Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

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Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. / Sun, Kai; Park, Jiyoung; Gupta, Olga T; Holland, William L; Auerbach, Pernille; Zhang, Ningyan; Goncalves Marangoni, Roberta; Nicoloro, Sarah M; Czech, Michael P; Varga, John; Ploug, Thorkil; An, Zhiqiang; Scherer, Philipp E.

I: Nature Communications, Bind 5, 3485, 03.2014.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

Harvard

Sun, K, Park, J, Gupta, OT, Holland, WL, Auerbach, P, Zhang, N, Goncalves Marangoni, R, Nicoloro, SM, Czech, MP, Varga, J, Ploug, T, An, Z & Scherer, PE 2014, 'Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction', Nature Communications, bind 5, 3485. https://doi.org/10.1038/ncomms4485

APA

Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., Ploug, T., An, Z., & Scherer, P. E. (2014). Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nature Communications, 5, [3485]. https://doi.org/10.1038/ncomms4485

Vancouver

Sun K, Park J, Gupta OT, Holland WL, Auerbach P, Zhang N o.a. Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nature Communications. 2014 mar.;5. 3485. https://doi.org/10.1038/ncomms4485

Author

Sun, Kai ; Park, Jiyoung ; Gupta, Olga T ; Holland, William L ; Auerbach, Pernille ; Zhang, Ningyan ; Goncalves Marangoni, Roberta ; Nicoloro, Sarah M ; Czech, Michael P ; Varga, John ; Ploug, Thorkil ; An, Zhiqiang ; Scherer, Philipp E. / Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. I: Nature Communications. 2014 ; Bind 5.

Bibtex

@article{71ffc870b1d1400da30b7231fa4df1a8,
title = "Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction",
abstract = "We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific endotrophin overexpression model to demonstrate that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD). Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy' adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to enhanced insulin resistance. We further demonstrate that blocking endotrophin with a neutralizing antibody ameliorates metabolically adverse effects and effectively reverses metabolic dysfunction induced during HFD exposure. Collectively, our findings demonstrate that endotrophin exerts a major influence in adipose tissue, eventually resulting in systemic elevation of pro-inflammatory cytokines and insulin resistance, and the results establish endotrophin as a potential target in the context of metabolism and cancer.",
author = "Kai Sun and Jiyoung Park and Gupta, {Olga T} and Holland, {William L} and Pernille Auerbach and Ningyan Zhang and {Goncalves Marangoni}, Roberta and Nicoloro, {Sarah M} and Czech, {Michael P} and John Varga and Thorkil Ploug and Zhiqiang An and Scherer, {Philipp E}",
year = "2014",
month = mar,
doi = "10.1038/ncomms4485",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

AU - Sun, Kai

AU - Park, Jiyoung

AU - Gupta, Olga T

AU - Holland, William L

AU - Auerbach, Pernille

AU - Zhang, Ningyan

AU - Goncalves Marangoni, Roberta

AU - Nicoloro, Sarah M

AU - Czech, Michael P

AU - Varga, John

AU - Ploug, Thorkil

AU - An, Zhiqiang

AU - Scherer, Philipp E

PY - 2014/3

Y1 - 2014/3

N2 - We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific endotrophin overexpression model to demonstrate that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD). Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy' adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to enhanced insulin resistance. We further demonstrate that blocking endotrophin with a neutralizing antibody ameliorates metabolically adverse effects and effectively reverses metabolic dysfunction induced during HFD exposure. Collectively, our findings demonstrate that endotrophin exerts a major influence in adipose tissue, eventually resulting in systemic elevation of pro-inflammatory cytokines and insulin resistance, and the results establish endotrophin as a potential target in the context of metabolism and cancer.

AB - We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific endotrophin overexpression model to demonstrate that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD). Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy' adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to enhanced insulin resistance. We further demonstrate that blocking endotrophin with a neutralizing antibody ameliorates metabolically adverse effects and effectively reverses metabolic dysfunction induced during HFD exposure. Collectively, our findings demonstrate that endotrophin exerts a major influence in adipose tissue, eventually resulting in systemic elevation of pro-inflammatory cytokines and insulin resistance, and the results establish endotrophin as a potential target in the context of metabolism and cancer.

U2 - 10.1038/ncomms4485

DO - 10.1038/ncomms4485

M3 - Journal article

C2 - 24647224

VL - 5

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 3485

ER -

ID: 113981355