TY - JOUR

T1 - Contribution of skeletal muscle and adipose tissue to adrenaline-induced thermogenesis in man

AU - Simonsen, L

AU - Stallknecht, B

AU - Bülow, J

N1 - Keywords: Adipose Tissue; Adult; Blood Flow Velocity; Body Temperature Regulation; Energy Metabolism; Epinephrine; Female; Glucose; Humans; Kinetics; Lactates; Lactic Acid; Male; Muscles; Oxygen Consumption

PY - 1993

Y1 - 1993

N2 - Elevated plasma adrenaline is known to increase whole body energy expenditure. We studied the thermogenic effect and the effects on substrate utilization in man during infusion of adrenaline. Two series were performed: in one series skeletal muscle metabolism was investigated and in another series subcutaneous adipose tissue metabolism was investigated. In both series Fick's principle was applied. Intravenous infusion increased blood flow, glucose uptake and oxygen uptake in both skeletal muscle and adipose tissue. It is concluded that skeletal muscle contributes about 40% and adipose tissue about 5% of the whole body adrenaline-induced thermogenesis.

AB - Elevated plasma adrenaline is known to increase whole body energy expenditure. We studied the thermogenic effect and the effects on substrate utilization in man during infusion of adrenaline. Two series were performed: in one series skeletal muscle metabolism was investigated and in another series subcutaneous adipose tissue metabolism was investigated. In both series Fick's principle was applied. Intravenous infusion increased blood flow, glucose uptake and oxygen uptake in both skeletal muscle and adipose tissue. It is concluded that skeletal muscle contributes about 40% and adipose tissue about 5% of the whole body adrenaline-induced thermogenesis.

M3 - Review

C2 - 8124401

VL - 17 Suppl 3

SP - S47-51; discussion S68

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -