Does epidermal growth factor play a role in the action of sucralfate?

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Standard

Does epidermal growth factor play a role in the action of sucralfate? / Nexø, Ebba; Poulsen, Steen Seier.

I: Scandinavian Journal of Gastroenterology. Supplement, Bind 127, 1987, s. 45-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nexø, E & Poulsen, SS 1987, 'Does epidermal growth factor play a role in the action of sucralfate?', Scandinavian Journal of Gastroenterology. Supplement, bind 127, s. 45-9.

APA

Nexø, E., & Poulsen, S. S. (1987). Does epidermal growth factor play a role in the action of sucralfate? Scandinavian Journal of Gastroenterology. Supplement, 127, 45-9.

Vancouver

Nexø E, Poulsen SS. Does epidermal growth factor play a role in the action of sucralfate? Scandinavian Journal of Gastroenterology. Supplement. 1987;127:45-9.

Author

Nexø, Ebba ; Poulsen, Steen Seier. / Does epidermal growth factor play a role in the action of sucralfate?. I: Scandinavian Journal of Gastroenterology. Supplement. 1987 ; Bind 127. s. 45-9.

Bibtex

@article{751f4ac3c385415da0259f979a0481d3,
title = "Does epidermal growth factor play a role in the action of sucralfate?",
abstract = "Epidermal growth factor (EGF) is a mitogenic peptide synthesized in the submandibular glands and released in saliva. EGF is able to prevent the development of gastrointestinal ulcers in the rat and to accelerate their healing. The present work was undertaken to examine whether Sucralfate acts via the effector system of EGF. We conclude that Sucralfate does not change the binding of EGF to its receptor, but it is able to bind EGF in a pH dependent manner and at pH below 4.5 virtually all EGF is bound to Sucralfate. In vivo studies in rats with acid-induced gastric ulcers show that sucralfate carries EGF to the ulcer, and that EGF is available for a longer period of time (3 hours) when EGF and Sucralfate are is given together than when EGF is given alone.",
keywords = "Animals, Epidermal Growth Factor, Humans, Male, Mice, Rats, Rats, Inbred Strains, Receptor, Epidermal Growth Factor, Stomach Ulcer, Sucralfate",
author = "Ebba Nex{\o} and Poulsen, {Steen Seier}",
year = "1987",
language = "English",
volume = "127",
pages = "45--9",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - Does epidermal growth factor play a role in the action of sucralfate?

AU - Nexø, Ebba

AU - Poulsen, Steen Seier

PY - 1987

Y1 - 1987

N2 - Epidermal growth factor (EGF) is a mitogenic peptide synthesized in the submandibular glands and released in saliva. EGF is able to prevent the development of gastrointestinal ulcers in the rat and to accelerate their healing. The present work was undertaken to examine whether Sucralfate acts via the effector system of EGF. We conclude that Sucralfate does not change the binding of EGF to its receptor, but it is able to bind EGF in a pH dependent manner and at pH below 4.5 virtually all EGF is bound to Sucralfate. In vivo studies in rats with acid-induced gastric ulcers show that sucralfate carries EGF to the ulcer, and that EGF is available for a longer period of time (3 hours) when EGF and Sucralfate are is given together than when EGF is given alone.

AB - Epidermal growth factor (EGF) is a mitogenic peptide synthesized in the submandibular glands and released in saliva. EGF is able to prevent the development of gastrointestinal ulcers in the rat and to accelerate their healing. The present work was undertaken to examine whether Sucralfate acts via the effector system of EGF. We conclude that Sucralfate does not change the binding of EGF to its receptor, but it is able to bind EGF in a pH dependent manner and at pH below 4.5 virtually all EGF is bound to Sucralfate. In vivo studies in rats with acid-induced gastric ulcers show that sucralfate carries EGF to the ulcer, and that EGF is available for a longer period of time (3 hours) when EGF and Sucralfate are is given together than when EGF is given alone.

KW - Animals

KW - Epidermal Growth Factor

KW - Humans

KW - Male

KW - Mice

KW - Rats

KW - Rats, Inbred Strains

KW - Receptor, Epidermal Growth Factor

KW - Stomach Ulcer

KW - Sucralfate

M3 - Journal article

C2 - 3497432

VL - 127

SP - 45

EP - 49

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

ER -

ID: 47488731