Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

In this paper, we provide an overview of the evolution of the definition of hyperglycemia during the past century and the alterations in glucose dynamics that cause fasting and postprandial hyperglycemia. We discuss how extensive mechanistic, physiological research into the factors and pathways that regulate the appearance of glucose in the circulation and its uptake and metabolism by tissues and organs has contributed knowledge that has advanced our understanding of different types of hyperglycemia, namely prediabetes and diabetes and their subtypes (impaired fasting plasma glucose, impaired glucose tolerance, combined impaired fasting plasma glucose, impaired glucose tolerance, type 1 diabetes, type 2 diabetes, gestational diabetes mellitus), their relationships with medical complications, and how to prevent and treat hyperglycemia.
OriginalsprogEngelsk
TidsskriftPhysiological Reviews
Vol/bind103
Udgave nummer1
Sider (fra-til)7-30
Antal sider24
ISSN0031-9333
DOI
StatusUdgivet - 2023

Bibliografisk note

CURIS 2023 NEXS 002

ID: 308368083