Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man

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Standard

Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1 : A Functional GLP-1–Renal Axis in Man. / Asmar, Ali; Cramon, Per K; Simonsen, Lene; Asmar, Meena; Sorensen, Charlotte M; Madsbad, Sten; Moro, Cedric; Hartmann, Bolette; Jensen, Boye L; Holst, Jens J; Bülow, Jens.

I: The Journal of clinical endocrinology and metabolism, Bind 104, Nr. 7, 07.2019, s. 2509–2519.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Asmar, A, Cramon, PK, Simonsen, L, Asmar, M, Sorensen, CM, Madsbad, S, Moro, C, Hartmann, B, Jensen, BL, Holst, JJ & Bülow, J 2019, 'Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man', The Journal of clinical endocrinology and metabolism, bind 104, nr. 7, s. 2509–2519. https://doi.org/10.1210/jc.2019-00004

APA

Asmar, A., Cramon, P. K., Simonsen, L., Asmar, M., Sorensen, C. M., Madsbad, S., ... Bülow, J. (2019). Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man. The Journal of clinical endocrinology and metabolism, 104(7), 2509–2519. https://doi.org/10.1210/jc.2019-00004

Vancouver

Asmar A, Cramon PK, Simonsen L, Asmar M, Sorensen CM, Madsbad S o.a. Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man. The Journal of clinical endocrinology and metabolism. 2019 jul;104(7):2509–2519. https://doi.org/10.1210/jc.2019-00004

Author

Asmar, Ali ; Cramon, Per K ; Simonsen, Lene ; Asmar, Meena ; Sorensen, Charlotte M ; Madsbad, Sten ; Moro, Cedric ; Hartmann, Bolette ; Jensen, Boye L ; Holst, Jens J ; Bülow, Jens. / Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1 : A Functional GLP-1–Renal Axis in Man. I: The Journal of clinical endocrinology and metabolism. 2019 ; Bind 104, Nr. 7. s. 2509–2519.

Bibtex

@article{9e0dd9151000466382c67ed1f1d35cfb,
title = "Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man",
abstract = "PURPOSE: We have previously demonstrated that glucagon-like peptide (GLP)-1, does not affect renal hemodynamics or function under baseline conditions in healthy individuals and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The present study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume loaded individuals.METHODS: Under fixed sodium intake, 8 healthy men were examined twice in random order during a 3-hour infusion of either GLP-1(1.5 pmol kg-1 min-1) or vehicle together with an intravenous infusion of 0.9{\%} NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake/release of hormones and ions were measured using Fick's Principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared to vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.",
author = "Ali Asmar and Cramon, {Per K} and Lene Simonsen and Meena Asmar and Sorensen, {Charlotte M} and Sten Madsbad and Cedric Moro and Bolette Hartmann and Jensen, {Boye L} and Holst, {Jens J} and Jens B{\"u}low",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "7",
doi = "10.1210/jc.2019-00004",
language = "English",
volume = "104",
pages = "2509–2519",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1

T2 - A Functional GLP-1–Renal Axis in Man

AU - Asmar, Ali

AU - Cramon, Per K

AU - Simonsen, Lene

AU - Asmar, Meena

AU - Sorensen, Charlotte M

AU - Madsbad, Sten

AU - Moro, Cedric

AU - Hartmann, Bolette

AU - Jensen, Boye L

AU - Holst, Jens J

AU - Bülow, Jens

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/7

Y1 - 2019/7

N2 - PURPOSE: We have previously demonstrated that glucagon-like peptide (GLP)-1, does not affect renal hemodynamics or function under baseline conditions in healthy individuals and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The present study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume loaded individuals.METHODS: Under fixed sodium intake, 8 healthy men were examined twice in random order during a 3-hour infusion of either GLP-1(1.5 pmol kg-1 min-1) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake/release of hormones and ions were measured using Fick's Principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared to vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.

AB - PURPOSE: We have previously demonstrated that glucagon-like peptide (GLP)-1, does not affect renal hemodynamics or function under baseline conditions in healthy individuals and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The present study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume loaded individuals.METHODS: Under fixed sodium intake, 8 healthy men were examined twice in random order during a 3-hour infusion of either GLP-1(1.5 pmol kg-1 min-1) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake/release of hormones and ions were measured using Fick's Principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared to vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.

U2 - 10.1210/jc.2019-00004

DO - 10.1210/jc.2019-00004

M3 - Journal article

VL - 104

SP - 2509

EP - 2519

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 214747974