Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study

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Differential time responses in inflammatory and oxidative stress markers after a marathon : An observational study. / Larsen, Emil List; Poulsen, Henrik Enghusen; Michaelsen, Cristina; Kjær, Laura Kofoed; Lyngbæk, Mark; Andersen, Emilie Skytte; Petersen-Bønding, Christina; Lemoine, Clara; Gillum, Matthew; Jørgensen, Niklas Rye; Ploug, Thorkil; Vilsbøll, Tina; Knop, Filip Krag; Karstoft, Kristian.

I: Journal of Sports Sciences, Bind 38, Nr. 18, 2020, s. 2080-2091.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Larsen, EL, Poulsen, HE, Michaelsen, C, Kjær, LK, Lyngbæk, M, Andersen, ES, Petersen-Bønding, C, Lemoine, C, Gillum, M, Jørgensen, NR, Ploug, T, Vilsbøll, T, Knop, FK & Karstoft, K 2020, 'Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study', Journal of Sports Sciences, bind 38, nr. 18, s. 2080-2091. https://doi.org/10.1080/02640414.2020.1770918

APA

Larsen, E. L., Poulsen, H. E., Michaelsen, C., Kjær, L. K., Lyngbæk, M., Andersen, E. S., Petersen-Bønding, C., Lemoine, C., Gillum, M., Jørgensen, N. R., Ploug, T., Vilsbøll, T., Knop, F. K., & Karstoft, K. (2020). Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study. Journal of Sports Sciences, 38(18), 2080-2091. https://doi.org/10.1080/02640414.2020.1770918

Vancouver

Larsen EL, Poulsen HE, Michaelsen C, Kjær LK, Lyngbæk M, Andersen ES o.a. Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study. Journal of Sports Sciences. 2020;38(18):2080-2091. https://doi.org/10.1080/02640414.2020.1770918

Author

Larsen, Emil List ; Poulsen, Henrik Enghusen ; Michaelsen, Cristina ; Kjær, Laura Kofoed ; Lyngbæk, Mark ; Andersen, Emilie Skytte ; Petersen-Bønding, Christina ; Lemoine, Clara ; Gillum, Matthew ; Jørgensen, Niklas Rye ; Ploug, Thorkil ; Vilsbøll, Tina ; Knop, Filip Krag ; Karstoft, Kristian. / Differential time responses in inflammatory and oxidative stress markers after a marathon : An observational study. I: Journal of Sports Sciences. 2020 ; Bind 38, Nr. 18. s. 2080-2091.

Bibtex

@article{b259afc8375b48278487d5a52130d68c,
title = "Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study",
abstract = "Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.",
keywords = "Bone metabolism, exercise, fibroblast growth factor 21, inflammation, oxidative stress",
author = "Larsen, {Emil List} and Poulsen, {Henrik Enghusen} and Cristina Michaelsen and Kj{\ae}r, {Laura Kofoed} and Mark Lyngb{\ae}k and Andersen, {Emilie Skytte} and Christina Petersen-B{\o}nding and Clara Lemoine and Matthew Gillum and J{\o}rgensen, {Niklas Rye} and Thorkil Ploug and Tina Vilsb{\o}ll and Knop, {Filip Krag} and Kristian Karstoft",
year = "2020",
doi = "10.1080/02640414.2020.1770918",
language = "English",
volume = "38",
pages = "2080--2091",
journal = "Journal of Sports Sciences",
issn = "0264-0414",
publisher = "Routledge",
number = "18",

}

RIS

TY - JOUR

T1 - Differential time responses in inflammatory and oxidative stress markers after a marathon

T2 - An observational study

AU - Larsen, Emil List

AU - Poulsen, Henrik Enghusen

AU - Michaelsen, Cristina

AU - Kjær, Laura Kofoed

AU - Lyngbæk, Mark

AU - Andersen, Emilie Skytte

AU - Petersen-Bønding, Christina

AU - Lemoine, Clara

AU - Gillum, Matthew

AU - Jørgensen, Niklas Rye

AU - Ploug, Thorkil

AU - Vilsbøll, Tina

AU - Knop, Filip Krag

AU - Karstoft, Kristian

PY - 2020

Y1 - 2020

N2 - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.

AB - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.

KW - Bone metabolism

KW - exercise

KW - fibroblast growth factor 21

KW - inflammation

KW - oxidative stress

U2 - 10.1080/02640414.2020.1770918

DO - 10.1080/02640414.2020.1770918

M3 - Journal article

C2 - 32530734

AN - SCOPUS:85087130837

VL - 38

SP - 2080

EP - 2091

JO - Journal of Sports Sciences

JF - Journal of Sports Sciences

SN - 0264-0414

IS - 18

ER -

ID: 246869454