Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure

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Standard

Effect of glucagon-like peptide-2 exposure on bone resorption : Effectiveness of high concentration versus prolonged exposure. / Askov-Hansen, Carsten; Jeppesen, Palle B; Lund, Pernille; Hartmann, Bolette; Holst, Jens Juul; Henriksen, Dennis B.

I: Regulatory Peptides, Bind 181, 10.02.2013, s. 4-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Askov-Hansen, C, Jeppesen, PB, Lund, P, Hartmann, B, Holst, JJ & Henriksen, DB 2013, 'Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure', Regulatory Peptides, bind 181, s. 4-8. https://doi.org/10.1016/j.regpep.2012.11.002

APA

Askov-Hansen, C., Jeppesen, P. B., Lund, P., Hartmann, B., Holst, J. J., & Henriksen, D. B. (2013). Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure. Regulatory Peptides, 181, 4-8. https://doi.org/10.1016/j.regpep.2012.11.002

Vancouver

Askov-Hansen C, Jeppesen PB, Lund P, Hartmann B, Holst JJ, Henriksen DB. Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure. Regulatory Peptides. 2013 feb 10;181:4-8. https://doi.org/10.1016/j.regpep.2012.11.002

Author

Askov-Hansen, Carsten ; Jeppesen, Palle B ; Lund, Pernille ; Hartmann, Bolette ; Holst, Jens Juul ; Henriksen, Dennis B. / Effect of glucagon-like peptide-2 exposure on bone resorption : Effectiveness of high concentration versus prolonged exposure. I: Regulatory Peptides. 2013 ; Bind 181. s. 4-8.

Bibtex

@article{fdd0ee6a95c2484498f6a9232e0d3533,
title = "Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure",
abstract = "In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.",
author = "Carsten Askov-Hansen and Jeppesen, {Palle B} and Pernille Lund and Bolette Hartmann and Holst, {Jens Juul} and Henriksen, {Dennis B}",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2013",
month = "2",
day = "10",
doi = "10.1016/j.regpep.2012.11.002",
language = "English",
volume = "181",
pages = "4--8",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of glucagon-like peptide-2 exposure on bone resorption

T2 - Effectiveness of high concentration versus prolonged exposure

AU - Askov-Hansen, Carsten

AU - Jeppesen, Palle B

AU - Lund, Pernille

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Henriksen, Dennis B

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2013/2/10

Y1 - 2013/2/10

N2 - In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.

AB - In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.

U2 - 10.1016/j.regpep.2012.11.002

DO - 10.1016/j.regpep.2012.11.002

M3 - Journal article

C2 - 23261963

VL - 181

SP - 4

EP - 8

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

ER -

ID: 45840378