Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

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Standard

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction : a Randomized Placebo Controlled Trial. / Ekeloef, Sarah; Halladin, Natalie; Fonnes, Siv; Jensen, Svend Eggert; Zaremba, Tomas; Rosenberg, Jacob; Jonsson, Grete; Aarøe, Jens; Gasbjerg, Lærke Smidt; Rosenkilde, Mette Marie; Gögenur, Ismail.

I: Journal of Cardiovascular Translational Research, Bind 10, Nr. 5-6, 12.2017, s. 470-479.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ekeloef, S, Halladin, N, Fonnes, S, Jensen, SE, Zaremba, T, Rosenberg, J, Jonsson, G, Aarøe, J, Gasbjerg, LS, Rosenkilde, MM & Gögenur, I 2017, 'Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial', Journal of Cardiovascular Translational Research, bind 10, nr. 5-6, s. 470-479. https://doi.org/10.1007/s12265-017-9768-7

APA

Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, J., Jonsson, G., Aarøe, J., Gasbjerg, L. S., Rosenkilde, M. M., & Gögenur, I. (2017). Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. Journal of Cardiovascular Translational Research, 10(5-6), 470-479. https://doi.org/10.1007/s12265-017-9768-7

Vancouver

Ekeloef S, Halladin N, Fonnes S, Jensen SE, Zaremba T, Rosenberg J o.a. Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. Journal of Cardiovascular Translational Research. 2017 dec.;10(5-6):470-479. https://doi.org/10.1007/s12265-017-9768-7

Author

Ekeloef, Sarah ; Halladin, Natalie ; Fonnes, Siv ; Jensen, Svend Eggert ; Zaremba, Tomas ; Rosenberg, Jacob ; Jonsson, Grete ; Aarøe, Jens ; Gasbjerg, Lærke Smidt ; Rosenkilde, Mette Marie ; Gögenur, Ismail. / Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction : a Randomized Placebo Controlled Trial. I: Journal of Cardiovascular Translational Research. 2017 ; Bind 10, Nr. 5-6. s. 470-479.

Bibtex

@article{ce11955b254b4b9b9c08159625e0d0a1,
title = "Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial",
abstract = "Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.",
keywords = "Acute myocardial infarction, Ischemic heart disease, Melatonin, Myocardial reperfusion injury, Primary percutaneous coronary intervention",
author = "Sarah Ekeloef and Natalie Halladin and Siv Fonnes and Jensen, {Svend Eggert} and Tomas Zaremba and Jacob Rosenberg and Grete Jonsson and Jens Aar{\o}e and Gasbjerg, {L{\ae}rke Smidt} and Rosenkilde, {Mette Marie} and Ismail G{\"o}genur",
year = "2017",
month = dec,
doi = "10.1007/s12265-017-9768-7",
language = "English",
volume = "10",
pages = "470--479",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer",
number = "5-6",

}

RIS

TY - JOUR

T1 - Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction

T2 - a Randomized Placebo Controlled Trial

AU - Ekeloef, Sarah

AU - Halladin, Natalie

AU - Fonnes, Siv

AU - Jensen, Svend Eggert

AU - Zaremba, Tomas

AU - Rosenberg, Jacob

AU - Jonsson, Grete

AU - Aarøe, Jens

AU - Gasbjerg, Lærke Smidt

AU - Rosenkilde, Mette Marie

AU - Gögenur, Ismail

PY - 2017/12

Y1 - 2017/12

N2 - Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

AB - Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

KW - Acute myocardial infarction

KW - Ischemic heart disease

KW - Melatonin

KW - Myocardial reperfusion injury

KW - Primary percutaneous coronary intervention

U2 - 10.1007/s12265-017-9768-7

DO - 10.1007/s12265-017-9768-7

M3 - Journal article

C2 - 29027116

AN - SCOPUS:85031415342

VL - 10

SP - 470

EP - 479

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 5-6

ER -

ID: 187624994