Dried urine swabs as a tool for monitoring metabolite excretion

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Standard

Dried urine swabs as a tool for monitoring metabolite excretion. / Monošík, Rastislav; Dragsted, Lars Ove.

I: Bioanalysis, Bind 10, Nr. 17, 2018, s. 1371-1382.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Monošík, R & Dragsted, LO 2018, 'Dried urine swabs as a tool for monitoring metabolite excretion', Bioanalysis, bind 10, nr. 17, s. 1371-1382. https://doi.org/10.4155/bio-2018-0042

APA

Monošík, R., & Dragsted, L. O. (2018). Dried urine swabs as a tool for monitoring metabolite excretion. Bioanalysis, 10(17), 1371-1382. https://doi.org/10.4155/bio-2018-0042

Vancouver

Monošík R, Dragsted LO. Dried urine swabs as a tool for monitoring metabolite excretion. Bioanalysis. 2018;10(17):1371-1382. https://doi.org/10.4155/bio-2018-0042

Author

Monošík, Rastislav ; Dragsted, Lars Ove. / Dried urine swabs as a tool for monitoring metabolite excretion. I: Bioanalysis. 2018 ; Bind 10, Nr. 17. s. 1371-1382.

Bibtex

@article{7633a7331be44600aebf4de7983135fa,
title = "Dried urine swabs as a tool for monitoring metabolite excretion",
abstract = "Aim: We tested a large set (n = 181) of wet urine and dried urine samples spotted on regular cosmetic cotton swabs for comparative UHPLC-MSMS analysis of various metabolites across a wide polarity and structural range. Results/methodology: The agreement of measurements between conventional 24 h urines and dried urine spots made from them in situ was evaluated by Passing-Bablok regression and Bland-Altman analysis after creatinine correction. There was full agreement in qualitative results but quantitative analysis revealed underestimation of dried urine spots in some cases. The dried urine samples contained analytes at measurable levels for at least 9 months.Conclusion: Although this technique seems very promising more methodological studies have to be conducted in order to improve applicability of dried urine microvolume fluidic sampling for quantitative analysis.",
keywords = "Faculty of Science, UHPLC-MS/MS, Creatinine correction, Dried urine spots",
author = "Rastislav Mono{\v s}{\'i}k and Dragsted, {Lars Ove}",
note = "CURIS 2018 NEXS 274",
year = "2018",
doi = "10.4155/bio-2018-0042",
language = "English",
volume = "10",
pages = "1371--1382",
journal = "Bioanalysis",
issn = "1757-6180",
publisher = "Future Science",
number = "17",

}

RIS

TY - JOUR

T1 - Dried urine swabs as a tool for monitoring metabolite excretion

AU - Monošík, Rastislav

AU - Dragsted, Lars Ove

N1 - CURIS 2018 NEXS 274

PY - 2018

Y1 - 2018

N2 - Aim: We tested a large set (n = 181) of wet urine and dried urine samples spotted on regular cosmetic cotton swabs for comparative UHPLC-MSMS analysis of various metabolites across a wide polarity and structural range. Results/methodology: The agreement of measurements between conventional 24 h urines and dried urine spots made from them in situ was evaluated by Passing-Bablok regression and Bland-Altman analysis after creatinine correction. There was full agreement in qualitative results but quantitative analysis revealed underestimation of dried urine spots in some cases. The dried urine samples contained analytes at measurable levels for at least 9 months.Conclusion: Although this technique seems very promising more methodological studies have to be conducted in order to improve applicability of dried urine microvolume fluidic sampling for quantitative analysis.

AB - Aim: We tested a large set (n = 181) of wet urine and dried urine samples spotted on regular cosmetic cotton swabs for comparative UHPLC-MSMS analysis of various metabolites across a wide polarity and structural range. Results/methodology: The agreement of measurements between conventional 24 h urines and dried urine spots made from them in situ was evaluated by Passing-Bablok regression and Bland-Altman analysis after creatinine correction. There was full agreement in qualitative results but quantitative analysis revealed underestimation of dried urine spots in some cases. The dried urine samples contained analytes at measurable levels for at least 9 months.Conclusion: Although this technique seems very promising more methodological studies have to be conducted in order to improve applicability of dried urine microvolume fluidic sampling for quantitative analysis.

KW - Faculty of Science

KW - UHPLC-MS/MS

KW - Creatinine correction

KW - Dried urine spots

U2 - 10.4155/bio-2018-0042

DO - 10.4155/bio-2018-0042

M3 - Journal article

C2 - 30088416

VL - 10

SP - 1371

EP - 1382

JO - Bioanalysis

JF - Bioanalysis

SN - 1757-6180

IS - 17

ER -

ID: 201043993