Copeptin in anorexia nervosa

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Standard

Copeptin in anorexia nervosa. / Goetze, Jens P.; Støving, René Klinkby.

I: Brain and Behavior, Bind 10, Nr. 4, e01551, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Goetze, JP & Støving, RK 2020, 'Copeptin in anorexia nervosa', Brain and Behavior, bind 10, nr. 4, e01551. https://doi.org/10.1002/brb3.1551

APA

Goetze, J. P., & Støving, R. K. (2020). Copeptin in anorexia nervosa. Brain and Behavior, 10(4), [e01551]. https://doi.org/10.1002/brb3.1551

Vancouver

Goetze JP, Støving RK. Copeptin in anorexia nervosa. Brain and Behavior. 2020;10(4). e01551. https://doi.org/10.1002/brb3.1551

Author

Goetze, Jens P. ; Støving, René Klinkby. / Copeptin in anorexia nervosa. I: Brain and Behavior. 2020 ; Bind 10, Nr. 4.

Bibtex

@article{a25e0db6f41746e3b4f11becaf9505b8,
title = "Copeptin in anorexia nervosa",
abstract = "Objective: Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half-life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C-terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods: We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age-matched women. Results: No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion: We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid- and electrolyte-stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN.",
keywords = "anorexia nervosa, antidiuretic hormone, arginine vasopressin, copeptin, insulin",
author = "Goetze, {Jens P.} and St{\o}ving, {Ren{\'e} Klinkby}",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.",
year = "2020",
doi = "10.1002/brb3.1551",
language = "English",
volume = "10",
journal = "Brain and Behavior",
issn = "2162-3279",
publisher = "JohnWiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Copeptin in anorexia nervosa

AU - Goetze, Jens P.

AU - Støving, René Klinkby

N1 - Publisher Copyright: © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

PY - 2020

Y1 - 2020

N2 - Objective: Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half-life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C-terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods: We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age-matched women. Results: No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion: We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid- and electrolyte-stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN.

AB - Objective: Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half-life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C-terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods: We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age-matched women. Results: No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion: We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid- and electrolyte-stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN.

KW - anorexia nervosa

KW - antidiuretic hormone

KW - arginine vasopressin

KW - copeptin

KW - insulin

UR - http://www.scopus.com/inward/record.url?scp=85079880018&partnerID=8YFLogxK

U2 - 10.1002/brb3.1551

DO - 10.1002/brb3.1551

M3 - Journal article

C2 - 32073757

AN - SCOPUS:85079880018

VL - 10

JO - Brain and Behavior

JF - Brain and Behavior

SN - 2162-3279

IS - 4

M1 - e01551

ER -

ID: 270209942