increased alcohol consumption in humans. However, the neural circuit(s) through which FGF21 signals to suppress alcohol consumption are unknown, as are its effects on alcohol consumption in higher organisms. Here, we demonstrate that administration of an FGF21 analog to alcohol-preferring non-human primates reduces alcohol intake by 50%. Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala. Our results illustrate how FGF21 suppresses alcohol consumption through a specific population of neurons in the brain and demonstrate its therapeutic potential in non-human primate models of excessive alcohol consumption.

AB - Excessive alcohol consumption is a major health and social issue in our society. Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) suppresses alcohol consumption through actions in the brain in rodents, and genome-wide association studies have identified single nucleotide polymorphisms in genes involved with FGF21 signaling as being associated with increased alcohol consumption in humans. However, the neural circuit(s) through which FGF21 signals to suppress alcohol consumption are unknown, as are its effects on alcohol consumption in higher organisms. Here, we demonstrate that administration of an FGF21 analog to alcohol-preferring non-human primates reduces alcohol intake by 50%. Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala. Our results illustrate how FGF21 suppresses alcohol consumption through a specific population of neurons in the brain and demonstrate its therapeutic potential in non-human primate models of excessive alcohol consumption.

KW - alcohol

KW - basolateral amygdala

KW - betaklotho

KW - brain

KW - FGF21

KW - hepatokine

KW - liver

KW - nucleus accumbens

U2 - 10.1016/j.cmet.2021.12.024

DO - 10.1016/j.cmet.2021.12.024

M3 - Journal article

C2 - 35108517

AN - SCOPUS:85123632088

VL - 34

SP - 317-328.e6

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 2

ER -

ID: 291362907