Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study

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Differential time responses in inflammatory and oxidative stress markers after a marathon : An observational study. / Larsen, Emil List; Poulsen, Henrik Enghusen; Michaelsen, Cristina; Kjær, Laura Kofoed; Lyngbæk, Mark; Andersen, Emilie Skytte; Petersen-Bønding, Christina; Lemoine, Clara; Gillum, Matthew; Jørgensen, Niklas Rye; Ploug, Thorkil; Vilsbøll, Tina; Knop, Filip Krag; Karstoft, Kristian.

I: Journal of Sports Sciences, Bind 38, Nr. 18, 2020, s. 2080-2091.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Larsen, EL, Poulsen, HE, Michaelsen, C, Kjær, LK, Lyngbæk, M, Andersen, ES, Petersen-Bønding, C, Lemoine, C, Gillum, M, Jørgensen, NR, Ploug, T, Vilsbøll, T, Knop, FK & Karstoft, K 2020, 'Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study', Journal of Sports Sciences, bind 38, nr. 18, s. 2080-2091. https://doi.org/10.1080/02640414.2020.1770918

APA

Larsen, E. L., Poulsen, H. E., Michaelsen, C., Kjær, L. K., Lyngbæk, M., Andersen, E. S., ... Karstoft, K. (2020). Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study. Journal of Sports Sciences, 38(18), 2080-2091. https://doi.org/10.1080/02640414.2020.1770918

Vancouver

Larsen EL, Poulsen HE, Michaelsen C, Kjær LK, Lyngbæk M, Andersen ES o.a. Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study. Journal of Sports Sciences. 2020;38(18):2080-2091. https://doi.org/10.1080/02640414.2020.1770918

Author

Larsen, Emil List ; Poulsen, Henrik Enghusen ; Michaelsen, Cristina ; Kjær, Laura Kofoed ; Lyngbæk, Mark ; Andersen, Emilie Skytte ; Petersen-Bønding, Christina ; Lemoine, Clara ; Gillum, Matthew ; Jørgensen, Niklas Rye ; Ploug, Thorkil ; Vilsbøll, Tina ; Knop, Filip Krag ; Karstoft, Kristian. / Differential time responses in inflammatory and oxidative stress markers after a marathon : An observational study. I: Journal of Sports Sciences. 2020 ; Bind 38, Nr. 18. s. 2080-2091.

Bibtex

@article{b259afc8375b48278487d5a52130d68c,
title = "Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study",
abstract = "Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95{\%} CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95{\%} CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95{\%}CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.",
keywords = "Bone metabolism, exercise, fibroblast growth factor 21, inflammation, oxidative stress",
author = "Larsen, {Emil List} and Poulsen, {Henrik Enghusen} and Cristina Michaelsen and Kj{\ae}r, {Laura Kofoed} and Mark Lyngb{\ae}k and Andersen, {Emilie Skytte} and Christina Petersen-B{\o}nding and Clara Lemoine and Matthew Gillum and J{\o}rgensen, {Niklas Rye} and Thorkil Ploug and Tina Vilsb{\o}ll and Knop, {Filip Krag} and Kristian Karstoft",
year = "2020",
doi = "10.1080/02640414.2020.1770918",
language = "English",
volume = "38",
pages = "2080--2091",
journal = "Journal of Sports Sciences",
issn = "0264-0414",
publisher = "Routledge",
number = "18",

}

RIS

TY - JOUR

T1 - Differential time responses in inflammatory and oxidative stress markers after a marathon

T2 - An observational study

AU - Larsen, Emil List

AU - Poulsen, Henrik Enghusen

AU - Michaelsen, Cristina

AU - Kjær, Laura Kofoed

AU - Lyngbæk, Mark

AU - Andersen, Emilie Skytte

AU - Petersen-Bønding, Christina

AU - Lemoine, Clara

AU - Gillum, Matthew

AU - Jørgensen, Niklas Rye

AU - Ploug, Thorkil

AU - Vilsbøll, Tina

AU - Knop, Filip Krag

AU - Karstoft, Kristian

PY - 2020

Y1 - 2020

N2 - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.

AB - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.

KW - Bone metabolism

KW - exercise

KW - fibroblast growth factor 21

KW - inflammation

KW - oxidative stress

U2 - 10.1080/02640414.2020.1770918

DO - 10.1080/02640414.2020.1770918

M3 - Journal article

C2 - 32530734

AN - SCOPUS:85087130837

VL - 38

SP - 2080

EP - 2091

JO - Journal of Sports Sciences

JF - Journal of Sports Sciences

SN - 0264-0414

IS - 18

ER -

ID: 246869454