Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

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Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. / Li, Hui; Yao, Qi; Mariscal, Alberto Garcia; Wu, Xudong; Hülse, Justus; Pedersen, Esben; Helin, Kristian; Waisman, Ari; Vinkel, Caroline; Thomsen, Simon Francis; Avgustinova, Alexandra; Benitah, Salvador Aznar; Lovato, Paola; Norsgaard, Hanne; Mortensen, Mette Sidsel; Veng, Lone; Rozell, Björn; Brakebusch, Cord.

I: Nature Communications, Bind 9, Nr. 1, 1420, 2018, s. 1-18.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Li, H, Yao, Q, Mariscal, AG, Wu, X, Hülse, J, Pedersen, E, Helin, K, Waisman, A, Vinkel, C, Thomsen, SF, Avgustinova, A, Benitah, SA, Lovato, P, Norsgaard, H, Mortensen, MS, Veng, L, Rozell, B & Brakebusch, C 2018, 'Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation', Nature Communications, bind 9, nr. 1, 1420, s. 1-18. https://doi.org/10.1038/s41467-018-03704-z

APA

Li, H., Yao, Q., Mariscal, A. G., Wu, X., Hülse, J., Pedersen, E., Helin, K., Waisman, A., Vinkel, C., Thomsen, S. F., Avgustinova, A., Benitah, S. A., Lovato, P., Norsgaard, H., Mortensen, M. S., Veng, L., Rozell, B., & Brakebusch, C. (2018). Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nature Communications, 9(1), 1-18. [1420]. https://doi.org/10.1038/s41467-018-03704-z

Vancouver

Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E o.a. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nature Communications. 2018;9(1):1-18. 1420. https://doi.org/10.1038/s41467-018-03704-z

Author

Li, Hui ; Yao, Qi ; Mariscal, Alberto Garcia ; Wu, Xudong ; Hülse, Justus ; Pedersen, Esben ; Helin, Kristian ; Waisman, Ari ; Vinkel, Caroline ; Thomsen, Simon Francis ; Avgustinova, Alexandra ; Benitah, Salvador Aznar ; Lovato, Paola ; Norsgaard, Hanne ; Mortensen, Mette Sidsel ; Veng, Lone ; Rozell, Björn ; Brakebusch, Cord. / Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. I: Nature Communications. 2018 ; Bind 9, Nr. 1. s. 1-18.

Bibtex

@article{0d380a760feb449582688c8ba5e9cddd,
title = "Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation",
abstract = "The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation.",
author = "Hui Li and Qi Yao and Mariscal, {Alberto Garcia} and Xudong Wu and Justus H{\"u}lse and Esben Pedersen and Kristian Helin and Ari Waisman and Caroline Vinkel and Thomsen, {Simon Francis} and Alexandra Avgustinova and Benitah, {Salvador Aznar} and Paola Lovato and Hanne Norsgaard and Mortensen, {Mette Sidsel} and Lone Veng and Bj{\"o}rn Rozell and Cord Brakebusch",
year = "2018",
doi = "10.1038/s41467-018-03704-z",
language = "English",
volume = "9",
pages = "1--18",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

AU - Li, Hui

AU - Yao, Qi

AU - Mariscal, Alberto Garcia

AU - Wu, Xudong

AU - Hülse, Justus

AU - Pedersen, Esben

AU - Helin, Kristian

AU - Waisman, Ari

AU - Vinkel, Caroline

AU - Thomsen, Simon Francis

AU - Avgustinova, Alexandra

AU - Benitah, Salvador Aznar

AU - Lovato, Paola

AU - Norsgaard, Hanne

AU - Mortensen, Mette Sidsel

AU - Veng, Lone

AU - Rozell, Björn

AU - Brakebusch, Cord

PY - 2018

Y1 - 2018

N2 - The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation.

AB - The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation.

U2 - 10.1038/s41467-018-03704-z

DO - 10.1038/s41467-018-03704-z

M3 - Journal article

C2 - 29650963

AN - SCOPUS:85045508146

VL - 9

SP - 1

EP - 18

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1420

ER -

ID: 199320903